Navigation Links
Imaging Shows Long-term Impact of Blast-induced Brain Injuries in Veterans
Date:12/1/2013

CHICAGO, Dec. 2, 2013 /PRNewswire-USNewswire/ -- Using a special type of magnetic resonance imaging (MRI), researchers have found that soldiers who suffered mild traumatic brain injury (MTBI) induced by blast exposure exhibit long-term brain differences, according to a study being presented today at the annual meeting of the Radiological Society of North America (RSNA).

Recent wars have resulted in veterans with an exposure rate of approximately 20 percent to blast-induced MTBI, or trauma resulting from mortar fire and improvised explosive devices. Diagnosis can be challenging, especially in mild cases.

"Mild traumatic brain injury is difficult to identify using standard CT or MRI," said study co-author P. Tyler Roskos, Ph.D., a neuropsychologist and assistant research professor at the Saint Louis University School of Medicine in St. Louis, Mo. "Other methods may have added sensitivity."

One of those methods is diffusion tensor imaging (DTI), an MRI technique used to identify microstructural injury to white matter, the part of the brain that consists mostly of signal-carrying axons. Damage-associated changes in water movement along the axons are comparable in certain respects to what might happen with a garden hose, according to co-author Thomas M. Malone, B.A., research associate at Saint Louis University School of Medicine.

"As water passes through the hose from the faucet to the sprinkler, it goes in the same direction, but if you were to puncture the hose with a rake, the water would shoot out the sides," Malone said.

In the study, researchers compared DTI-derived fractional anisotropy (FA) values in 10 veterans of Operations Iraqi Freedom and Enduring Freedom who had been diagnosed with MTBI with those of 10 healthy controls. FA measures the uniformity of water diffusion throughout the brain, and low FA tends to indicate areas of axonal injury. The average time elapsed between the blast-induced injury and DTI among the patients was 51.3 months.

"The time since injury is a novel component to our study," Dr. Roskos said. "Most other blast-related MTBI studies examine patients in the acute phase of injury."

Comparison of FA values showed significant differences between the two groups, and there were significant correlations between FA values and attention, delayed memory and psychomotor test scores. Since the victims were, on average, more than four years removed from their injuries, the results suggest the presence of a long-term impact of blast injury on the brain.

"This long-term impact on the brain may account for ongoing cognitive and behavioral symptoms in some veterans with a history of blast-related MTBI," Dr. Roskos said.

The results also indicate that DTI is sensitive to group differences in blast-related MTBI even in the post-acute phase.

"DTI shows promise in enhanced sensitivity for detecting MTBI compared to MRI/CT, even in the chronic phase," Dr. Roskos said. "Identification of changes in specific brain regions may help in diagnosis and treatment of MTBI among veterans."

Dr. Roskos explained that this research is aimed at finding better ways for the clinician to differentiate between MTBI and PTSD in veterans in order to improve treatment.

"It makes a difference, because PTSD is psychological in nature and MTBI is neurological," he said. "Many veterans in the healthcare system are dealing with MTBI, PTSD or both. Our emphasis today is to find the best treatments and measure the patient's progress. Imaging has the potential to do that."

Other co-authors are Jeffrey D. Stout, B.S., Richard R. Bucholz, M.D., Evan Schulze, B.A., Mark Colijn, M.S., and Jacob Bolzenius, M.A.

AT A GLANCE

  • Using diffusion tensor imaging (DTI), research has shown differences in the brains of soldiers who suffered mild traumatic brain injury.
  • The results suggest the presence of a long-term impact of blast injury on the brain.
  • The findings showed correlation between abnormal water diffusion in the brain and problems with memory, attention and motor skills.

Note: Copies of RSNA 2013 news releases and electronic images will be available online at RSNA.org/press13 beginning Monday, Dec. 2.

RSNA is an association of more than 53,000 radiologists, radiation oncologists, medical physicists and related scientists, promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Ill. (RSNA.org)

Editor's note: The data in these releases may differ from those in the published abstract and those actually presented at the meeting, as researchers continue to update their data right up until the meeting. To ensure you are using the most up-to-date information, please call the RSNA Newsroom at 1-312-949-3233.

For patient-friendly information on brain imaging, visit RadiologyInfo.org.


'/>"/>
SOURCE Radiological Society of North America (RSNA)
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Philips unveils breakthrough imaging innovations at RSNA 2013
2. ClearCanvas to Showcase its Imaging Informatics Infrastructure Portfolio at RSNA 2013
3. Elbit Imaging Announces the Results of the Companys Unsecured Financial Creditors Meeting Approving the General Terms of Agreement to be Entered Into With Bank Hapoalim
4. German Experts Present Medical Imaging Advances at RSNA 13
5. Concord Medical Signs MOU with Shanghai New Hongqiao International Medical Center and GE Healthcare to Establish a Medical Imaging Diagnosis Center
6. Frost & Sullivan Applauds EOS Imaging for its Highly Innovative, X-ray-Based Imaging Modality for Orthopedics
7. Seno Medical Instruments Launches Pivotal Study of New Functional Imaging Platform in Breast Cancer Diagnosis
8. New Study by Imaging the World and Philips Demonstrates the Power of Ultrasound Screenings to Transform Maternal and Newborn Care in Rural Uganda
9. Hologic to Showcase its Best-In-Class Imaging Portfolio at RSNA 2013
10. Turkish Diagnostic Imaging System Market Will Fluctuate, While Russian Market Will Grow Moderately Through 2022
11. Philips and RealView Imaging conclude worlds first study to evaluate live 3D holographic imaging in interventional cardiology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... 23, 2016 Capricor Therapeutics, ... a biotechnology company focused on the discovery, development ... patient enrollment in its ongoing randomized HOPE-Duchenne clinical ... 50% of its 24-patient target. Capricor expects the ... quarter of 2016, and to report top line ...
(Date:6/23/2016)... PARK RIDGE, Ill. and INDIANAPOLIS ... caliber of students receiving a Lilly Diabetes Tomorrow,s Leaders ... hands. The 2016 scholarship winners, announced today online at ... refused to let type 1 diabetes stand in the ... Lilly Diabetes has supported the Foundation,s scholarship program since ...
(Date:6/23/2016)... -- The vast majority of dialysis patients currently receive ... usually 3 times a week, with treatment times averaging ... equipment preparation and wait time.  This regimen can be ... who are elderly and frail.  Many elderly dialysis patients ... for some duration of time. Residents in ...
Breaking Medicine Technology:
(Date:6/25/2016)... , ... June 25, 2016 , ... As a lifelong ... Cum Laude and his M.D from the David Geffen School of Medicine at UCLA. ... to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits ... terms of the latter, setting the bar too high can result in disappointment, perhaps ... slow progress toward their goal. , Research from PsychTests.com reveals that ...
(Date:6/24/2016)... ... 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. ... the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has ... , Sickle Cell Disease (SCD) is a disorder of the red blood cells, which ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Global law firm ... 2016 Legal Elite. The attorneys chosen by their peers for this recognition are considered ... Seven Greenberg Traurig Shareholders received special honors as members of this year’s Legal Elite ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway ... call for a minimum wage raise to $12 an hour by 2020 and then adjusting ... restore the lost value of the minimum wage, assure the wage floor does not erode ...
Breaking Medicine News(10 mins):