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Imaging Results From the ADAGIO-LIPIDS Reveal That Effects of Rimonabant on Cardiometabolic Risk Profile Include Loss of Visceral Fat and Mobilization of Liver Fat
Date:4/29/2008

or the first time that rimonabant induced a significant mobilization of liver fat (decrease in the fatty liver index, p<0.005) which was associated with a significant improvement in ALT levels (p<0.001), a commonly used marker of liver function also associated with the features of the metabolic syndrome" he added.

As CB1 receptors are located in organs other than the brain, such as the adipose tissue and the liver, results of ADAGIO-LIPIDS are consistent with the hypothesis that antagonism of the these peripheral CB1 receptors could slow lipogenesis in both adipose tissue and the liver, leading to loss of both visceral and liver fat.

Regarding safety, as patients previously treated for symptoms of depression were excluded from the ADAGIO-LIPIDS trial, the incidence of side effects leading to discontinuation was essentially similar to the previously published phase III studies. "These results provide further evidence of the acceptable safety profile of rimonabant provided that the drug is used as currently recommended in clinical practice. Patients with a history of depression or on anti-depressants should not be treated with rimonabant." emphasized Dr Despres.

"As we now have evidence that patients with visceral obesity represent the subgroup of overweight/obese patients with an activated endocannabinoid system, results of ADAGIO-LIPIDS provide support to the notion that patients with visceral obesity who are often either dyslipidemic or with type 2 diabetes (or both) represent a relevant subpopulation of overweight/obese patients who would particularly benefit from rimonabant therapy" jointly concluded Dr Despres and Ross.

About Hopital Laval

Founded in 1918, Hopital Laval is the heart and lung institute of Universite Laval. It provides the population of Central and Eastern Quebec with subspecialized care and services in cardiology, pneumology, and the surgical management of obesity. The Hospital's expertise includes ambulatory an
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