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Imaging Results From the ADAGIO-LIPIDS Reveal That Effects of Rimonabant on Cardiometabolic Risk Profile Include Loss of Visceral Fat and Mobilization of Liver Fat
Date:4/29/2008

Whereas rimonabant had no effect on LDL-cholesterol levels, the drug induced a major shift in the distribution of the size of LDL particles with a substantial reduction in the proportion of small, atherogenic LDL (decrease of 6.5% vs placebo, p<0.0001) and a concomitant increase in the concentration of large LDL particles (increase of 4.8% vs placebo). Several markers of HDL concentration and quality were also improved with rimonabant compared to placebo including an increase in apo A-I (+3.2% vs placebo, p=0.02), HDL particle size (+0.9% vs placebo, p<0.001) and an increase in levels of both HDL2 (+52.6% vs placebo, p<0.03) and HDL3 (+4.3% vs placebo, p<0.01) subfractions. Apo B was also significantly reduced (-4.4% vs placebo, p<0.01) leading to a decrease in the apo B/apo A-I ratio (p<0.0001). Inflammation was also improved as revealed by a 17% reduction in CRP levels compared to placebo (p<0.01) whereas there was a very significant increase in the blood concentration of an important adipose tissue-derived cytokine, adiponectin, which increased by 18.9% compared to placebo (p<0.0001).

"Results of ADAGIO-LIPIDS are pretty much "textbook" regarding what we knew from endocannabinoid physiology and their effect on lipid metabolism" mentioned Dr Despres. "All markers of cardiometabolic risk improved in the right direction with rimonabant therapy, including a significant reduction of -3.3 mmHg for systolic and of -2.4 mmHg for diastolic blood pressure (p<0.0001). The next important question was, how does rimonabant work?"

"Results of the CT imaging study are pretty straightforward. We found that rimonabant therapy for one year induced a preferential mobilization of visceral adipose tissue compared to placebo (reduction of 10.1% vs placebo, p<0.0005), which was greater that the loss of subcutaneous fat (decrease of 5.1% vs placebo, p<0.005)" stated Dr Robert Ross, the co-principal investigator of ADAGIO-LIPIDS. "Another relevant finding is that we report f
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SOURCE Hopital Laval
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