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Idenix Pharmaceuticals Reports Third Quarter and Nine Month 2011 Financial Results and Provides Pipeline Update
Date:11/2/2011

opment of our NS5A drug candidates.

2011 Financial Guidance
The Company expects that its current cash, cash equivalents and the anticipated royalty payments associated with product sales of Tyzeka®/Sebivo® (telbivudine) will be sufficient to satisfy its cash needs into at least the second quarter of 2012. This guidance assumes no additional milestone payments, license fees, reimbursement for development programs and no financing activities.

Operational HighlightsIDX184 Program
The Company's lead program, IDX184, is a pan-genotypic oral nucleotide polymerase inhibitor that has shown potent antiviral activity in both preclinical and clinical studies. IDX184 is a proprietary liver-targeted prodrug of 2'-methyl guanosine monophosphate with a high barrier to resistance in vitro.

In July 2011, the Company initiated enrollment of 100 HCV-infected patients into a 12-week Phase IIb clinical trial of IDX184 in combination with pegylated interferon and ribavirin. The Company will report an interim analysis from this study after the first 30 patients have completed 28 days of treatment. The Company initiated dosing of the first 20 patients, and is currently enrolling the remaining ten patients. There have been no safety signals to date. Based on the current rate of enrollment, the Company expects to complete one month dosing of the first 30 patients in December 2011, and anticipates releasing interim one month safety and antiviral activity data for the first 30 patients from the Phase IIb trial early in the first quarter of 2012.

Discovery Programs
IDX719, the Company's lead NS5A inhibitor candidate, has shown potent and broad genotypic activity. The Company expects to submit regulatory filings by year end 2011 and begin the clinical program in early 2012.

The Company's novel nucleotide program continues to make significant progress and has generated many preclinical compounds. Given the progress
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SOURCE Idenix Pharmaceuticals, Inc.
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