Navigation Links
Ibrutinib Phase 2 Data: Analyses Show Efficacy with Ibrutinib Monotherapy in Patients with Relapsed or Refractory Mantle Cell or Diffuse Large B-cell Lymphoma
Date:6/16/2013

the ABC subtype, compared to 3.35 months for the GCB subtype (p=0.05).
  • Within the ABC subtype group, only patients who had a CD79B mutation responded to treatment; patients with only an MYD88 mutation did not respond to treatment, suggesting a MYD88-dependent but BCR-independent pathogenesis for some DLBCL tumors.
  • Safety data from 70 patients identified no new safety signals. Grade 3 or higher AEs were seen in greater than 3% of patients and included fatigue (9%), hyponatremia (9%), pneumonia (7%), dehydration (4%), and pleural effusion (4%).
  • "These results indicate the important function BTK plays in the survival of ABC type DLBCL," explained presenting investigator Sven de Vos, M.D., Ph.D., Associate Professor in the Department of Medicine at the UCLA Medical Center, Los Angeles, who reported the results at the EHA Congress today. "Seeing clinically meaningful responses among the ABC subtype was encouraging, as patients at this stage are challenging to treat. Additional trials among this patient group are ongoing."

    The DLBCL study was a Phase 2 multicenter, open-label, study that included 70 patients with relapsed/refractory DLBCL with a median of three prior therapies. All patients underwent gene expression profiling to determine their DLBCL subtype, 29 patients were identified with the ABC subtype, and 20 with the GCB subtype. Patients received ibrutinib 560 mg orally, once a day, until disease progression or unacceptable toxicity. The primary objective of the study was to assess ORR categorized by subtype, with secondary objectives being to assess the safety and tolerability of ibrutinib in people with DLBCL.

    About Ibrutinib
    Ibrutinib is an investigational, oral BTK inhibitor. The effectiveness and safety of ibrutinib alone or in combination with other treatments is being studied in several B-cell malignancies.

    Janssen Biotech, Inc. and Pharmac
    '/>"/>

    SOURCE Janssen
    Copyright©2012 PR Newswire.
    All rights reserved

    Page: 1 2 3 4 5 6

    Related medicine technology :

    1. Pharmacyclics Announces Oral Presentations and Clinical Update of Ibrutinib (PCI-32765) at the 2012 Annual Meeting of the American Society of Clinical Oncology
    2. Pharmacyclics Announces Oral Presentations of Ibrutinib (PCI-32765) at the 17th Congress of the European Hematology Association
    3. Follow-up Results of Phase 2 Study of Investigational Agent, Ibrutinib, Suggest High and Durable Responses in Relapsed/Refractory Mantle Cell Lymphoma
    4. Follow-up Results of Phase 2 Study of Investigational Agent, Ibrutinib, in Relapsed/Refractory Mantle Cell Lymphoma Presented at American Society of Hematology Annual Meeting
    5. Ibrutinib Receives Two Oncology Breakthrough Therapy Designations from U.S. Food and Drug Administration
    6. Pharmacyclics Announces Third Breakthrough Therapy Designation for Ibrutinib from the U.S. Food and Drug Administration
    7. Phase II Ibrutinib Monotherapy Study Shows CLL Patients Achieved Rapid and Sustainable Disease Control Irrespective of Age or High Risk Prognostic Factor
    8. Ibrutinib Expanded Access Program Open to Eligible U.S. Patients with Relapsed or Refractory Mantle Cell Lymphoma
    9. Argos Therapeutics Secures $25 million Series D Financing to Commence Phase 3 ADAPT Study in Patients with Metastatic Renal Cell Carcinoma (mRCC) in Mid-2012
    10. Anthera Announces the Completion of Patient Dosing in Phase 2b PEARL-SC Study
    11. Omthera Pharmaceuticals Announces Positive Top-Line Results from Phase 3 EVOLVE Study
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:3/4/2015)... 4, 2015 Sanomedics , Inc. ... medical technology company that focuses on providing game ... the Company,s subsidiary, Thermomedics, Inc. , has appointed ... Government Sales. LeBel will be reporting to ... and will be responsible for supporting assigned distributor ...
    (Date:3/4/2015)... March 4, 2015  Imprimis Pharmaceuticals, Inc. (NASDAQ: ... development and commercialization of proprietary compounded drug therapies, today ... fiscal year 2014 financial results on Thursday, March 12, ... 4:30 p.m. EDT (1:30 p.m. PDT) on the same ... recent business activities.  The conference call and webcast will ...
    (Date:3/4/2015)... 2015   Mallinckrodt plc (NYSE: ... at the Barclays Global Healthcare Conference at the Loews ... on Wednesday, March 11, 2015. Mark Trudeau, President and Chief ... a session scheduled to begin at 10:45 a.m. Eastern. ... person can find webcast information on Mallinckrodt,s Investor ...
    Breaking Medicine Technology:Sanomedics Hires Scott W. LeBel as Director of Specialty and Government Sales 2Sanomedics Hires Scott W. LeBel as Director of Specialty and Government Sales 3Imprimis Pharmaceuticals to Host its Fourth Quarter and Fiscal Year 2014 Financial Report Conference Call and Webcast on March 12, 2015 at 4:30 p.m. EDT 2Imprimis Pharmaceuticals to Host its Fourth Quarter and Fiscal Year 2014 Financial Report Conference Call and Webcast on March 12, 2015 at 4:30 p.m. EDT 3Mallinckrodt to Present at Barclays Conference March 11 2
    ... LONDON, Aug. 31 Following a recent analysis ... Sullivan presented Lodox Systems (Pty) Ltd (Lodox) with ... Leadership Award".  Statscan, Lodox,s digital x-ray product, stunned ... diagnostic, whole-body x-ray pictures in just 13 seconds. ...
    ... PARK, N.C., and ALISO VIEJO, Calif., Aug. 30 GlaxoSmithKline ... VRX ) announced today the U.S. Food and ... Act (PDUFA) goal date for ezogabine* to 30 November 2010. ... The FDA has not yet completed the review of ...
    Cached Medicine Technology:Frost & Sullivan Applauds the Lodox Statscan Critical Imaging System for Outperforming All Competing Products 2Frost & Sullivan Applauds the Lodox Statscan Critical Imaging System for Outperforming All Competing Products 3Frost & Sullivan Applauds the Lodox Statscan Critical Imaging System for Outperforming All Competing Products 4GSK and Valeant Announce New U.S. FDA PDUFA Goal Date for Ezogabine 2GSK and Valeant Announce New U.S. FDA PDUFA Goal Date for Ezogabine 3
    (Date:3/4/2015)... 2015 With the growing influence of movies, ... our teens and young adults, combined with the increasingly frantic ... to try to keep up with what kids are into ... is replaced on a daily basis. , The same is ... slang that is used to discreetly talk about them, are ...
    (Date:3/4/2015)... March 04, 2015 Starting February 2015, ... and PRK procedures at their new location in Surrey. ... Joseph King and Dr. Gabriel Chu also provide comprehensive ... Surrey is named Fraser Valley Cataract and Laser (FVCL). ... by the College of Physicians and Surgeons of British ...
    (Date:3/4/2015)... March 04, 2015 The print component ... The San Francisco Chronicle with a circulation of approximately ... Its digital component is distributed nationally through a vast ... news sites and partner outlets. To explore the digital ... , Milorganite is composed of heat-dried microbes that have ...
    (Date:3/4/2015)... (PRWEB) March 04, 2015 As ... Endometriosis can be a painful condition in ... spreading outside of the uterus leading to very unpleasant ... families. Endometriosis can have a terrible effect on women’s ... is also the most common cause of infertility in ...
    (Date:3/4/2015)... March 04, 2015 The popular all-natural ... their new L-Style Revolution™ Program. The customized program provides ... women of all health and fitness levels to follow ... faster than traditional methods. , “We’re really proud to ... plans based on award winning techniques to help people ...
    Breaking Medicine News(10 mins):Health News:Per Wickstrom Offers Guide to Parents for Keeping Youth Sober 2Health News:King LASIK relocates to Surrey, British Columbia 2Health News:Advanced Fertility Center of Texas Brings Awareness to the Month of March-Endometriosis Awareness Month 2Health News:Advanced Fertility Center of Texas Brings Awareness to the Month of March-Endometriosis Awareness Month 3Health News:The Makers of Liporidex, The Popular Sports Nutrition Supplement Brand, Launches Its New L-Style Revolution™ Diet & Exercise Program That Promises Turbo Charged Results 2
    ... a charge on cancer patients for powerful, intravenous medications, ... seriously considered by Ontario's Health Minister. ,George Smitherman ... due diligence and obviously we're closer to having a ... right thing said in a telephone interview yesterday. I ...
    ... Stroke Association has released a set of new recommendations ... published in the rapid access issue of Stroke: Journal ... third leading cause of death and a major source ... 700,000 people in the United States suffer a stroke, ...
    ... College of Midwives has revealed that most mothers prefer their ... of the 1400 female respondents said they would opt for ... in four fathers who were inside the delivery room felt ... in six mothers felt their husbands presence to be a ...
    ... hours for medical subjects such as anatomy in Australian ... medical students are unable to locate vital body parts//. ... with another. In addition to the subject of anatomy, ... hours for biochemistry, pathology, physiology and other basic sciences. ...
    ... (HLL), has launched the Female Condom (FC) in India. It ... Health Company to market// their female condoms in India under ... years of research before being able to launch the condom ... in the first year. A pair of Confidom will cost ...
    ... gaining popularity among the teenagers in the recent years. But ... deny bluntly that they ever took such vows. // ... are a good way of gauging how well they adhere ... take the form of public or written declarations to remain ...
    Cached Medicine News:Health News:How To Prevent A Stroke 2Health News:How To Prevent A Stroke 3Health News:How To Prevent A Stroke 4Health News:Australian Medical Students Lack Anatomy Knowledge 2Health News:Teenagers Often Deny Taken ‘Virginity Pledges 2
    A professionally designed instrument for obtaining accurate measurements of the corneal curvature. The convenient configuration also facilitates measuring contact lens curvatures....
    ... who need to move their imaging system from ... solution. The IMAGEnet Portable System features a rugged ... monitor. This portable PC solution can be coupled ... be tailored to your multi-site imaging needs. The ...
    ... 32-bit software package (IMAGEnet 2000) with the ... you a fast reliable solution to in-office ... of the Compaq EN Series small business ... and a formidable grouping of other top ...
    ... Topcon combines the best 32-bit software ... name hardware offerings to bring you a ... This cost efficient "mid-resolution" package takes advantage ... computer, adds the latest graphics capture technology ...
    Medicine Products: