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ISTA Pharmaceuticals Highlights Bepreve(TM) Clinical Data at the 2009 Annual Meeting of the American College of Allergy, Asthma & Immunology (ACAAI)
Date:11/9/2009

Authors: G. L. Torkildsen, J. I. Williams, J. A. Gow, P. J. Gomes, T. R. McNamara

The Conjunctival Allergen Challenge (CAC) Model of Allergic Conjunctivitis - Does Assumption of a Normal Data Distribution Influence the Means for Evaluating Clinical and Statistical Significance?

Authors: K. S. Kennedy, J. I. Williams, J. A. Gow, M. B. Abelson, T. R. McNamara

Abstracts are published in the November issue of Annals of Allergy, Asthma & Immunology and are available online at www.annallergy.org.

About Bepreve(TM) (bepotastine besilate ophthalmic solution) 1.5%

Bepreve is a non-sedating, highly selective antagonist of the histamine (H1) receptor. It has a stabilizing effect on mast cells, and it suppresses the migration of eosinophils into inflamed tissues. The compound's primary mechanisms of action are believed to make it an effective treatment against ocular itching associated with allergic conjunctivitis.

Bepreve was approved by the U.S. Food and Drug Administration in September 2009 for the treatment of ocular itching associated with allergic conjunctivitis. Bepotastine has been approved in Japan for systemic use in the treatment of allergic rhinitis since 2000 and urticaria/pruritus since 2002. It is marketed in Japan by Mitsubishi Tanabe Pharma Corporation (formerly Tanabe Seiyaku Co., Ltd.) under the brand name TALION®. TALION was co-developed by Tanabe Seiyaku and Ube Industries, Ltd., who discovered bepotastine. In 2001, Tanabe Seiyaku granted Senju Pharmaceutical Co., Ltd., exclusive worldwide rights, with the exception of certain Asian countries, to develop, manufacture and market bepotastine for ophthalmic use. In 2006, ISTA licensed the exclusive North American rights from Senju to an eye drop formulation of bepotastine for the treatment of allergic conjunctivitis. In 2007, ISTA licensed exclusive North
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SOURCE ISTA Pharmaceuticals, Inc.
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