Navigation Links
ISIS Reports Phase 1 Data Demonstrating ISIS-TTRRx Produces Significant Reductions in TTR Protein
Date:1/5/2012

life is substantially compromised.  Although, liver transplant replaces mutant TTR, amyloid formation continues due to accumulation of normal TTR protein," said Richard Geary, Ph.D., Senior Vice President of Development at Isis.  "ISIS-TTRRx blocks the production of both normal and mutant TTR, thereby preventing further amyloid accumulation, which may prevent, and potentially reverse, disease progression."

The Phase 1 study of ISIS-TTRRx was a blinded, randomized, placebo-controlled, dose-escalation study designed to assess the safety and pharmacokinetic profile of ISIS-TTRRx in healthy volunteers.  ISIS-TTRRx was evaluated in single and multiple doses ranging from 50 mg per week up to 400 mg per week.  After only four weeks of dosing, subjects in the 200 mg and 400 mg multiple-dose cohorts displayed a mean reduction of 44 percent and 81 percent in TTR levels, respectively.  ISIS-TTRRx was generally well tolerated in all subjects. 

"In this study, we observed substantial dose-dependent reductions in TTR protein of greater than 80 percent.  Based on the mechanism of action and the early data we have presented, we believe that ISIS-TTRRx could provide benefit to patients with FAP," said Brett Monia, Ph.D., Senior Vice President, Drug Discovery and Corporate Development of Isis.  "Together with our partner GSK, we are finalizing the development plan for ISIS-TTRRx, which is intended to achieve an efficient route to registration.  Our next clinical study for ISIS-TTRRx will begin in 2012 and evaluate the effects of the drug on disease progression and other measures of disease burden/improvements on quality of life in patients with FAP."

ABOUT ISIS-TTRRx
Transthyretin amyloidosis is a genetic disease in which the patient inherits a mutant gene that produces a misfolded form of TTR, which progressively accumulates in tissues, impairing their function.  In patients with transthyretin amyloid
'/>"/>

SOURCE Isis Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related medicine technology :

1. InterMune Reports Preliminary Fourth Quarter 2011 Esbriet® (pirfenidone) Revenue and Other Recent Business Highlights
2. Quark Pharmaceuticals Reports Favorable Interim Results from Phase I Clinical Study of QPI-1007 in Patients with Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)
3. Cardium Reports on Renewed Compliance With NYSE Amex Exchange Listing Guidelines
4. Optimer Pharmaceuticals Reports Inducement Grants Under NASDAQ Listing Rule 5635(c)(4)
5. Solos Endoscopy, Inc. Reports Significant Sales From Its MammoView® Instrument Line
6. VIVUS Reports Topline Findings From FORTRESS
7. Angeion Corporation Reports Fourth Quarter and Fiscal Year 2011 Operating Results
8. Champions Oncology Reports Fiscal 2012 Second Quarter Financial Results
9. American Pacific Reports Fiscal 2011 Results
10. Avanir Pharmaceuticals Reports Fiscal 2011 Fourth Quarter and Year End Financial Results
11. Cantel Medical Reports 25% Increase in Net Income - EPS of $0.35 vs. $0.29 - for Quarter Ended October 31, 2011 on 30% Sales Increase
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2013)... , May 18, 2013 Faruqi & ... is investigating potential securities fraud at AVEO Pharmaceuticals, ... (Logo: http://photos.prnewswire.com/prnh/20120119/MM38856LOGO ) ... its executives violated federal securities laws by issuing ... Phase III drug trials for Tivopath (tivozanib) (titled ...
(Date:5/17/2013)... 2013  Sorrento Therapeutics, Inc. (OTCBB: SRNE; or ... Small Business Technology Transfer Research (STTR) grant (#1R42AI098182-02) ... Diseases (NIAID), a division of the National Institutes ... human antibody therapeutics to combat Staphylococcus aureus ... including methicillin-resistant S. aureus (MRSA), was ...
(Date:5/17/2013)... 2013  Sony Biotechnology Inc. ("Sony") today announced the launch ... 130um sorting chip.  Sony will also be exhibiting its newly ... Cell Sorter, the EC800 flow cytometer, and new SP6800 Spectral ... which will be held at the San Diego ... , from May 20 - 22.  ...
Breaking Medicine Technology:Faruqi & Faruqi, LLP Encourages Investors Who Suffered Losses In Excess Of $100,000 Investing In AVEO Pharmaceuticals, Inc. To Contact The Firm 2Sorrento Therapeutics, Inc. announces its approach to developing human antibody therapeutics against MRSA receives continued support from the National Institute of Allergy and Infectious Diseases 2Sorrento Therapeutics, Inc. announces its approach to developing human antibody therapeutics against MRSA receives continued support from the National Institute of Allergy and Infectious Diseases 3Sorrento Therapeutics, Inc. announces its approach to developing human antibody therapeutics against MRSA receives continued support from the National Institute of Allergy and Infectious Diseases 4Sony Delivers New Technology for Science to CYTO 2013 2
... Club (FC) Barcelona, FC Barcelona Foundation, and ... three-year partnership today to energize the global fight to ... life-saving vaccines.  Bill Gates, co-chair of the Bill & ... Rosell and Manager Josep Guardiola, announced the partnership at ...
... China, July 28, 2011 /PRNewswire-Asia/ -- China Kanghui Holdings (NYSE: ... domestic developer, manufacturer and marketer of orthopedic implants in China, ... 2011 financial results on August 16, 2011, before the market ... 8:00 a.m. ET on August 16, 2011 to discuss second ...
Cached Medicine Technology:Futbol Club Barcelona and the Bill & Melinda Gates Foundation Team Up to End Polio and Give Every Child an Equal Shot at Life 2Futbol Club Barcelona and the Bill & Melinda Gates Foundation Team Up to End Polio and Give Every Child an Equal Shot at Life 3China Kanghui Holdings to Report Second Quarter 2011 Financial Results on August 16, 2011 2
(Date:5/20/2013)... (PRWEB) May 20, 2013 FixturesAndDisplays.com, the ... comprehensive selection of high-quality retail clothing display options to ... and upscale retailers. Their expansive product line includes ... broad range of mannequin options. Recently ... its most popular models in reformulated “green” versions. ...
(Date:5/20/2013)... As a mother to three children, Lacy Arnold knows firsthand how ... fit, healthy lifestyle. She also knows the pains and frustrations associated ... of bricks about a year after giving birth to my first ... had lost control of my health and weighed over 200 pounds ... energy to care for my sweet little girl, and I was ...
(Date:5/20/2013)... 2013 Today is the last day ... Answers Webinar tomorrow. Job seekers cannot afford to ... career coach, will show job seekers what hiring managers ... also learn the perfect interview answers to the four ... that will get them hired. Job seekers will be ...
(Date:5/19/2013)... Alonso Krangle LLP, an experienced plaintiffs’ ... York woman in a Paternity Petition against Herschel ... (NFL). According to an April 23rd filing in New ... of paternity, order of support and further relief as may ... Walker. (Docket No. P-18821-13) , Herschel Walker, is a ...
(Date:5/19/2013)... 2013 The special introductory offer for ... end soon. "We are so excited to introduce our ... Sublime Beauty®. "It is a pleasure to use, it ... it also moisturizes the skin. One of the powerful ... that is very successful in clinical studies." , Collagen ...
Breaking Medicine News(10 mins):Health News:FixturesAndDisplays.com Offers Line of ‘Green’ Mannequins for Retail Displays 2Health News:FixturesAndDisplays.com Offers Line of ‘Green’ Mannequins for Retail Displays 3Health News:New Program Helps Busy Moms Become Healthier, Lose Weight, and Feel Great 2Health News:Today Is the Last Day to Register for Tomorrow’s Perfect Interview Answers Webinar From Career Confidential 2Health News:New York Woman in Paternity Petition Against Former NFL Running Back, Herschel Walker, Alonso Krangle LLP Representing Petitioner 2Health News:New York Woman in Paternity Petition Against Former NFL Running Back, Herschel Walker, Alonso Krangle LLP Representing Petitioner 3
... 10, 2011 In 1980 in the United States, approximately ... By 2007 that figure had increased to 14%. Women over ... with trisomy 21. In a study published online today in ... researchers from the Sequenom Center for Molecular Medicine confirmed that ...
... like shots or needles, you,re in luck. New research published ... gives the development of new oral vaccinations a shot in ... mice. In addition, this research report also offers a tantalizing ... even if direct injections into the body fail to cause ...
... HealthDay Reporter , WEDNESDAY, Feb. 9 (HealthDay News) -- Surgery ... cord birth defect known as spina bifida may be most ... groundbreaking -- research suggests. When successful, the surgery could ... not, experts say, since twice as many spina bifida-affected children ...
... , THURSDAY, Feb. 10 (HealthDay News) -- Low ... associated with higher rates of obesity, researchers report. The ... in cities tend to be thinner because they have more ... have to drive most everywhere they go. For this ...
... FRANCISCO (February 10, 2011) In a study to ... (SMFM) annual meeting, The Pregnancy Meeting , in San ... rats, the use of magnesium sulfate (Mg) significantly reduced ... maternal infection. Magnesium sulfate is sometimes used during ...
... 10, 2011) In a study to be presented today ... Pregnancy Meeting , in San Francisco, researchers will present findings ... mothers in situations when labor has to be induced, that ... There are many reasons that labor may need to ...
Cached Medicine News:Health News:Noninvasive test for trisomy 21 closer at hand 2Health News:Salivary glands as organs of immunity: New research makes oral immunization easier to swallow 2Health News:Fetal Surgery Could Boost Outcomes in Severe Spina Bifida 2Health News:Fetal Surgery Could Boost Outcomes in Severe Spina Bifida 3Health News:Fetal Surgery Could Boost Outcomes in Severe Spina Bifida 4Health News:Study finds magnesium sulfate may offer protection from cerebral palsy 2Health News:When first-time mothers are induced, breaking the amniotic membrane shortens delivery time 2
Store microscope slides with ease, speed, efficiency....
... drawers for just about everything imaginable that might ... Each box is designed for long term storage ... of wood over metal systems is overlooked, while ... subtle kind of desiccator and insulator, providing an ...
A prepared Microscope Slide Cataloging and Storage System....
... resistant, plastic covered corrugated boxes interlock ... up to 500 lbs of overhead ... accommodates 2000 slides or 500 tissue ... requirements. Come unassembled boxes require minimal ...
Medicine Products: