Navigation Links
ISIS Reports Phase 1 Data Demonstrating ISIS-TTRRx Produces Significant Reductions in TTR Protein
Date:1/5/2012

life is substantially compromised.  Although, liver transplant replaces mutant TTR, amyloid formation continues due to accumulation of normal TTR protein," said Richard Geary, Ph.D., Senior Vice President of Development at Isis.  "ISIS-TTRRx blocks the production of both normal and mutant TTR, thereby preventing further amyloid accumulation, which may prevent, and potentially reverse, disease progression."

The Phase 1 study of ISIS-TTRRx was a blinded, randomized, placebo-controlled, dose-escalation study designed to assess the safety and pharmacokinetic profile of ISIS-TTRRx in healthy volunteers.  ISIS-TTRRx was evaluated in single and multiple doses ranging from 50 mg per week up to 400 mg per week.  After only four weeks of dosing, subjects in the 200 mg and 400 mg multiple-dose cohorts displayed a mean reduction of 44 percent and 81 percent in TTR levels, respectively.  ISIS-TTRRx was generally well tolerated in all subjects. 

"In this study, we observed substantial dose-dependent reductions in TTR protein of greater than 80 percent.  Based on the mechanism of action and the early data we have presented, we believe that ISIS-TTRRx could provide benefit to patients with FAP," said Brett Monia, Ph.D., Senior Vice President, Drug Discovery and Corporate Development of Isis.  "Together with our partner GSK, we are finalizing the development plan for ISIS-TTRRx, which is intended to achieve an efficient route to registration.  Our next clinical study for ISIS-TTRRx will begin in 2012 and evaluate the effects of the drug on disease progression and other measures of disease burden/improvements on quality of life in patients with FAP."

ABOUT ISIS-TTRRx
Transthyretin amyloidosis is a genetic disease in which the patient inherits a mutant gene that produces a misfolded form of TTR, which progressively accumulates in tissues, impairing their function.  In patients with transthyretin amyloid
'/>"/>

SOURCE Isis Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. InterMune Reports Preliminary Fourth Quarter 2011 Esbriet® (pirfenidone) Revenue and Other Recent Business Highlights
2. Quark Pharmaceuticals Reports Favorable Interim Results from Phase I Clinical Study of QPI-1007 in Patients with Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)
3. Cardium Reports on Renewed Compliance With NYSE Amex Exchange Listing Guidelines
4. Optimer Pharmaceuticals Reports Inducement Grants Under NASDAQ Listing Rule 5635(c)(4)
5. Solos Endoscopy, Inc. Reports Significant Sales From Its MammoView® Instrument Line
6. VIVUS Reports Topline Findings From FORTRESS
7. Angeion Corporation Reports Fourth Quarter and Fiscal Year 2011 Operating Results
8. Champions Oncology Reports Fiscal 2012 Second Quarter Financial Results
9. American Pacific Reports Fiscal 2011 Results
10. Avanir Pharmaceuticals Reports Fiscal 2011 Fourth Quarter and Year End Financial Results
11. Cantel Medical Reports 25% Increase in Net Income - EPS of $0.35 vs. $0.29 - for Quarter Ended October 31, 2011 on 30% Sales Increase
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... , Aug. 21, 2014 /PRNewswire-iReach/ -- ... Equipment, Inc. for the third straight year, No. ... 500|5000, an exclusive ranking of the nation,s fastest-growing ... look at the most important segment of the ... Timberland, Dell, Domino,s Pizza, LinkedIn, Zillow, and many ...
(Date:8/21/2014)... 21, 2014 BreedIT Corp., ... the exclusive worldwide license holder and distributor of ... and researchers, today is pleased to announce the ... Seach Ltd, a leading Israeli medical Cannabis breeder. ... develop new breeds of medical Cannabis to meet ...
(Date:8/21/2014)... FRANCISCO , Aug. 21, 2014 /PRNewswire/ ... Food and Drug Administration (FDA) has granted ... detect atrial fibrillation (AFib), the most common ... process (algorithm) instantly detects if patients are ... taken on the mobile phone based AliveCor® ...
Breaking Medicine Technology:Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 2Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 2BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 4AliveCor Receives First FDA Clearance to Detect a Serious Heart Condition in an ECG on a Mobile Device 2
(Date:8/21/2014)... August 21, 2014 Xarelto lawsuit ( ... patients to suffer uncontrollable internal bleeding and other serious ... LLP reports. According to court documents, a wrongful death ... Court, Easter District of New York by the family ... bleeding event that was allegedly caused by Xarelto. Among ...
(Date:8/21/2014)... NY (PRWEB) August 21, 2014 ... products manufactured by Boston Scientific has begun in ... first bellwether trial. The Rottenstein Law Group LLP, ... women with claims of harm stemming from the ... a claim for compensation for injuries suffered at ...
(Date:8/21/2014)... Revista, a one-stop source for healthcare ... is “on a roll.” Today, the Annapolis-based company ... Southeast, Mid-Atlantic and Midwest areas of the country ... available, comprehensive medical property database tracking these regions. ... including existing and recently added, is 34,549. This ...
(Date:8/21/2014)... 2014 (HealthDay News) -- In a new review of ... avoid eating tuna due to concerns about mercury exposure. ... second only to shrimp as the most commonly eaten ... to avoid all tuna," Jean Halloran, director of food ... Consumer Reports, said in a news release from the ...
(Date:8/21/2014)... August 21, 2014 Sasha is a 10 ... Sasha is getting a little older, and is having trouble ... Sasha just happens to have an owner who purchased a ... had an accident, and could no longer get up and ... her finished basement. She had tried a stair lift, ...
Breaking Medicine News(10 mins):Health News:Xarelto Lawsuits Mount With New Filing in New York Federal Court, Bernstein Liebhard LLP Reports 2Health News:Xarelto Lawsuits Mount With New Filing in New York Federal Court, Bernstein Liebhard LLP Reports 3Health News:Xarelto Lawsuits Mount With New Filing in New York Federal Court, Bernstein Liebhard LLP Reports 4Health News:Transvaginal Mesh Lawsuit News: Second Boston Scientific Mesh Bellwether Trial Begins, The Rottenstein Law Group LLP Reports 2Health News:Revista Medical Property Data Now Available for the Mid-Atlantic, Southeast and Midwest Regions 2Health News:Revista Medical Property Data Now Available for the Mid-Atlantic, Southeast and Midwest Regions 3Health News:Revista Medical Property Data Now Available for the Mid-Atlantic, Southeast and Midwest Regions 4Health News:Revista Medical Property Data Now Available for the Mid-Atlantic, Southeast and Midwest Regions 5Health News:Consumer Reports Advises Pregnant Women to Avoid Tuna 2Health News:Sasha Gets a Butler Mobility Inclined Platform Lift 2
... circulating blood and important in blood clotting, can promote ... into the brain, triggering inflammation that leads to MS-related ... Diego (UCSD) School of Medicine have identified a fibrin-derived ... models of MS, reducing MS symptoms. ,“Current ...
... A study by Drs Benjamin Kile and David Huang found ... This discovery is sure //to raise the hope of formulating ... platelets stored in blood banks. This will in turn increase ... ,An undesirable side effect of cancer chemotherapy ...
... found if given a choice of exercising alone, with ... age, most adults would rather exercise with others in ... provide useful insight into the preferences of older exercisers, ... initiatives [in communities around the world],” said lead researcher ...
... have come out with study results that encourage health care ... marked by the presence of tumor cells in ... may be a definite clue to chances of reccurence ... with risks of the cancer staging a comeback. ...
... wife Elizabeth Edwards has been diagnosed with// a recurrent case ... right rib bone and hence classified as metastatic or stage ... and underwent treatment, was cancer free for the last two ... conference in North Carolina that she had sought medical treatment ...
... study finds that improving the institutional culture (ethos) of ... on bad habits like// smoking, drinking, drug abuse and ... of Hygiene and Tropical Medicine's Centre for Research on ... teenage pregnancy are major public health challenges and argue ...
Cached Medicine News:Health News:Inhibiting Blood to Save the Brain 2Health News:Improved Platelet Life Span Increases Better Patient Care 2Health News:Exercising With Peers Has Added Appeal 2Health News:Doctors Warned to Keep Track of Tumorous Lymph Nodes 2Health News:Doctors Hopeful for Elizabeth Edwards 2Health News:Improve School Ethos to Combat Teen Evils 2
... King LT™ is a superior, disposable supraglottic ... advances in materials and design to provide ... LT™ emergency airway is a safe, reliable, ... emergency ventilation when direct laryngoscopy is not ...
All oral and nasal airways are manufactured with smooth, rounded edges for increased patient comfort and safety., ,Portex® offers a broad selection of airways for a variety of clinical applicati...
... Available in even sizes 20-36F. Single use. ... patient comfort. The Latex-Free Robertazzi is the ... offering the best solution for latex sensitivity. ... offer a quality latex-free product as your ...
Bag of 9 airways 20-36 French (1234) or 4 airways 12-18 French (1233). Includes four foil packages of lubricating jelly....
Medicine Products: