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ISIS Initiates Phase 1 Clinical Trial of ISIS-SOD1Rx in Patients With ALS
Date:3/5/2010

CARLSBAD, Calif., March 5 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) announced today that it has initiated a Phase 1 study of ISIS-SOD1Rx in patients with an inherited, aggressive form of Lou Gehrig's disease also known as familial amyotrophic lateral sclerosis (ALS).  Approximately 20 percent of all familial ALS cases are caused by a mutant form of superoxide dismutase, or SOD1.  ISIS-SOD1Rx is an antisense drug designed to inhibit the production of SOD1.  The ALS Association and the Muscular Dystrophy Association are providing funding for the development of ISIS-SOD1Rx.  

"There is a desperate need for new and more substantive treatments for ALS patients.  The mission of the Northeast ALS Consortium is to help advance new therapeutic options for patients with ALS, and I am very pleased to be a co-chair on this
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SOURCE Isis Pharmaceuticals, Inc.
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