Navigation Links
INVEGA(TM) Significantly Reduced Symptoms of Schizophrenia Compared to SEROQUEL(R) in Acutely Ill, Hospitalized Patients
Date:10/13/2007

monotherapy phase (primary endpoint) followed by a four-week additive therapy phase (secondary endpoint). During the four-week phase, patients could be prescribed additional psychotropic therapy as clinically indicated to manage psychiatric symptoms.

Recent trials in hospitalized patients have suggested the need for higher doses in the treatment of acute patients(2). This study examined the effects of recommended labeled doses while taking into account common clinical practice for this patient population. INVEGA was initiated at the recommended starting dose of 6mg/day (days one to three) increasing to 9 mg/day on day four. As these patients were acutely ill, there was an option to increase the dose to 12 mg/day on day eight. SEROQUEL was titrated to 600 mg/day by day five with an option to increase the dose to 800 mg/day on day eight. Because this study enrolled severely ill patients with recent onset of symptoms, patients were more likely to require doses near the upper end of the recommended ranges to control their symptoms. The average doses during the monotherapy phase were 10.4 mg/day for INVEGA and 690.9 mg/day for SEROQUEL.

The primary efficacy endpoint was total change in PANSS score from baseline to the end of the monotherapy phase (day 14). The average PANSS score at baseline was 102.8 (plus or minus 13.1) for the INVEGA group, 101.6 (plus or minus 13.5) for the SEROQUEL group, and 103.8 (plus or minus 15.7) for the placebo group. At the end of the monotherapy phase (day 14), the change in the total score from baseline was: -23.4 (1.8) for INVEGA, - 17.1(1.8) for SEROQUEL and -15.0 (2.2) for placebo, with INVEGA showing a significant reduction in symptoms over both SEROQUEL (p < less than > 0.001) and placebo (p < less than > 0.001).

In a separate analysis, INVEGA(TM) also produced a statistically significant improvement in the reduction in the individual symptom domains of the PANSS, which includes positive symptoms, negative symptoms,
'/>"/>

SOURCE Janssen, L.P. and Johnson & Johnson
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Liraglutide provides significantly better glucose control than insulin glargine in phase 3 study
2. Arterial Plaque Significantly Reduced in Women Age 50-59 Taking Hormones, Says New Analysis of Womens Health Initiative Data
3. Prexige Study Shows Significantly Less Impact on Blood Pressure Than Ibuprofen in Osteoarthritis Patients with Controlled Hypertension
4. Lumiracoxib Study Showed Significantly Less Impact on Blood Pressure Than Ibuprofen in Osteoarthritis Patients with Controlled Hypertension
5. Actemra (tocilizumab) Significantly Improves Symptoms of Rheumatoid Arthritis Compared to a Current Standard of Care
6. Next Safety, Inc.s Innovative Drug Delivery System Will Replace Cigarettes and Significantly Advance Pulmonary Medication Delivery
7. Ivivis PEMF Technology Significantly Improves Neuron Survival in Parkinsons Disease Model, Study Finds
8. Mercks Investigational Migraine Treatment MK-0974 Significantly Improved Migraine Pain on Several Efficacy Measures in a Phase II Study
9. The Eloxatin-Based Regimen (FOLFOX4) Significantly Improved Progression Free Survival When Given Before and After Surgery in Patients With Resectable Liver Metastases From Colorectal Cancer
10. Nexavar Significantly Extends Overall Survival by 44% in Liver Cancer Patients
11. MabThera Significantly Extends Survival And Cures More Patients With Aggressive Lymphoma Than Chemotherapy Alone
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... , July 31, 2015 According ... Market by Product (Bioimpedance Analyzers (BIA), Dual-Energy X-ray Absorptiometry ... Weighing) - Global Analysis & Forecast to 2019", published ... pegged at $911.1 Million 2014 and is estimated to ... CAGR of 9.4% from 2014 to 2019. ...
(Date:7/30/2015)... 2015 IRIDEX Corporation (NASDAQ: IRIX ) ... 2015 financial results after the market closes on ... release, the Company will host a conference call with ... on Thursday, August 6, 2015 to ... developments. Interested parties may access the live ...
(Date:7/30/2015)... July 30, 2015  Unichem Pharmaceuticals ( USA ... of Hydrochlorothiazide tablets 25 mg 1000-count bottle to the ... precautionary measure due to the identification of a Clopidogrel ... The risk associated with mistakenly taking a ... increased probability of experiencing Clopidogrel,s side effects which include ...
Breaking Medicine Technology:Body Composition Analyzers Market Worth $1,425.7 Million by 2019 2Body Composition Analyzers Market Worth $1,425.7 Million by 2019 3Body Composition Analyzers Market Worth $1,425.7 Million by 2019 4IRIDEX Announces Second Quarter 2015 Conference Call and Release Date 2Unichem Pharmaceuticals (USA), Inc. Issues a Voluntary Nationwide Recall of Hydrochlorothiazide Tablets Due to the Potential Presence of Foreign Tablets 2
(Date:7/31/2015)... ... ... is a reputable source of authentic tickets for the 2015 iHeart Radio Music Festival ... of music will have an act they are excited to see at this two-day festival. ... will perform: Sam Smith, Coldplay, Kenny Chesney, The Who, Jason Derulo, Demi Lovato, Duran ...
(Date:7/31/2015)... ... 2015 , ... Ticket Down is a reliable source for authentic tickets for ... Park. The festival will end on Sunday, August 2nd. , Music ... Lollapalooza. This unique and unbelievably popular festival attracts the best in entertainment from ...
(Date:7/31/2015)... ... July 31, 2015 , ... The 2nd annual Ride to Fight On will ... October 3, 2015. The Ride to Fight On is a cycling fundraiser that benefits ... The West Clinic and The University of Tennessee Health Science Center. A health and ...
(Date:7/31/2015)... ... 31, 2015 , ... Facebook, Twitter, Linkedin and blogs are ... media profiles to better connect with the public. The agency website at ... insights and opinions. The Rally Insurance Group, Inc.’s pledge to provide effortless ways ...
(Date:7/31/2015)... ... July 31, 2015 , ... According to the article published July 27 on ... courthouse was contained and extinguished by the city’s fire department before it caused major damage ... the time of the fire, and it was a fire alarm system that tipped off ...
Breaking Medicine News(10 mins):Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 3Health News:Cheap 2015 Lollapalooza Tickets: Ticket Down Slashes Ticket Prices on Lollapalooza Tickets at Grant Park in Chicago for Saturday, August 1st and Sunday, August 2nd 2Health News:West Cancer Center Announces 2nd Annual Ride to Fight On 2Health News:West Cancer Center Announces 2nd Annual Ride to Fight On 3Health News:Rally Insurance Group, Inc. Connects to Customers Through Re-branded Social Media Profiles 2Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 2Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 3
... pioneer in the use of robotics for minimally invasive cardiac ... chief of cardiac surgery. With his arrival, BMC has ... country, and the only hospital in Boston, to offer robot-assisted ... for coronary artery disease (the most common form of heart ...
... Film to IDC Digital ... ... (TSX: IDL), the global leader in the rapidly growing market for,digital ... purchased IDC,s X2200, X1590, and X1600 Plus direct,digital radiography (DR) systems ...
... April 7, 2008 Advanced Life Sciences,Holdings, Inc. (Nasdaq: ... a,conference call and live webcast at 8:30 am (EDT) ... will be to discuss the Company,s April 7, 2008,meeting ... the planned NDA,submission for the Company,s novel once-a-day oral ...
... a newly developed algorithm has significantly advanced understanding ... common primary brain tumor in adults, human glioblastoma ... the April issue of the journal Cancer Cell, ... previously linked with GBM, thereby elucidating new directions ...
... BOSTON--The search for cancer genes is increasingly a matter ... to distinguish genes actually involved in the disease from ... hundreds or thousands of genetic irregularities in tumor tissue, ... true culprits. , In a new study in the ...
... April 7, 2008 Pennsylvania,Secretary of Health Dr. Calvin ... Harrisburg by urging United Way executives to help change ... will be meeting with those who are working to ... lack of health,insurance has an enormous impact on the ...
Cached Medicine News:Health News:Robot-assisted minimally-invasive CABG surgery 2Health News:Saratoga Hospital Purchases Three IDC DR Systems 2Health News:Saratoga Hospital Purchases Three IDC DR Systems 3Health News:Advanced Life Sciences to Host Conference Call to Discuss April 7th Meeting with FDA 2Health News:Advanced Life Sciences to Host Conference Call to Discuss April 7th Meeting with FDA 3Health News:New regulatory circuit identified for aggressive, malignant brain tumor 2Health News:Data-handling technique finds genes to be team players in curbing brain cancer cell growth 2Health News:Data-handling technique finds genes to be team players in curbing brain cancer cell growth 3Health News:Pennsylvania Health Secretary Focuses on Changing the Climate of Health Care During National Public Health Week 2
... ODEI750D cameras are a new generation of flexible ... digital and video imaging. Images are captured by ... both video and digital formats. Video signals include ... are sent to the PC as uncompressed TIFF ...
Bench Top Vertical Airflow Cabinets Production Protection...
Bench Top Horizontal (clean bench) Airflow Cabinet...
... This sealed isolation chamber provides a ... repackaging sterile pharmaceuticals, in accord with ... Class 100 (ISO 5) cleanliness conditions ... antechamber, IV rod and tilt-up front ...
Medicine Products: