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INSYS Therapeutics, Inc. Announces Positive Phase III Efficacy Trial Results for Fentanyl Sublingual Spray
Date:3/8/2010

Background on Breakthrough Cancer Pain and the Fentanyl SL Spray

Breakthrough cancer pain is a common, debilitating feature of chronic pain, seen in approximately 75% of patients with cancer. It is a severe pain flare-up that "breaks through" the relief provided by around-the-clock analgesics. Unlike persistent cancer pain, breakthrough cancer pain is generally rapid in onset and can last a couple hours with the average episode averaging thirty minutes. Patients with cancer may experience between two and seven episodes of breakthrough cancer pain a day.  It is estimated that over a half-million people in the U.S. with cancer suffer from breakthrough pain, however, only about 25,000 receive a treatment approved for the condition.

INSYS' Fentanyl SL spray provides quick administration of Fentanyl, a potential treatment for breakthrough cancer pain. The single unit dose device is formulated with the opioid narcotic fentanyl for delivery to the oral mucosa.  Fentanyl belongs to the group of medicines called narcotic analgesics, which are used to relieve pain.

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