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INCIVO® (Telaprevir) SVR Rates Unaffected by Ribavirin Dose Reduction in Treatment Naïve and Previously Treated Patients With Genotype-1 Chronic HCV
Date:4/18/2012

sup>] Chronic infection with HCV can lead to liver cancer and other serious and fatal liver diseases.[13] About one-quarter of the liver transplants performed in 25 European countries in 2004 were attributable to HCV.[12] The previously accepted standard treatment for HCV is peginterferon alfa combined with ribavirin,[14] however this only clears the virus for 40-50 percent of genotype-1 chronic HCV patients.[14,15]

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At Janssen, we are dedicated to addressing and solving some of the most important unmet medical needs of our time in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Driven by our commitment to patients, we bring innovative products, services and solutions to people throughout the world.

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References:

  1. Sulkowski, M S et al.Ribavirin dose modification in treatment-naïve and previously treated ppatients who received telaprevir combination treatment: no impact on sustained virologic response in phase 3 studies. Poster presented at the 47th Annual Meeting of the European Association of Study of the Liver (EASL)2012
  2. Copegus® Summary of Product Characteristics, updated 2012
  3. Jacobson, I et al. Telaprevir for Previously Untreated Hepatitis C Virus Infection. N Engl J Med. 2011;364:2405-16. (ADVANCE)
  4. Sherman, K et al. Response-Guided Telaprevir Combination Treatment for Hepatitis C Virus Infection. N Engl J Med. 2011;365:1014-24. (ILLUMINATE)
  5. Zeuzem,S et al. Telaprevir for Retreatment of HCV Infection. N Engl J Med. 2011;364:2417-28.(REALIZE)
  6. Incivo® Summary of Product Characteristics, updated 2011
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SOURCE Janssen Pharmaceutica N.V
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