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INCIVO® (Telaprevir) SVR Rates Unaffected by Ribavirin Dose Reduction in Treatment Naïve and Previously Treated Patients With Genotype-1 Chronic HCV
Date:4/18/2012

sup>] Chronic infection with HCV can lead to liver cancer and other serious and fatal liver diseases.[13] About one-quarter of the liver transplants performed in 25 European countries in 2004 were attributable to HCV.[12] The previously accepted standard treatment for HCV is peginterferon alfa combined with ribavirin,[14] however this only clears the virus for 40-50 percent of genotype-1 chronic HCV patients.[14,15]

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References:

  1. Sulkowski, M S et al.Ribavirin dose modification in treatment-naïve and previously treated ppatients who received telaprevir combination treatment: no impact on sustained virologic response in phase 3 studies. Poster presented at the 47th Annual Meeting of the European Association of Study of the Liver (EASL)2012
  2. Copegus® Summary of Product Characteristics, updated 2012
  3. Jacobson, I et al. Telaprevir for Previously Untreated Hepatitis C Virus Infection. N Engl J Med. 2011;364:2405-16. (ADVANCE)
  4. Sherman, K et al. Response-Guided Telaprevir Combination Treatment for Hepatitis C Virus Infection. N Engl J Med. 2011;365:1014-24. (ILLUMINATE)
  5. Zeuzem,S et al. Telaprevir for Retreatment of HCV Infection. N Engl J Med. 2011;364:2417-28.(REALIZE)
  6. Incivo® Summary of Product Characteristics, updated 2011
  7. Cu
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