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INCIVO® (Telaprevir) SVR Rates Unaffected by Ribavirin Dose Reduction in Treatment Naïve and Previously Treated Patients With Genotype-1 Chronic HCV
Date:4/18/2012

LIZE study, 38% (98/259) had a ribavirin dose reduction during the overall treatment phase.[1] In all Phase 2 and 3 studies, anaemia occurred more commonly in patients on a telaprevir-based regimen and led to discontinuation of all study drugs in 2.8%.[6]

Additional telaprevir data to be presented at EASL include:

  • Analysis showing that telaprevir in combination with peginterferon alfa and ribavirin is cost-effective for both treatment-naïve and experienced patients, regardless of IL28B subtype, according to the threshold of £20,000-£30,000 per quality-adjusted life year (QALY)[7]

About INCIVO®

INCIVO® (telaprevir), in combination with peginterferon alfa and ribavirin, is indicated for the treatment of genotype-1 chronic HCV in adult patients with compensated liver disease (including cirrhosis) who are treatment naïve, and who have previously been treated with interferon alfa (pegylated or non pegylated) alone or in combination with ribavirin, including relapsers, partial responders and null responders.[6] INCIVO is a small molecule, selective inhibitor of the HCV serine protease, and a member of the new class of medicine for the treatment of genotype-1 chronic HCV, direct acting antivirals (DAAs).  Unlike previous treatments, DAAs act directly on viral enzymes and prevent the virus from replicating. INCIVO was approved by the European Commission on 19 September 2011.

Telaprevir was developed by Janssen-Virco BVBA, one of the Janssen Pharmaceutical Companies, in collaboration with Vertex and Mitsubishi Tanabe Pharma. Janssen has rights to commercialize telaprevir in Europe, South America, Australia, the Middle East and certain other countries. Vertex has rights to commercialize telaprevir in North America where it is bei
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SOURCE Janssen Pharmaceutica N.V
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