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INCIVO® (Telaprevir) SVR Rates Unaffected by Ribavirin Dose Reduction in Treatment Naïve and Previously Treated Patients With Genotype-1 Chronic HCV
Date:4/18/2012

BARCELONA, Spain, April 18, 2012 /PRNewswire/ --

-   Retrospective sub-analyses from ADVANCE, ILLUMINATE and REALIZE Phase 3 studies will be presented at European Association for the Study of the Liver (EASL) 2012 -

Janssen Pharmaceutica NV (Janssen) will present new data for INCIVO (telaprevir) from Phase 3 retrospective sub-analyses at the 47th annual meeting of the European Association for the Study of the Liver (EASL) in Barcelona.  The data shows that similar sustained virologic response (SVR) rates were achieved regardless of ribavirin dose reduction, including dose reduction to ≤ 600mg/day in a telaprevir-based treatment regimen for both treatment naïve and previously treated genotype-1 chronic HCV patients.[1]

The study abstract is currently published online (http://www.easl.eu) and full results will be presented on Saturday 21st April at 12:30pm CET.

The retrospective sub-analyses of the Phase 3 ADVANCE and ILLUMINATE trials evaluated the impact of ribavirin dose reduction on SVR rates in treatment-naïve genotype-1 chronic HCV patients who received treatment with telaprevir in combination with peginterferon alfa and ribavirin (T12PR) or peginterferon alfa and ribavirin alone (PR).[1] In the T12PR arms, SVR was achieved by 74% (291/395) of patients who received a dose reduction to ≤ 600mg and 75% (38/51) who received a ribavirin dose reduction to 800-1000mg/day, compared to 79% (346/439) of those who had no reduction in their ribavirin dose.[1]

The retrospective sub-analysis of the Phase 3 REALIZE trial evaluated the impact of ribavirin dose reduction on SVR rates of previously treated genotype-1 chronic HCV patients who received treatment with telaprevir in combination with peginterferon alfa and ribavirin (T12PR48) or peginterferon
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SOURCE Janssen Pharmaceutica N.V
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