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IDM Pharma Announces IDM-2101 Updated Phase 2 Results Show Treatment Well Tolerated With Positive Survival Trend in Lung Cancer Patients
Date:11/2/2007

- Patients on IDM-2101 showed an improvement in median survival vs.

parallel external controls -

IRVINE, Calif., Nov. 2 /PRNewswire-FirstCall/ -- IDM Pharma, Inc. (Nasdaq: IDMI) today announced updated results from the Phase 2 study of its investigational agent IDM-2101 which showed the vaccine was well tolerated, induced broadly specific cytotoxic T lymphocyte (CTL) responses, and showed a positive survival trend in patients with non-small cell lung cancer (NSCLC) who were vaccinated with IDM-2101, compared to a parallel external control group of non-vaccinated patients.

The data will be presented during an oral session on Sunday, November 4 at 8:45 a.m. EST at the International Society for Biological Therapy of Cancer (iSBTc) annual meeting in Boston.

"We are encouraged by the positive trend in overall survival we are seeing in patients who were treated with IDM-2101," said Minal Barve, M.D., practice director, Mary Crowley Cancer Research Center. "We believe that the survival trend, as well as the tolerability and robust immunological response data, warrant further examination to confirm the treatment benefits of IDM-2101 for patients with non-small cell lung cancer."

Trial Design and Results

The Phase 2 open label, non-randomized trial with one year follow-up for survival was designed to assess overall survival and vaccine immunogenicity in HLA-A2 positive patients with stage IIIb, IV or recurrent non-small cell lung cancer. Patients were required to have tumor volume less than 125 cm squared with no limits on prior chemotherapy. Sixty-eight patients were enrolled in the trial (sixty-three treated with one or more doses) with the last patient enrolled in Mar
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SOURCE IDM Pharma, Inc.
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