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IBM and EU Partners Create a Better Way to Fight AIDS Virus
Date:6/2/2009

om clinical practice. It is also the only system providing the global medical community with an estimate of activity for combination therapy, rather than for individual drugs.

Researchers behind the EU-funded EuResist project have developed new mathematical prediction models that not only take into account the patient's own history, but tap into the wealth of information that EuResist researchers have amassed. The recent expansion of the EuResist database to include information from more than 33,000 patients and 98,000 therapies, and 370,000 viral load measurements, makes it the world's biggest database centered on HIV resistance and clinical response information.

"EuResist has managed to create the largest clinically oriented antiretroviral drug resistance database in the world," explained Professor Maurizio Zazzi, EuResist Scientific Coordinator and Professor of Microbiology at the University of Siena School of Medicine." The ability to analyze clinical, laboratory and demographic data accumulated over the years significantly improves prediction of the right combination of drugs that works for the maximum amount of time." These innovations are being provided as a free tool that can help extend the lives of millions of people who are the victims of this disease.

The system's predictions are near 76% accurate, outperforming other commonly used HIV resistance prediction tools and also outperformed human experts in the field. To simulate real practice in HIV specialized care, the EVE (Engine versus Experts) study compared EuResist with 10 international experts confronted with 25 case histories, where all the clinical and virological information was available, EuResist's predictions outperformed nine out of ten human experts.

"The EuResist team feels both humbled and privileged by the opportunity to put good science and state-of-the-art technologies at the service of such an important and meaningful
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SOURCE IBM Corporation
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