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IBM Research and Institute of Bioengineering and Nanotechnology Discover Breakthrough for Breast Cancer Drug Delivery
Date:11/1/2013

a targeted location directly at the tumor site over weeks instead of days. Once the drug has been delivered, the hydrogel biodegrades naturally and passes through the body.

"Drawing from our experience in materials innovation for electronics technology, we are now applying these techniques to the quest for improved health," said Dr. James Hedrick, Advanced Organic Materials Scientist, IBM Research – Almaden. "This hydrogel can help deliver drugs over an extended period of time without causing a significant immune response, effectively sending its contents directly to the tumor without harming healthy surrounding cells."

In animal studies done by Singapore's IBN, testing demonstrated improved results when the antibody was paired and delivered with the hydrogel, even at low concentration, than on its own.

  • Tumor Size: Over the course of 28 days, the tumor shrank 77% when paired with the hydrogel via subcutaneous injection at the tumor site as opposed to 0% without it by intravenous injection. 
  • Treatment Frequency: When paired with the hydrogel and injected subcutaneously at a site far away from the tumor, the treatment frequency was reduced from 4 to 1 while maintaining a similar therapeutic effect. This is when compared to just the antibody solution formulation injected intravenously. 
  • Weight: The ability to target and deliver the drug directly at the tumor site allowed for only the infected cells to be eradicated, leaving healthy cells alone. This resulted in stable to moderate weight gain during the study instead of massive weight loss traditionally associated with cancer drug treatments.
  • Non-Toxic: Since the hydrogel is non-toxic, it demonstrated high biocompatibility as evidenced by no cellular inflammation with minimal immune system response while degrading naturally and passing through the body
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SOURCE IBM
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