Navigation Links
Hyperion Therapeutics Announces Results for Phase II Study in Urea Cycle Disorders
Date:3/30/2009

ere two SAEs related to hyperammonemia; both occurred during 100% BUPHENYL treatment. No SAEs occurred during 100% HPN-100 treatment. Ammonia values were ~30% lower on HPN-100 assessed as TNAUC over 24 hours [mean (SD) = 38.4 (19.6) versus 26.1 (10.3) umol/L), Cmax = 79.1 (40.1) versus 56.3 (27.9) umol/L, or the percentage of normal values: 58% vs. 72%]. Differences in ammonia values were not statistically significant.

"We are very pleased with the study results and our recent end of phase II meeting with the Food and Drug Administration," said Don Santel, Chief Executive Officer of Hyperion Therapeutics. "We are currently finalizing our phase III study protocol in consultation with the Agency and are eager to further explore the potential of HPN-100 for the treatment of urea cycle disorders."

About Urea Cycle Disorders

Urea cycle disorders are inherited, inborn errors of metabolism present in an estimated 1 in 10,000 births in the United States. Patients with urea cycle disorders are deficient in one of the key enzymes that comprise the urea cycle, the body's primary vehicle for removing ammonia, a potent neurotoxin, from the bloodstream. Onset may occur at any age depending on the severity of the disorder. Left untreated, urea cycle disorders can cause dangerously heightened levels of ammonia in the bloodstream (hyperammonemia) resulting in brain damage, coma, and/or death.

About HPN-100

HPN-100 is a pro-drug of phenylbutyrate and a pre-pro-drug of phenylacetic acid, the active moiety of BUPHENYL(R), the only therapy currently FDA-approved as adjunctive therapy for the chronic management of patients with the most prevalent urea cycle deficiencies including those related to carbamylphosphate synthetase, ornithine transcarbamylase and argininosuccinic acid synthetase. HPN-100, which is dosed orally in liquid form, provides an alternative pathway to the urea cycle for the disposal of waste nit
'/>"/>

SOURCE Hyperion Therapeutics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Hyperion Therapeutics Completes Enrollment in Phase 1/2 Clinical Trial in Patients With Urea Cycle Disorders
2. William R. Ringo Joins Hyperion Therapeutics, Inc. Board of Directors as Chairman
3. Hyperion Therapeutics Announces Enrollment of First Patient in Phase 1/2 Clinical Trial of GT4P in Patients With Urea Cycle Disorders
4. Amicus Therapeutics Announces Issuance of New Plicera(TM) Composition of Matter Patent
5. Vantia Therapeutics Pipeline Continues to Mature
6. Calixa Therapeutics Announces Positive Phase 1 Results for CXA-101, a Novel Intravenous Cephalosporin Antibiotic with Excellent Anti-Pseudomonal Activity
7. Oxygen Biotherapeutics, Inc. Receives Letter From FDA Outlining Path Forward to Resume Oxycyte Clinical Trials in TBI in U.S.A.
8. Alba Therapeutics Corporation Announces the Next Clinical Trial of Its Lead Compound, Larazotide Acetate and Promotions
9. InteKrin Therapeutics Announces Enrollment Completion of 360 Patient, 24 week Phase 2b Study
10. Ascenta Therapeutics Announces Positive Preliminary Results with AT-101 in Docetaxel Refractory Prostate Cancer
11. Amicus Therapeutics Suspends Enrollment for Phase 2 Clinical Trial of AT2220 for Pompe Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/5dh22x/urinary_catheters ) ... Market (Indwelling or Foley Catheters, Intermittent Catheters and Male ... Share, Growth, Trends and Forecast 2014 - 2020" ... present, the global market for urinary catheters is experiencing ...
(Date:1/23/2015)... , Jan. 23, 2015  MedScope ( www.medscope.org ), ... nominated for a 2015 Connected World magazine ... Response System (mPERS), that can be used anywhere, anytime. ... partner.  In nominating MedScope, Landon ...
(Date:1/23/2015)...  Pete Rose, baseball,s all-time hits leader, is the new spokesperson ... Ducere Pharma has announced. "Pete,s a Hall of ... him on board with Myoflex," said Ducere Pharma Chief Executive ... who is known across all generations. The passion and intensity ...
Breaking Medicine Technology:Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3MedScope Nominated by RacoWireless for Prestigious 2015 Connected World Magazine Connected World Award 2Pete Rose bets on Myoflex to relieve aches and pains 2
(Date:1/23/2015)... 23, 2015 Hastings and Hastings, a law ... a record number of legal representation client review requests for ... been a steady rise in the number of slip and ... home throughout the Valley. With that said, a large number ... by an experienced law firm. Hastings and Hastings is a ...
(Date:1/22/2015)... 23, 2015 The U.S. Pharmacopeial Convention ... Director of Clinical Pharmacy Services at North Carolina State’s ... of the 2015 Beal Award for Distinguished Volunteer Service—the ... relied on the contributions of volunteer experts to direct ...
(Date:1/22/2015)... 23, 2015 LunaDress, with its top dressmaking ... industry. Now, the business is showing its latest designs of ... , According to the company’s CEO, all the fresh new ... with big discounts, up to 80% off. All the clothes ...
(Date:1/22/2015)... Woodloch Pines, an all-inclusive family resort located ... the number one best large hotel for families in the ... their annual Travelers’ Choice Awards. , TripAdvisor represents the ... home to millions of unbiased and honest traveler reviews. The ...
(Date:1/22/2015)... Padre Murphy's and Owner Tom Boyle in Glendale, AZ ... Alliance (PPHA). The PPHA's passion for others' well-being and ... greats, treated for obstructive sleep apnea (OSA) has propelled them ... in the valley. The most recent plans for an event ...
Breaking Medicine News(10 mins):Health News:Hastings and Hastings Reports a Record Number of Client Review Requests for Slip and Fall Accidents in 2014 2Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 2Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 3Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 4Health News:LunaDress Shows The Latest Styles Of Wedding Dresses In 2015 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3
... its human organ donation programme in a bid to ... ,Health and Child Welfare Deputy Minister Edwin Muguti ... Because of its international scrutiny, Zimbabwe will craft strong ... Ziana paper reported. ,Currently, patients requiring ...
... woman in Orissa suspected of having contracted AIDS was allegedly ... ,Sabita Behera, 30, a resident of Keutunga village in ... the in-laws suspected she was an AIDS patient, police officer ... incident took place Friday night but came to light only ...
... push ahead with a new risk-based meat inspection system ... groups. // ,Federal meat inspectors will be ... in 30 locations starting in April, said the United ... Safey, Dr Richard A Raymond in a news conference ...
... key signaling protein in the brain during infancy could ... //According to findings published today in the journal Nature, ... serotonin just after birth exhibit abnormal anxiety as adults. ... mice genetically engineered to lack the receptor for serotonin, ...
... approved by the UAE Ministry of Health (MOH) against ... //prequalification status by the World Health Organization (WHO). It ... has received such clearance. ,The WHO prequalification endorses ... to fulfill tender specifications. This allows UN agencies, such ...
... is a strong genetic predictor of colorectal cancer, many ... screening. //According to a recent study in The American ... improved if physicians provided stronger encouragement and more complete ... ,“We studied families with a history of familial ...
Cached Medicine News:Health News:US Government Pushes Ahead With New Meat Inspection System 2Health News:US Government Pushes Ahead With New Meat Inspection System 3Health News:Mouse Study Suggests Anxiety Disorders Take Root in Infancy 2Health News:WHO Awards Prequalification Status to the First UAE Approved Vaccine 2
... The Featured Products ... at Mediflex and are ... modular in regular or ... come equipped with insulation, ...
... Featured Products are kept ... and are offered as ... regular or extra long ... with insulation, flush ports, ...
... Laparoscopic Instruments incorporate a layered design unique ... and monitored to prevent stray electrosurgical burns ... by insulation failure or capacitive coupling; a ... built into all AEM Instruments provides a ...
... Featured Products are kept ... and are offered as ... regular or extra long ... with insulation, flush ports, ...
Medicine Products: