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Human Vaccines & Immunotherapeutics Special Focus Highlights a Paradigm Shift in Cancer Vaccine Development
Date:8/27/2012

FREDERICK, Md., Aug. 27, 2012 /PRNewswire/ -- Vaccinogen, Inc. today announced Dr. Michael G. Hanna, Jr., Vaccinogen CEO and co-founder, has served as guest-editor and contributor for the Human Vaccines & Immunotherapeutics Special Focus on cancer vaccines and immunotherapeutics, one of the most comprehensive peer-reviewed discussions published on the field. The Special Focus highlights nearly two decades of research and clinical development programs and, for the first time, identifies tumor heterogeneity among the factors in the success or failure of cancer immunotherapies. The Special Focus also includes direct commentary on the technology platforms for products, clinical trial design issues, and manufacturing hurdles that factor into cancer vaccine development. Dr. Hanna contributed to an introductory overview of the cancer vaccine field, authored a paper on Vaccinogen's lead product OncoVAX®, and provided the summary titled "Cancer vaccines: Are we there yet?"

"There is a new paradigm in patient-specific immunotherapy using cancer vaccines. For decades, researchers developed cancer vaccines using off the shelf presumptive antigen(s) based on a false premise that cancer cells are alike, or homogeneous," said Dr. Hanna. "The vast amount of second generation DNA sequencing data generated over the past few years has clearly demonstrated that tumors are not homogenous. Instead there is heterogeneity in and among tumors of the same classification and pathological stage. These facts indicate that the best immunotherapeutic benefits will be achieved using patient specific therapies.  Vaccinogen's Phase III cancer vaccine for Stage II colon cancer, called OncoVAX, uses this validated approach with the patient's own live tumor cells as the source of the vaccine."

Ronald Ellis, Ph.D, Editor-in-Chief of Human Vaccines & Immunotherapeutics, said, "One of the central themes attributing to the success and failure of cancer vacci
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SOURCE Vaccinogen, Inc.
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