Human Genome Sciences Reports Substantial Progress Toward Commercialization and Announces 2009 Goals at JPMorgan Healthcare ...(of death worldwide and new approaches ar...),Health

Date:1/12/2009

of death worldwide and new approaches are needed to help reduce this burden to society. GSK is initiating the large STABILITY trial with darapladib as part of a Phase 3 program to determine if this novel medication could improve people's lives by reducing the risk of cardiovascular events." GSK also indicated that it plans to initiate another large event-driven trial with darapladib in late 2009 in a post-ACS (acute coronary syndrome) patient population.

MID- AND EARLY-STAGE PIPELINE

Syncria(R): GSK Update on Phase 3 Development Expected in the First Quarter

GSK is developing Syncria (albiglutide) as a treatment for type 2 diabetes mellitus, and has completed a number of clinical studies of Syncria, including a randomized Phase 2b dose-ranging trial of Syncria in patients with type 2 diabetes, which included a comparator arm of patients receiving Byetta (exenatide). HGS expects an update from GSK in the first quarter of 2009 regarding Phase 3 development of Syncria.

Syncria is a novel long-acting form of GLP-1 (glucagon-like peptide 1) created by HGS using its proprietary albumin-fusion technology, and licensed to GSK in 2004. Syncria is generated from the genetic fusion of human albumin and GLP-1, a peptide hormone that acts throughout the body to help maintain normal blood-sugar levels and to control appetite. HGS is entitled to fees and milestone payments, some of which have already been received, that could amount to as much as $183 million, in addition to single-digit royalties on worldwide sales if Syncria is commercialized.

Oncology Portfolio: A Key Driver of Future Growth

HGS is investing strategically to expand and advance its oncology portfolio around its leading expertise in the apoptosis, or programmed cell death, pathway. HGS-ETR1 (mapatumumab) is the most advanced of any product in development that targets the TRAIL apopt
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SOURCE Human Genome Sciences, Inc. Copyright©2009 PR Newswire. All rights reserved

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