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Human Genome Sciences Reports Progress With Late-Stage Products and New Initiatives
Date:5/28/2008

imminent in a Phase 1 clinical trial of HGS1029 in patients with advanced solid tumors. Preclinical studies of HGS1029 in combination with the Company's TRAIL receptor antibodies demonstrated synergistic activity against a number of cancer types. HGS1029 has also shown significant anti-tumor activity alone and in combination with other agents in a broad range of cancers. HGS plans to develop its TRAIL receptor antibodies and IAP inhibitors in combination with one another and in combination with other therapeutic agents.

HGS reacquired the rights to its TRAIL receptor antibodies from GSK in April 2008 in return for a reduction in royalties due to HGS if Syncria(R) (albiglutide) is commercialized. The fees and milestone payments due to HGS under the original Syncria agreement, some of which have already been received, could amount to as much as $183 million and remain unchanged in the amended agreement.

HGS views the oncology portfolio as a key driver of future growth beyond the launch of the Company's late-stage products. Reacquiring the rights to HGS-ETR1 and HGS-ETR2 (lexatumumab) gives HGS the opportunity to drive and advance this important program more aggressively by enabling the exploration of new alliances with a more optimal structure that could bring development expertise and resources, commercial leadership, near-term milestone payments and cost-sharing. HGS is also capable financially and organizationally of taking the TRAIL receptor antibodies forward on its own, thus retaining 100% of the value.

Key milestones of advancement for the HGS oncology portfolio:

-- Potential new alliance(s) for TRAIL receptor antibodies.

-- Initiation of HGS1029 Phase 1 trial in solid tumors imminent.

-- Initiation of HGS-ETR1 randomized trial in hepatocellular cancer.

-- Data expected from HGS-ETR1 Phase 2 trial in multiple myeloma in the

third quarter of 2008.

-- Data expected from HGS-ETR1 Phase 2 trial in n
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SOURCE Human Genome Sciences, Inc.
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