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Human Genome Sciences Reports Positive Long-Term Data for LymphoStat-B in Patients With Active Systemic Lupus Erythematosus
Date:6/12/2008

- Phase 2 data demonstrate sustained improvement in disease activity

through three years of LymphoStat-B (belimumab) therapy - - No increase in adverse events, malignancies, infections or laboratory

abnormalities over time -

ROCKVILLE, Md., June 12 /PRNewswire-FirstCall/ -- Human Genome Sciences, Inc. (Nasdaq: HGSI) today announced the presentation of results from a long- term Phase 2 continuation trial showing that LymphoStat-B(R) (belimumab) was associated with sustained improvement in disease activity across multiple clinical measures, decreased frequency of disease flares, potential steroid- sparing activity, and was generally well tolerated through three years on treatment in combination with standard of care in patients with serologically active systemic lupus erythematosus (SLE). The results are the subject of a number of oral and poster presentations today in Paris at the 2008 Congress of the European League Against Rheumatism (EULAR).

(Logo: http://www.newscom.com/cgi-bin/prnh/20080416/HGSLOGO )

"Based on the results presented at EULAR 2008, the clinical benefit observed for belimumab at Week 52 of this Phase 2 study appears to be durable through three years," said Richard Furie, M.D., Chief, Division of Rheumatology and Allergy-Clinical Immunology, North Shore Long Island Jewish Health System, Lake Success, NY, and Associate Professor of Medicine, New York University School of Medicine. "We observe that patients who crossed over from placebo to belimumab after Week 52 have also shown improvement across multiple clinical measures. The durability of clinical effect and the favorable safety p
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SOURCE Human Genome Sciences, Inc.
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