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Human Genome Sciences Reports Positive Data from Long-Term Treatment with LymphoStat-B(R) in Patients with Active Systemic Lupus Erythematosus
Date:11/9/2007

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(4-pt or greater reduction).

-- A sustained improvement in the percentage of serologically active

patients who experienced no new BILAG A organ flare and no more than

one new BILAG B organ flare (92% at Week 52; 94% at Week 128).

-- A sustained improvement in the percentage of serologically active

patients showing no worsening in SLE disease activity, as measured by

the Physician's Global Assessment (<.03-pt worsening - 90% at Week 52

and 91% at Week 128).

-- A decrease over time in the overall frequency of SLE disease flares,

and in the frequency of severe disease flares, in patients who remained

on LymphoStat-B through 2.5 years, as measured by the SELENA SLEDAI SLE

Flare Index.

-- Sustained response to LymphoStat-B therapy was independent of the type

of autoantibody at baseline.

A separate poster presentation reported that LymphoStat-B also promoted progressive normalization of autoantibody, immunoglobulin and complement levels over 2.5 years of therapy in SLE patients (Stohl et al), including:

-- Stable reductions in immunoglobulins, with no increase in infections or

infectious events over time.

-- Normalization of IgG in patients with elevated IgG at baseline; from

45% to 57% of patients with hypergammaglobulinemia at baseline

normalized at Weeks 52-128.

-- An increase in C3 and C4 complement among patients with low complement

at baseline.

-- Reversion of autoantibody levels from positive to negative (anti-dsDNA,

anti-RNP, anti-Smith).

About LymphoStat-B

LymphoStat-B is a human monoclonal antibody that specifically recognizes and inhibits the biological activity of B-lymphocyte stimulator, or BLyS(R). BLyS is a naturally occurring protein discovered by HGS that is required for the development of B-lymphocyte cells into mature plasma B cells. Plasma B cells produce a
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SOURCE Human Genome Sciences, Inc.
Copyright©2007 PR Newswire.
All rights reserved

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