Navigation Links
Human Genome Sciences Reports Positive Data from Long-Term Treatment with LymphoStat-B(R) in Patients with Active Systemic Lupus Erythematosus
Date:11/9/2007

>

(4-pt or greater reduction).

-- A sustained improvement in the percentage of serologically active

patients who experienced no new BILAG A organ flare and no more than

one new BILAG B organ flare (92% at Week 52; 94% at Week 128).

-- A sustained improvement in the percentage of serologically active

patients showing no worsening in SLE disease activity, as measured by

the Physician's Global Assessment (<.03-pt worsening - 90% at Week 52

and 91% at Week 128).

-- A decrease over time in the overall frequency of SLE disease flares,

and in the frequency of severe disease flares, in patients who remained

on LymphoStat-B through 2.5 years, as measured by the SELENA SLEDAI SLE

Flare Index.

-- Sustained response to LymphoStat-B therapy was independent of the type

of autoantibody at baseline.

A separate poster presentation reported that LymphoStat-B also promoted progressive normalization of autoantibody, immunoglobulin and complement levels over 2.5 years of therapy in SLE patients (Stohl et al), including:

-- Stable reductions in immunoglobulins, with no increase in infections or

infectious events over time.

-- Normalization of IgG in patients with elevated IgG at baseline; from

45% to 57% of patients with hypergammaglobulinemia at baseline

normalized at Weeks 52-128.

-- An increase in C3 and C4 complement among patients with low complement

at baseline.

-- Reversion of autoantibody levels from positive to negative (anti-dsDNA,

anti-RNP, anti-Smith).

About LymphoStat-B

LymphoStat-B is a human monoclonal antibody that specifically recognizes and inhibits the biological activity of B-lymphocyte stimulator, or BLyS(R). BLyS is a naturally occurring protein discovered by HGS that is required for the development of B-lymphocyte cells into mature plasma B cells. Plasma B cells produce a
'/>"/>

SOURCE Human Genome Sciences, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Video: New Research Discovers Independent Brain Networks Control Human Walking
2. Lpath Demonstrates Strong Safety Profile of Lead Drug Candidate, Sphingomab(TM), in Non-Human Primates
3. Enrollment Begins on Human PK Study for Medidur(TM) FA
4. Human Genome Sciences Completes Enrollment of First Phase 3 Albuferon(R) Trial Ahead of Schedule
5. Study Confirms Limited Human-To-Human Spread of Avian-Flu Virus in Indonesia in 2006
6. Lpath Demonstrates Preclinical Efficacy of Lpathomab(TM) and Initiates Humanization Process
7. Peregrine Researchers Report Data Showing Bavituximabs Potential to Shrink Human Prostate Tumors in Model of Relapsed Disease
8. Dr. Roger Kenneth Hershline PhD MD, CEO of Global Humanceuticals, Inc. Donates New HIV Drug
9. Study Shows Plasma-Derived Human Thrombin Equivalent to Bovine Thrombin in Achieving Hemostasis in Surgery
10. Tengion Launches Second Phase 2 Clinical Trial of Regenerated Human Organ
11. Flexible Medical Systems Raises $1.2M Seed Investment for Initial Human Trials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/6/2015)... 2015  EnteroMedics Inc. (NASDAQ: ETRM ), a ... to treat obesity, metabolic diseases, and other gastrointestinal disorders, ... of its previously announced underwritten public offering of 40,229,886 ... per unit. Canaccord Genuity was acting ... acting as co-manager for the offering. The ...
(Date:7/6/2015)... -- EndoChoice Holdings, Inc. (NYSE:  GI) announced today that it ... Thursday, August 6, 2015 before the market open. ... Thursday, August 6, 2015 at 9:00 a.m. ET to ... for domestic callers and (412) 317-5415 for international callers.  ... available on the investor relations section of the Company,s ...
(Date:7/6/2015)... HAYWARD, Calif. , July 6, 2015  Impax ... the Company will release its second quarter 2015 financial ... open of the U.S. financial markets. The Company will ... investment community at 8:30 a.m., Eastern Time on August ... webcast will be accessible through the Investor Relations section ...
Breaking Medicine Technology:EnteroMedics Inc. Announces Termination of Public Offering of Common Stock and Warrants 2EndoChoice to Report Second Quarter 2015 Financial Results on August 6, 2015 2Impax to Report Second Quarter 2015 Results on August 10, 2015 2
... Fairleigh Dickinson University and Medco Health Solutions, Inc. ... of $5 million to support the opening of a ... (Logo:   http://photos.prnewswire.com/prnh/20100609/MEDCOLOGO ) The Medco ... become New Jersey,s first pharmacy school affiliated with an ...
... Pharma Services, a privately owned Canadian pharmaceutical services ... company has entered into a Manufacturing Services Agreement ... in Washington DC, dedicated to the development of ... degenerative disorders. Dalton Pharma Services will ...
Cached Medicine Technology:Fairleigh Dickinson University Announces Partnership with Medco Health Solutions, Inc. for New School of Pharmacy 2Fairleigh Dickinson University Announces Partnership with Medco Health Solutions, Inc. for New School of Pharmacy 3Dalton and Oncovir Enter Into a Manufacturing Services Agreement 2Dalton and Oncovir Enter Into a Manufacturing Services Agreement 3Dalton and Oncovir Enter Into a Manufacturing Services Agreement 4Dalton and Oncovir Enter Into a Manufacturing Services Agreement 5Dalton and Oncovir Enter Into a Manufacturing Services Agreement 6
(Date:7/6/2015)... ... 06, 2015 , ... PristineHydro ( http://www.pristinewaterfilters.com ) has developed ... impurities; it also properly mineralizes the water with electrolyte salts.  Common tap water ... contaminants are a byproduct of how the water is treated chemically.  In response, ...
(Date:7/6/2015)... ... July 06, 2015 , ... “ TapGlance ” was featured on NewsWatch ... coolest applications on the market for iOS, Android, and Windows. Joe Toohey, the host ... this interior design app helps users visualize what rooms will look like before they ...
(Date:7/6/2015)... (PRWEB) , ... July 06, 2015 , ... University ... revising national guidelines for thyroid cancer testing to reflect newly available tests that better ... to use and how to interpret thyroid cancer tests is published in the July ...
(Date:7/6/2015)... ... July 06, 2015 , ... In order to recognize and ... Society for Sports Medicine ( AOSSM ) will present ten research awards and ... a leader in orthopaedic sports medicine, AOSSM annually provides more than $350,000 to ...
(Date:7/6/2015)... ... July 06, 2015 , ... On June 22, 2015, Fox News in a report titled “ Female Hair Loss ... turn age 35 a quarter of all women in the U.S. will suffer from thinning ... stigmatized and rarely discussed. One woman, a former beauty queen, who was interviewed for the ...
Breaking Medicine News(10 mins):Health News:Pristine Water Filters.com Offers The 1st Water Revival System That Re-Mineralizes Drinking Water and Eliminates All Impurities and Chemicals 2Health News:Create a Space with TapGlance, a Revolutionary Interior Design Application 2Health News:Pitt Scientists Lead Consensus Guidelines for Thyroid Cancer Molecular Tests 2Health News:Pitt Scientists Lead Consensus Guidelines for Thyroid Cancer Molecular Tests 3Health News:Pitt Scientists Lead Consensus Guidelines for Thyroid Cancer Molecular Tests 4Health News:Pitt Scientists Lead Consensus Guidelines for Thyroid Cancer Molecular Tests 5Health News:American Orthopaedic Society for Sports Medicine (AOSSM) Presents Prestigious Research Awards at Annual Meeting 2Health News:American Orthopaedic Society for Sports Medicine (AOSSM) Presents Prestigious Research Awards at Annual Meeting 3Health News:American Orthopaedic Society for Sports Medicine (AOSSM) Presents Prestigious Research Awards at Annual Meeting 4Health News:American Orthopaedic Society for Sports Medicine (AOSSM) Presents Prestigious Research Awards at Annual Meeting 5Health News:American Orthopaedic Society for Sports Medicine (AOSSM) Presents Prestigious Research Awards at Annual Meeting 6Health News:The Stigma of Female Hair Loss and Hair Restoration Solutions 2
... and treated in many cases, say US doctors. In peripheral ... become blocked with the same kind of fatty deposits - ... of treating it is very simple - keep walking. While ... the ability to walk with ease. Positive effects are seen ...
... Nearly half of people with Parkinson's disease are using one ... as vitamins, message or acupuncture. Researchers at Johns Hopkins University ... than 200 people with Parkinson's disease. Forty per cent use ... cent use five or more different ones. There's no link ...
... Bubonic plague, the bacterium blamed for the Black Death ... biological weapon, has had its entire genome sequenced. The ... and picking up new genes from other microbes. ,That ... emerge. More ominously, it suggests that enhanced strains might ...
... with a skin condition called contact dermatitis may benefit from ... tomatoes, according to the results of a small study.// Individuals ... they come in contact with substances they are allergic to. ... the skin, and many people may not realize foods can ...
... New research confirms that the main ingredient in the -- ... loss when used long term. The younger you are when ... bone-related problems later in life. // ... our bone mass is constantly breaking down and re-building, usually ...
... Suppression of testosterone levels in men with testicular ... disease, warn US researchers.,A research team from North ... levels go down, a high rise in levels ... disease – occurs. They suggest that this phenomenon ...
Cached Medicine News:Health News:Sequencing of the Plague 2
... Template is designed for use with ... for prostate brachytherapy. Please be sure ... match the graphics on the Reusable ... protruding from lower surface which fits ...
Table mount stabilizer system...
The compact PT stepper is lightweight, user-friendly, and versatile. The perfect solution for a busy brachytherapy facility....
... source consists of a welded titanium capsule ... four resin beads. The capsule body ... serve as x-ray markers to identify the ... are supplied non-sterile when shipped and must ...
Medicine Products: