Navigation Links
Human Genome Sciences Reports Initial Results of Randomized Phase 2 Trial of HGS-ETR1 in Combination With Bortezomib in Advanced Multiple Myeloma
Date:9/2/2008

ong patients in the treatment group receiving the combination of bortezomib and mapatumumab at 20 mg/kg, vs. no complete responses in the group receiving bortezomib alone.

-- Clinical responses were observed in 51.4% (18/35) of patients in the treatment group receiving bortezomib alone (0 complete and 18 partial). The response rate observed for bortezomib in the current study compares with a response rate identified in the FDA-approved bortezomib label of approximately 38%.

-- Clinical responses were observed in 50.0% (18/36) of patients in the treatment group receiving the combination of bortezomib and mapatumumab at 20 mg/kg (3 complete and 15 partial).

-- Clinical responses were observed in 30.3% (10/33) of patients in the treatment group receiving the combination of bortezomib and mapatumumab at 10 mg/kg (0 complete and 10 partial).

-- Stable disease was observed in approximately a third of the patients on study and was comparable across all treatment groups.

The multiple myeloma study is ongoing, and 58 patients in this study have not yet experienced disease progression and continue to be treated and/or followed.

About the HGS-ETR1 Proof-of-Concept Trials

The HGS-ETR1 proof-of-concept phase currently includes three randomized trials to evaluate its potential in combination with chemotherapy for the treatment of specific cancers:

-- Patients in the multiple myeloma trial will continue on treatment until the progression of disease, and HGS expects to have final data available from this study in 2009, including data on the important secondary endpoint of progression-free survival.

-- In August 2008, the Company completed the enrollment and initial dosing of patients in a randomized Phase 2 trial of HGS-ETR1 (10 mg/kg or 30 mg/kg) in combination with paclitaxel and carboplatin as first-line therapy in patients with advanced non-small cell lung cancer (NSCLC); initial data from the study are anticipated
'/>"/>

SOURCE Human Genome Sciences, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Video: New Research Discovers Independent Brain Networks Control Human Walking
2. Lpath Demonstrates Strong Safety Profile of Lead Drug Candidate, Sphingomab(TM), in Non-Human Primates
3. Enrollment Begins on Human PK Study for Medidur(TM) FA
4. Human Genome Sciences Completes Enrollment of First Phase 3 Albuferon(R) Trial Ahead of Schedule
5. Study Confirms Limited Human-To-Human Spread of Avian-Flu Virus in Indonesia in 2006
6. Lpath Demonstrates Preclinical Efficacy of Lpathomab(TM) and Initiates Humanization Process
7. Peregrine Researchers Report Data Showing Bavituximabs Potential to Shrink Human Prostate Tumors in Model of Relapsed Disease
8. Dr. Roger Kenneth Hershline PhD MD, CEO of Global Humanceuticals, Inc. Donates New HIV Drug
9. Study Shows Plasma-Derived Human Thrombin Equivalent to Bovine Thrombin in Achieving Hemostasis in Surgery
10. Tengion Launches Second Phase 2 Clinical Trial of Regenerated Human Organ
11. Flexible Medical Systems Raises $1.2M Seed Investment for Initial Human Trials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... , January 23, 2015 Heptares Therapeutics, ... delighted to announce that the Malcolm Campbell Memorial ... (Vice President of Chemistry), Fiona Marshall (Chief ... Executive Officer and co-founder) for the seminal contributions to GPCR ...
(Date:1/22/2015)... 22, 2015  BiOptix is pleased to announce the appointment ... of Chemistry and Biochemistry. Scott joins the company after previous ... Amgen throughout the course of his nearly 20 year ... is a nationally recognized thought leader in the biosensor ...
(Date:1/22/2015)... - Pivotal Therapeutics Inc. (OTCQX:PVTTF; CSE:PVO), ("Pivotal" or the "Company"), a ... cardiovascular disease and overall health is pleased to provide you ... its outlook for 2015 from the CEO, Mr. Eugene ... would like to take this opportunity to share with you ...
Breaking Medicine Technology:Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 2Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 3Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 4BiOptix Expands Leadership Team with the Appointment of Dr. Scott Klakamp as Vice President of Chemistry and Biochemistry 2Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7
... BOSTON, Dec. 29, 2011  Solos Endoscopy, Inc. (OTCPK: SNDY) ... continued growth in 2012 through the development and sales ... treatment and management of medical conditions. In 2011, Solos ... approximately $300,000 in debt for the Company. The signed ...
... Dec. 29, 2011 Janssen Research & Development, LLC (JRD) ... Application (sNDA) to the U.S. Food and Drug Administration (FDA) ... an oral anticoagulant, to reduce the risk of (thrombotic) cardiovascular ... The filing is supported by data from the pivotal Phase ...
Cached Medicine Technology:Solos Endoscopy, Inc. is Primed for Growth in 2012 2Solos Endoscopy, Inc. is Primed for Growth in 2012 3Janssen Research & Development Submits Application to U.S. FDA for XARELTO® (rivaroxaban) to Reduce Secondary Cardiovascular Events in Patients with Acute Coronary Syndrome 2Janssen Research & Development Submits Application to U.S. FDA for XARELTO® (rivaroxaban) to Reduce Secondary Cardiovascular Events in Patients with Acute Coronary Syndrome 3Janssen Research & Development Submits Application to U.S. FDA for XARELTO® (rivaroxaban) to Reduce Secondary Cardiovascular Events in Patients with Acute Coronary Syndrome 4Janssen Research & Development Submits Application to U.S. FDA for XARELTO® (rivaroxaban) to Reduce Secondary Cardiovascular Events in Patients with Acute Coronary Syndrome 5Janssen Research & Development Submits Application to U.S. FDA for XARELTO® (rivaroxaban) to Reduce Secondary Cardiovascular Events in Patients with Acute Coronary Syndrome 6Janssen Research & Development Submits Application to U.S. FDA for XARELTO® (rivaroxaban) to Reduce Secondary Cardiovascular Events in Patients with Acute Coronary Syndrome 7Janssen Research & Development Submits Application to U.S. FDA for XARELTO® (rivaroxaban) to Reduce Secondary Cardiovascular Events in Patients with Acute Coronary Syndrome 8Janssen Research & Development Submits Application to U.S. FDA for XARELTO® (rivaroxaban) to Reduce Secondary Cardiovascular Events in Patients with Acute Coronary Syndrome 9Janssen Research & Development Submits Application to U.S. FDA for XARELTO® (rivaroxaban) to Reduce Secondary Cardiovascular Events in Patients with Acute Coronary Syndrome 10Janssen Research & Development Submits Application to U.S. FDA for XARELTO® (rivaroxaban) to Reduce Secondary Cardiovascular Events in Patients with Acute Coronary Syndrome 11
(Date:1/22/2015)... Carinsurancesavings.biz has released a new blog post ... insurance . , Purchasing an accidental death and dismemberment ... This type of rider provides benefits if the insured dies ... a lesser form of life insurance. , AD&D is ...
(Date:1/22/2015)... 22, 2015 Yesterday, Senator Holly ... and Kristin Olsen (R-Modesto) were honored by the ... advancing biotechnology, biomedical science, medical device and pharmaceutical ... received the “2014 Life Sciences Champion” award from ...
(Date:1/22/2015)... Colorado (PRWEB) January 22, 2015 Four years since ... Queen – which coincided with the marriage of Avasa & Matthew ... THE ROAD, which is scheduled for release through White Swan Records ... message that there is a sacred path available to all of ...
(Date:1/22/2015)... January 22, 2015 As interest in the ... care gains momentum worldwide, Rev. Eric J. Hall , ... Network (HCCN), will be the keynote speaker on January ... Israel’s public health system. , The conference, “Hope and Resilience: ...
(Date:1/22/2015)... released a new blog post explaining the importance of keeping a ... of an auto insurance policy . , Clients who driver ... their vehicle insurance policies. The safety a vehicle offers from its ... of this, drivers should always carry a first aid kit in ...
Breaking Medicine News(10 mins):Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3Health News:Driving Safe And Other Factors That Make Auto Insurance Affordable! 2
... HRH Princess Haya Al Hussein of Jordan yesterday called for ... a medical conference hosted by the Aswan Heart Centre. , ... years in paediatric cardiology could not have happened without adequate ... to be done as we acquire more experience and develop ...
... ... After months of training and preparation, today the SUMMIT ON THE ... (19,340-ft) mountain - Mt. Kilimanjaro. The reason? To raise awareness about ... clean water programs in the developing world. , To view the ...
... , LOS ANGELES, Jan. 8 ... statement regarding Governor Schwarzenegger,s recommended cuts to the state,s ... budget today. , "The Governor,s proposed 2010/2011 budget ... with disabilities, and those who provide them with vital ...
... ATLANTA, Jan. 8 /PRNewswire/ - It,s important for health care ... of the Health Information Technology for Economic and Clinical Health ... , Part of the 2009 economic stimulus package, the HITECH ... encourage the use of electronic health record (EHR) systems among ...
... , , NEW YORK, Jan. 8 ... it will broadcast The Dean,s List: A Decade in Medicine ... the last ten years hosted by Dr. Andrew Brotman, Vice Dean ... XM,s 24/7 health and medical channel. , (Logo: http://www.newscom.com/cgi-bin/prnh/20080819/NYTU044LOGO ...
... , , ARLINGTON, Va., Jan. 8 ... waves through, virtually the entire field of health care law. ... BNA,s Health Law Reporter advisory board, in a ... http://www.newscom.com/cgi-bin/prnh/20090105/56509LOGO ) , The majority of survey respondents applauded ...
Cached Medicine News:Health News:HRh Princess Haya Highlights Need for Medical Research 2Health News:PUR Water Filtration and P&G's Children's Safe Drinking Water Program Take Jessica Biel, Kenna and Other Cultural Influencers to Meet Those Affected by the Clean Drinking Water Crisis Before Embarking on SUMMIT ON THE SUMMIT: Kilimanjaro 2Health News:PUR Water Filtration and P&G's Children's Safe Drinking Water Program Take Jessica Biel, Kenna and Other Cultural Influencers to Meet Those Affected by the Clean Drinking Water Crisis Before Embarking on SUMMIT ON THE SUMMIT: Kilimanjaro 3Health News:PUR Water Filtration and P&G's Children's Safe Drinking Water Program Take Jessica Biel, Kenna and Other Cultural Influencers to Meet Those Affected by the Clean Drinking Water Crisis Before Embarking on SUMMIT ON THE SUMMIT: Kilimanjaro 4Health News:PUR Water Filtration and P&G's Children's Safe Drinking Water Program Take Jessica Biel, Kenna and Other Cultural Influencers to Meet Those Affected by the Clean Drinking Water Crisis Before Embarking on SUMMIT ON THE SUMMIT: Kilimanjaro 5Health News:PUR Water Filtration and P&G's Children's Safe Drinking Water Program Take Jessica Biel, Kenna and Other Cultural Influencers to Meet Those Affected by the Clean Drinking Water Crisis Before Embarking on SUMMIT ON THE SUMMIT: Kilimanjaro 6Health News:Response to Governor Schwarzenegger's Proposed FY10-11 Budget and Recommended Cuts to State's Homecare Program 2Health News:Elekta to Host Complimentary HITECH Act Webinar 2Health News:Biggest Medical Breakthroughs and Milestones of the Last Decade Broadcast on SIRIUS XM's 'Doctor Radio' Channel 2Health News:Biggest Medical Breakthroughs and Milestones of the Last Decade Broadcast on SIRIUS XM's 'Doctor Radio' Channel 3Health News:Biggest Medical Breakthroughs and Milestones of the Last Decade Broadcast on SIRIUS XM's 'Doctor Radio' Channel 4Health News:Restructuring, Consolidation in Health Care Make Reform Top Health Law Issue for 2010 2
... For use with metered dose inhalers., ... aerosolized medication from MDI canisters. Its versatile ... a ventilator circuit, in conjunction with an ... routine, oral inhalation. ACE may also be ...
... as well as humidification, try Flo-Mist™., ... volume, continuous medication nebulizer (CMN), engineered to ... 200 ml reservoir and jet flow design ... nebulized medication delivery at 25 ml/hr. Particles ...
... Volume Medication Mouthpiece 7FT O 2 Tubing ... jet design for fast treatment times , ... tighter distribution (higher percentage of respirable particles) than ... brand Misty Max 10™ disposable nebulizers deliver fast ...
... in Anesthesia and Respiratory Products, ,Westmed ... devices for Anesthesia and Respiratory professionals. Our ... that enhance the clinician's ability to deliver ... to the bottom line. , ,Our ...
Medicine Products: