Navigation Links
Human Genome Sciences Reports Initial Results of Randomized Phase 2 Trial of HGS-ETR1 in Combination With Bortezomib in Advanced Multiple Myeloma
Date:9/2/2008

ong patients in the treatment group receiving the combination of bortezomib and mapatumumab at 20 mg/kg, vs. no complete responses in the group receiving bortezomib alone.

-- Clinical responses were observed in 51.4% (18/35) of patients in the treatment group receiving bortezomib alone (0 complete and 18 partial). The response rate observed for bortezomib in the current study compares with a response rate identified in the FDA-approved bortezomib label of approximately 38%.

-- Clinical responses were observed in 50.0% (18/36) of patients in the treatment group receiving the combination of bortezomib and mapatumumab at 20 mg/kg (3 complete and 15 partial).

-- Clinical responses were observed in 30.3% (10/33) of patients in the treatment group receiving the combination of bortezomib and mapatumumab at 10 mg/kg (0 complete and 10 partial).

-- Stable disease was observed in approximately a third of the patients on study and was comparable across all treatment groups.

The multiple myeloma study is ongoing, and 58 patients in this study have not yet experienced disease progression and continue to be treated and/or followed.

About the HGS-ETR1 Proof-of-Concept Trials

The HGS-ETR1 proof-of-concept phase currently includes three randomized trials to evaluate its potential in combination with chemotherapy for the treatment of specific cancers:

-- Patients in the multiple myeloma trial will continue on treatment until the progression of disease, and HGS expects to have final data available from this study in 2009, including data on the important secondary endpoint of progression-free survival.

-- In August 2008, the Company completed the enrollment and initial dosing of patients in a randomized Phase 2 trial of HGS-ETR1 (10 mg/kg or 30 mg/kg) in combination with paclitaxel and carboplatin as first-line therapy in patients with advanced non-small cell lung cancer (NSCLC); initial data from the study are anticipated
'/>"/>

SOURCE Human Genome Sciences, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Video: New Research Discovers Independent Brain Networks Control Human Walking
2. Lpath Demonstrates Strong Safety Profile of Lead Drug Candidate, Sphingomab(TM), in Non-Human Primates
3. Enrollment Begins on Human PK Study for Medidur(TM) FA
4. Human Genome Sciences Completes Enrollment of First Phase 3 Albuferon(R) Trial Ahead of Schedule
5. Study Confirms Limited Human-To-Human Spread of Avian-Flu Virus in Indonesia in 2006
6. Lpath Demonstrates Preclinical Efficacy of Lpathomab(TM) and Initiates Humanization Process
7. Peregrine Researchers Report Data Showing Bavituximabs Potential to Shrink Human Prostate Tumors in Model of Relapsed Disease
8. Dr. Roger Kenneth Hershline PhD MD, CEO of Global Humanceuticals, Inc. Donates New HIV Drug
9. Study Shows Plasma-Derived Human Thrombin Equivalent to Bovine Thrombin in Achieving Hemostasis in Surgery
10. Tengion Launches Second Phase 2 Clinical Trial of Regenerated Human Organ
11. Flexible Medical Systems Raises $1.2M Seed Investment for Initial Human Trials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... Dec. 15, 2014  Stephen Squires, CEO and founder ... Materials Corp (OTCQB:QTMM), will be speaking at the ... (RCQM) on December 16th, 2014. The RCQM launch continues ... in attracting top faculty and students and by inviting ... research. "We have a long association ...
(Date:12/13/2014)... , Dec. 11, 2014 Research and Markets ... addition of the "Drug Injection Devices to ... http://photos.prnewswire.com/prnh/20130307/600769 As ... an expanding list of health conditions, drug developers ... simplify the administration process and increase the efficiency ...
(Date:12/13/2014)... 2014 Research and ... of the  "Global Capnography Market 2015-2019" ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,Capnography is the measurement ... gasses during the integral part of anesthesia ... about CO2 production, alveolar ventilation, and elimination ...
Breaking Medicine Technology:Quantum Materials CEO Stephen Squires to Speak at Rice Center for Quantum Materials Launch 2Quantum Materials CEO Stephen Squires to Speak at Rice Center for Quantum Materials Launch 3Drug Injection Devices to 2020 2Drug Injection Devices to 2020 3Drug Injection Devices to 2020 4Global Capnography Market 2015-2019: Key Vendors are Covidien, Masimo, Philips Healthcare, Smiths Medical and Welch Allyn 2Global Capnography Market 2015-2019: Key Vendors are Covidien, Masimo, Philips Healthcare, Smiths Medical and Welch Allyn 3
... 2011 The U.S. Food and Drug Administration today ... implement during 2011 to improve the most common path ... http://photos.prnewswire.com/prnh/20090824/FDALOGO ) Key actions include: ... innovative, lower-risk medical devices, Clarifying when clinical data ...
... Throughout the playoffs and championship game of Professional Football, ... play at winning TemporalScanner™ Temporal Artery Thermometers. Football fans ... announced on national radio broadcasts of pro football,s divisional ... win an Exergen TemporalScanner. The "Exergen ...
Cached Medicine Technology:FDA to Improve Most Common Review Path for Medical Devices 2Exergen 'Game Time Temperature' Contest Helps Football Fans Tackle Cold and Flu Season 2Exergen 'Game Time Temperature' Contest Helps Football Fans Tackle Cold and Flu Season 3
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... As clashes between,rebels and government troops have ... International Medical Corps (IMC) continues,delivering emergency assistance to ... safety of its staff., Tens of thousands ... of,Goma. International Medical Corps staff began relocating operations ...
... hazard, British researchers say , , THURSDAY, Oct. 30 (HealthDay ... touted for years, but heavy metal contamination found in ... health benefit into a hazard, British researchers report. , ... as Parkinson,s disease and may also increase oxidative stress, ...
... Ballot Argument, SACRAMENTO, Calif., Oct. 30 The ... by more than 300 leading California,pediatricians announcing their joint ... signed the Prop 8 ballot statement, Jane Anderson,MD, in ... issue., The pediatrician statement took issue with Dr. ...
... Election Day, researchers from Harvard School of Public Health and ... New England Journal of Medicine, find that seven ... the U.S. health care system. , The article, written by ... Analysis at the Harvard School of Public Health, Drew E. ...
... of Registered Voters in,September, As Well As Other Recent ... PARK, Calif., Oct. 30 With only a few,days ... Health and the Kaiser Family Foundation, writing for the ... that seven in ten,registered voters say major changes are ...
... Sensing,Systems, Inc. (Nasdaq: ISNS ), announced today its ... (Logo: http://www.newscom.com/cgi-bin/prnh/20050512/CGISSLOGO ), Net income for ... per fully diluted share) compared to $1.3 million ($0.34 ... Net income for the first nine,months of 2008 was ...
Cached Medicine News:Health News:International Medical Corps Continues Delivering Emergency Relief Amid Violence in Democratic Republic of Congo 2Health News:Heavy Metals Can Taint Wine 2Health News:Heavy Metals Can Taint Wine 3Health News:NO on Prop 8 Campaign Releases Statement by 300 California Pediatricians 2Health News:Pre-election surveys show deep concern about state of health care 2Health News:Results From Pre-Election Surveys Published in NEJM Show Deep Concerns About State of Health Care With McCain and Obama Supporters Differing Sharply on Directions for New Administration 2Health News:Results From Pre-Election Surveys Published in NEJM Show Deep Concerns About State of Health Care With McCain and Obama Supporters Differing Sharply on Directions for New Administration 3Health News:Results From Pre-Election Surveys Published in NEJM Show Deep Concerns About State of Health Care With McCain and Obama Supporters Differing Sharply on Directions for New Administration 4Health News:Image Sensing Systems Announces Third Quarter Financial Results 2Health News:Image Sensing Systems Announces Third Quarter Financial Results 3Health News:Image Sensing Systems Announces Third Quarter Financial Results 4Health News:Image Sensing Systems Announces Third Quarter Financial Results 5Health News:Image Sensing Systems Announces Third Quarter Financial Results 6Health News:Image Sensing Systems Announces Third Quarter Financial Results 7Health News:Image Sensing Systems Announces Third Quarter Financial Results 8Health News:Image Sensing Systems Announces Third Quarter Financial Results 9
Sheath Introducers with guidewires....
... Stent design, utilizing an advanced ... of stainless steel stents. This ... struts, for unparalleled flexibility plus ... Coronary Stent Systemwith thin struts ...
... Guiding Catheter provides support to enhance ... under adverse conditions. It gives you ... to your destination in cardiac interventions. ... variety of clinical situations and the ...
... Xtra, and Maximum ACT introducers represent ... specialty hemostasis introducers in the world. ... hemostasis introducers for use in interventional ... angioplasty, stenting, atherectomy, temporary pacing, endomyocardial ...
Medicine Products: