Navigation Links
Human Genome Sciences Reports Initial Results of Randomized Phase 2 Trial of HGS-ETR1 in Combination With Bortezomib in Advanced Multiple Myeloma
Date:9/2/2008

- First of three ongoing randomized chemotherapy combination trials to

evaluate HGS-ETR1 in the treatment of specific cancers -

ROCKVILLE, Md., Sept. 2 /PRNewswire-FirstCall/ -- Human Genome Sciences, Inc. (Nasdaq: HGSI) today reported initial topline results from an ongoing randomized Phase 2 clinical trial of its TRAIL receptor antibody HGS-ETR1 (mapatumumab) in combination with bortezomib (Velcade) in patients with advanced multiple myeloma. The initial data from the multiple myeloma study show that HGS-ETR1 was well tolerated and suggest that disease response was comparable for this combination vs. bortezomib alone.

(Logo: http://www.newscom.com/cgi-bin/prnh/20080416/HGSLOGO )

"We continue to be excited about HGS-ETR1 and our TRAIL receptor antibody program," said David C. Stump, M.D., Executive Vice President, Research and Development, HGS. "The TRAIL-mediated apoptosis pathway is an important area of cancer research, and agonistic antibodies to this target offer great promise. HGS-ETR1 is the most advanced of any product in development that targets this pathway, with three randomized chemotherapy combination trials currently ongoing to evaluate its potential for the treatment of specific cancers. We look forward to maturing results from all three trials. Taken together, these results will inform our decision on whether to advance HGS- ETR1 to Phase 3 development."

Key Findings

The trial in advanced multiple myeloma is a randomized, multi-center, open-label Phase 2 study to evaluate the efficacy and safety of HGS-ETR1 (mapatumumab) in combination with bortezomib in these patients. 104 patients are being treat
'/>"/>

SOURCE Human Genome Sciences, Inc.
Copyright©2008 PR Newswire.
All rights reserved

1

GOOD

Page: 1 2 3 4 5 6

Related medicine technology :

1. Video: New Research Discovers Independent Brain Networks Control Human Walking
2. Lpath Demonstrates Strong Safety Profile of Lead Drug Candidate, Sphingomab(TM), in Non-Human Primates
3. Enrollment Begins on Human PK Study for Medidur(TM) FA
4. Human Genome Sciences Completes Enrollment of First Phase 3 Albuferon(R) Trial Ahead of Schedule
5. Study Confirms Limited Human-To-Human Spread of Avian-Flu Virus in Indonesia in 2006
6. Lpath Demonstrates Preclinical Efficacy of Lpathomab(TM) and Initiates Humanization Process
7. Peregrine Researchers Report Data Showing Bavituximabs Potential to Shrink Human Prostate Tumors in Model of Relapsed Disease
8. Dr. Roger Kenneth Hershline PhD MD, CEO of Global Humanceuticals, Inc. Donates New HIV Drug
9. Study Shows Plasma-Derived Human Thrombin Equivalent to Bovine Thrombin in Achieving Hemostasis in Surgery
10. Tengion Launches Second Phase 2 Clinical Trial of Regenerated Human Organ
11. Flexible Medical Systems Raises $1.2M Seed Investment for Initial Human Trials

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/9/2009)...a., Nov. 9 TessArae® LLC, a g...ications, announces the launch of new integrated p...ons that underlie human hereditary diseases. The ...based resequencing with novel nucleotide sequence ...es screening for all targeted mutations in multipl...
(Date:11/9/2009)...D, N.Y., Nov. 9 /PRNewswire/ -- On Sept. 11, 200...other rescue workers came together to save as many...ighter Brian McCauley was one of those 9/11 first ...e. ,, Only in his late 30s, McCauley was diagno...and extensive chemotherapy treatments, leaving him...
(Date:11/9/2009)...., Nov. 9 Women,s sexual health co... name to Viveve as it prepares for a 2010 launch o...ets. ,, "Viveve is a name that we believe captu...xual health," said Kerry Pope, Viveve,s president ...urpose of helping women restore their sense of ful...
Breaking Medicine Technology:TessArae Delivers Lower Cost Option to Genetic Testing Market 2The SCOOTER Store Surprises 9/11 First Responder & Merrick Firefighter With Power Chair 2The SCOOTER Store Surprises 9/11 First Responder & Merrick Firefighter With Power Chair 3Women's Sexual Health Company Changes Name in Preparation for Market Entry 2Lots of Schoolkids Squint to See Chalkboard 53528 1Operation Rescue Announces Keep It Closed Campaign 53523 1Operation Rescue Announces Keep It Closed Campaign 53523 2Radiation exposure during interventional procedures a concern for some developing countries 53520 1
(Date:11/9/2009)...of care increases with longer doctor visits, resea... News) -- Family doctors are now taking more time ...ften and improving the quality of visits, a new st...their primary care physicians during office visits...d overall they seemed to receive better care," sai...
(Date:11/9/2009)... Course, to be Offered in April 2...lkit , Cambridge, MA (Voc...sicians for Human Rights (PHR) first inspected a s...an , he realized he would need a team of experts t...ng the site properly was a key first step in secur...
(Date:11/9/2009)...BANON, Tenn., Nov. 9 Health Connec...nced it will host their inaugural Hospital O.R. an... at the Marriott Renaissance Hotel in Nashville, T...re than 100 hospital operating room directors and ...alth systems in the country. Some of the confirmed...
(Date:11/9/2009)...W YORK, Nov. 9 The award...its world television debut on the Sundance Channel...EST/PST. ,, Directed by Academy Award® no...s of children with type 1 diabetes amid the verdan... world,s poorest countries. The children are suppo...
(Date:11/9/2009)...SHINGTON, Nov. 9 Speak...raising provisions in the Affordable Health Care f...ccess to Medicaid and reduce Medicare Part D costs... the House on Saturday by a vote of 220 to 215: ,... health and quality of life for thousands of Ameri...
Breaking Medicine News(10 mins):Health News:Doctors Spending More Time Now With Patients 2Health News:Doctors Spending More Time Now With Patients 3Health News:Physicians for Human Rights Offers Training in Crime Scene Documentation 2Health News:Physicians for Human Rights Offers Training in Crime Scene Documentation 3Health News:Physicians for Human Rights Offers Training in Crime Scene Documentation 4Health News:Health Connect Partners Hosts Hospital O.R. & Surgery Center Conference 2Health News:Award-winning Diabetes Documentary to Make World TV Premiere on Sundance Channel on World Diabetes Day 2Health News:Award-winning Diabetes Documentary to Make World TV Premiere on Sundance Channel on World Diabetes Day 3Health News:Award-winning Diabetes Documentary to Make World TV Premiere on Sundance Channel on World Diabetes Day 4Health News:Award-winning Diabetes Documentary to Make World TV Premiere on Sundance Channel on World Diabetes Day 5Health News:Award-winning Diabetes Documentary to Make World TV Premiere on Sundance Channel on World Diabetes Day 6Health News:Pelosi Applauds Provisions in Health Bill to Improve Access to Care, Medications for People Living With HIV/AIDS 2
...ned immune systems should not eat raw// or underco...ns by Health Canada. “Eat veggies full of vita...ower and green beans help to keep us strong, energ... have been blamed for bringing on sickness and eve...
...rust, chronic stress and depression,// may be ass... measured in the blood, which in turn are related ...ccording to a report in the January 22 issue of Ar...r disease and death, according to background infor...
...adly, hundred of persons have been infected with H...stry of heath have ordered the recall of samples o...mune system deficiencies. The drug manufact...ry and drug watchdog, the State Food and Drug Admi...
...will help in the management of epilepsy. // Sc...w York carried out a study that showed that some p...s bound to occur. The findings were published in N...epsy who had at least one seizure in the last 12 m...
...he patients for publishing their views on hospital...w" the performance of their GPs or hospitals throu...ereby helping others to decide where to go for tre...ut doctors said the idea was "gimmicky". NHS r...
...ture system, which makes way for a better study of...ation of virus// (isolated from patient) in non-tr...lture of permissive viral strains in transformed c... appears in the February issue of The American Jou...
Other Medicine News:Health News:Raw (or) Undercooked Sprouts May Carry Harmful Bacteria 2Health News:Psychosocial Factors Associated With Higher Levels of Inflammatory Markers 2Health News:Drug Meant to Heal Turns ‘heel’ and Har 2Health News:When Epilepsy Patients Play Soothsayers 2Health News:A Breakthrough in the Study of Hepatitis C 2
MYO-VAD™ Cardiac Assist Device
LOGIQ Book XP
Rio™ Aspiration Catheter
VASOVIEW® HemoPro™ Endoscopic Vessel Harvesting System
Medicine Products: