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Human Genome Sciences Presents Results of Phase 2 Trial of Albuferon(R) in Chronic Hepatitis C Patients Who Failed To Respond To Previous Therapy
Date:11/5/2007

mcg and 1800 mcg. The most common adverse events were fatigue, headache, arthralgia (joint pain), myalgia (muscle pain), insomnia, nausea, cough, and pyrexia (fever). Discontinuation rates due to adverse events were: 4.2% for the 1200 mcg every four weeks group; 17.4% for the 900 mcg every two weeks group; 4.2% for the 1200 mcg every two weeks group; 9.1% for the 1500 mcg every two weeks group; and 18.2% for the 1800 mcg every two weeks group. Hematologic reductions stabilized by Week 8, were well managed with dose reductions, and returned to baseline following the completion of therapy.

"The results emerging from our Phase 2 program continue to support our belief that Albuferon could become an important therapeutic option for patients with chronic hepatitis C, including those that have failed prior therapy," said Mani Subramanian, M.D., Ph.D., Senior Director of Clinical Research, Infectious Diseases, HGS.

About Albuferon

Albuferon is a novel long-acting form of interferon alpha created by HGS using its proprietary albumin fusion technology. Albuferon results from the genetic fusion of human albumin and interferon alpha. Human albumin is the most prevalent naturally occurring blood protein in the human circulatory system, persisting in circulation in the body for more than 20 days. Research shows that genetic fusion of therapeutic proteins to human albumin decreases clearance and prolongs the half-life of the proteins. Recombinant interferon alpha is approved for the treatment of hepatitis C, hepatitis B and a number of cancers.

Albuferon is being developed by HGS and Novartis for the treatment of chronic hepatitis C under a worldwide co-development and commercialization agreement entered into in June 2006. HGS and Novartis will co-commercialize Albuferon in the United States and will share clinical development costs, U.S. commercialization costs and U.S. profits equally. Novartis will be responsible for commercialization in the rest of the
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SOURCE Human Genome Sciences, Inc.
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