Navigation Links
Human Genome Sciences Presents New Data Showing Anti-Tumor Activity And Safety Of Trail Receptor Antibodies In Combination With Chemotherapy
Date:10/24/2007

n more than 20 patients, a number of whom remained on treatment for more than five months before progression of disease."

About the Preclinical Results in Cholangiocarcinoma

Results were also presented from preclinical studies that evaluated the ability of HGS-ETR1 and HGS-ETR2 to kill cancer cells and inhibit tumor growth as single agents and in combination with chemotherapy agents: cisplatin, gemcitabine or 5-fluorouracil. Efficacy was measured using cell toxicity assays in cholangiocarcinoma cell lines (in vitro) and in a xenograft cholangiocarcinoma tumor model (in vivo).

The in vitro study showed that HGS-ETR1 or HGS-ETR2 combined with either a pre-treatment or a co-treatment chemotherapy regimen induced additive or synergistic cytotoxicity. Co-treatment with the triplet combination of cisplatin, gemcitabine and either HGS-ETR1 or HGS-ETR2 was more effective than either single agent alone in all cell lines, with most triplet combinations inducing greater than 90 percent cell toxicity. In a xenograft model of cholangiocarcinoma, the combination of HGS-ETR1, cisplatin and gemcitabine significantly inhibited tumor growth, including tumor regression observed at a dose of 8 mg/kg of cisplatin.

About the HGS TRAIL Receptor Antibodies

HGS-ETR1 and HGS-ETR2 are agonistic human monoclonal antibodies that directly induce cancer-cell death by specifically binding to and activating the proteins known as TRAIL receptors 1 and 2, respectively. Using genomic techniques, HGS originally identified the TRAIL receptor-1 and TRAIL receptor- 2 proteins. The HGS-ETR1 and HGS-ETR2 antibodies were generated by HGS through collaboration with Cambridge Antibody Technology. HGS is developing HGS-ETR1 and HGS-ETR2 as potential treatments for a broad range of cancers.

GlaxoSmithKline (GSK) has exercised its option under a June 1996 agreement to develop and commercialize HGS-ETR1 jointly with HGS. Under the terms of the agreement, GSK and HGS will share e
'/>"/>

SOURCE Human Genome Sciences, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Testing for Human Papillomavirus
2. Bio-Matrix Scientifics Dr. ONeill Sees University of Pittsburghs Published Study on Culture Blood-Forming Stem Cells from Human Fat Tissue as Supporting Near Term Benefits of Banking Adipose (Fat) Derived Stem Cells
3. Phase II Results Show Once-Daily Dosing of Human GLP-1 Analog Liraglutide, Brings Patients to A1c Target
4. Apollos human proteins boost stem cell research
5. Advanced Cell Technology Develops First Human Embryonic Stem Cell Line without Destroying an Embryo
6. Modigene Announces Successful Completion of Pharmacokinetic & Pharmacodynamic Pre-Clinical Experiments for Proprietary Long-Acting Human Growth Hormone, Long-acting Interferon Beta and Long-acting Erythropoietin
7. Second Successful Quigley QR-443 Study Suggests Method of Action Relevant to Broad Range of Chronic Inflammatory Diseases - Human Study to Follow -
8. Research Documents Scalable Production, Survival Following Engraftment and Positive Impact on Cardiac Function in Infarcted Rats for Gerons Human Embryonic Stem Cell-Based Therapeutic for Heart Failure
9. Human Genome Sciences Reports That a Phase 2 Study of LymphoStat-B Showed Significant Reductions in Disease Activity in Patients with Active Systemic Lupus Erythematosus
10. NCI Researchers Discover Genes That Are Turned on at High Levels in Tumor-associated Blood Vessels of Mice and Humans
11. Research Indicates Gerons Human Embryonic Stem Cell-Based Therapeutic for Spinal Cord Injury Evades Direct Attack by the Human Immune System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/5hkm2f/medical_oxygen ... Oxygen Systems - Global Strategic Business Report" report ... worldwide markets for Medical Oxygen Systems in US$ Thousands ... Oxygen Cylinders & Regulators, and Oxygen Conserving Devices. The ... Canada , Japan , ...
(Date:4/17/2015)... 2015 Today, the Pharmaceutical Research and ... 12 biopharmaceutical companies as "We Work For Health ... and community service. Established in 2009, ... created by the biopharmaceutical industry to honor employees ... but have also shown an outstanding commitment to ...
(Date:4/17/2015)... , Apr. 16, 2015 Research and ... the addition of the "The Corporate Reputation ... - Global Edition " report to their ... a Patient Perspective, is now in its fourth ... results; published early 2015). For each annual Corporate ...
Breaking Medicine Technology:Medical Oxygen Systems - 2015 Global Strategic Business Report Featuring Leading Players, Caire, Invacare & Philips Respironics 2PhRMA Applauds 2015 We Work For Health Champion Award Winners 2PhRMA Applauds 2015 We Work For Health Champion Award Winners 3The Corporate Reputation of Pharma - The Global Patient Perspective in 2014 2
... EF Johnson Technologies, Inc. (Nasdaq: EFJI ), a ... results for the quarter ended September 30, 2009. Revenues ... was $1.6 million, or $(0.06) per diluted share, for the ... pleased with our orders and contract awards, the third quarter ...
... Inc. (NYSE: ZMH ; SIX: ZMH) announced today that ... unsecured notes in an underwritten public offering consisting of $500.0 ... 5.75% notes due 2039. The 10-year notes were priced to ... 30-year notes were priced at 135 basis points above their ...
Cached Medicine Technology:EF Johnson Technologies Announces Third Quarter Results 2EF Johnson Technologies Announces Third Quarter Results 3EF Johnson Technologies Announces Third Quarter Results 4EF Johnson Technologies Announces Third Quarter Results 5EF Johnson Technologies Announces Third Quarter Results 6EF Johnson Technologies Announces Third Quarter Results 7EF Johnson Technologies Announces Third Quarter Results 8Zimmer Holdings, Inc. Agrees to Sell $1 Billion of Senior Notes 2
(Date:4/19/2015)... 19, 2015 Autocarinsurancecheap.com has released a ... can offer financial protection for vulnerable family members. ... the insured dies or is disabled in an accident. ... commonly bought with an auto insurance plan. However, AD&D ... similar to a life insurance policy. The newly blog ...
(Date:4/19/2015)... (PRWEB) April 19, 2015 Broccoli sprout ... tolerable in a small group of healthy human volunteers, ... partner with UPMC CancerCenter , announced today at ... Annual Meeting in Philadelphia. , The promising results ... which will recruit participants at high risk for head ...
(Date:4/19/2015)... April 19, 2015 Lowcostcarinsuranceprice.com has ... of pills can get drivers arrested for DUI. The ... auto insurance premiums . , Some pills ... to driver properly. Drivers who are under medication should ... effects of certain pills can be considered driving under ...
(Date:4/19/2015)... 2015 Insurancecarsinsurance.com has released a new ... explaining how bad weather can affect auto insurance ... big impact on auto insurance premiums. In some Northern ... prices are higher than in other parts. The newly ... during the next several months and what impact, if ...
(Date:4/19/2015)... WASHINGTON, DC (PRWEB) April 19, 2015 ... again teaming up with PROSHRED Security (“PROSHRED”) to host ... are invited to shred their personal documents in order ... about cancer prevention. , The June 6th event is ... from 8am – 2pm local time. The time will ...
Breaking Medicine News(10 mins):Health News:Accidental Death and Dismemberment Insurance Can Provide Financial Security! 2Health News:Preventing Cancer with Broccoli Sprout Extract 2Health News:Preventing Cancer with Broccoli Sprout Extract 3Health News:Driving On Medication - Possible Effects On Auto Insurance Prices 2Health News:Bad Weather Can Cause Accidents and Affect Auto Insurance Prices! 2Health News:2015 Annual Nationwide "Shred Cancer" Shredding Event 2
... , RALEIGH, N.C., Nov. 16 Blue Water Spa, a Raleigh ... Raleigh with an anniversary party and Raleigh food drive. Guests who ... One lucky winner will receive a $10,000 spa gift certificate for ... of NC will be on hand Wed. November 18 and Saturday ...
... SINGAPORE, Nov. 16 /PRNewswire-Asia/ -- Retail ... steadily in the first half of 2009 with,total consumption peaking ... major Contact Lens manufacturers. Positive sales,data showing a growth of ... an economic recovery that is being led by consumers spending. ...
... every household has some sort of a first aid kit filled ... plan ahead for dental emergencies? , According to a recent ... products, although one in six Americans had a dental emergency during ... the problem. , "You keep medical supplies on hand for ...
... ... it says there is no solidity or separation, as commonly understood, between any physical ... religion, economics; and create world peace, eternal life and time travel. , ... (PRWEB) November 16, 2009 -- This is intended ...
... ... impairments caused by Alzheimer,s disease, Traumatic Brain Injury, ADD, Schizophrenia and more. , ... (PRWEB) November 16, 2009 ... rehab tools for a variety of cognitive disorders at the American Medical Informatics ...
... ... Science’s “Best of What’s New” in 2009 for their HyGreen™ hand washing system. ... Sarasota, FL ... Science’s “Best of What’s New” in 2009 for their HyGreen™ hand washing system. Xhale, ...
Cached Medicine News:Health News:Raleigh Day Spa, Blue Water Spa, Raffles Off $10,000 in Day Spa Packages for Contributing to Raleigh Food Drive 2Health News:GfK Asia Reports: Malaysian Contact Lens Market Sees Strong Recovery in Second Half of 2009 2Health News:GfK Asia Reports: Malaysian Contact Lens Market Sees Strong Recovery in Second Half of 2009 3Health News:Be Prepared for a Dental Emergency During the Holidays 2Health News:New View Of Reality (In Printed Book Form) That Combines Einstein And Quantum Mechanics, And Fills The World With Miracles 2Health News:New View Of Reality (In Printed Book Form) That Combines Einstein And Quantum Mechanics, And Fills The World With Miracles 3Health News:HAPPYneuron Launches Beta Program for Innovative Cognitive Rehab Tools at AMIA Conference in San Francisco 2Health News:HAPPYneuron Launches Beta Program for Innovative Cognitive Rehab Tools at AMIA Conference in San Francisco 3Health News:Xhale Recognized in Popular Science's "Best of What's New" with hand from ROBRADY design 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: