Navigation Links
Human Genome Sciences Presents New Data Showing Anti-Tumor Activity And Safety Of Trail Receptor Antibodies In Combination With Chemotherapy
Date:10/24/2007

n more than 20 patients, a number of whom remained on treatment for more than five months before progression of disease."

About the Preclinical Results in Cholangiocarcinoma

Results were also presented from preclinical studies that evaluated the ability of HGS-ETR1 and HGS-ETR2 to kill cancer cells and inhibit tumor growth as single agents and in combination with chemotherapy agents: cisplatin, gemcitabine or 5-fluorouracil. Efficacy was measured using cell toxicity assays in cholangiocarcinoma cell lines (in vitro) and in a xenograft cholangiocarcinoma tumor model (in vivo).

The in vitro study showed that HGS-ETR1 or HGS-ETR2 combined with either a pre-treatment or a co-treatment chemotherapy regimen induced additive or synergistic cytotoxicity. Co-treatment with the triplet combination of cisplatin, gemcitabine and either HGS-ETR1 or HGS-ETR2 was more effective than either single agent alone in all cell lines, with most triplet combinations inducing greater than 90 percent cell toxicity. In a xenograft model of cholangiocarcinoma, the combination of HGS-ETR1, cisplatin and gemcitabine significantly inhibited tumor growth, including tumor regression observed at a dose of 8 mg/kg of cisplatin.

About the HGS TRAIL Receptor Antibodies

HGS-ETR1 and HGS-ETR2 are agonistic human monoclonal antibodies that directly induce cancer-cell death by specifically binding to and activating the proteins known as TRAIL receptors 1 and 2, respectively. Using genomic techniques, HGS originally identified the TRAIL receptor-1 and TRAIL receptor- 2 proteins. The HGS-ETR1 and HGS-ETR2 antibodies were generated by HGS through collaboration with Cambridge Antibody Technology. HGS is developing HGS-ETR1 and HGS-ETR2 as potential treatments for a broad range of cancers.

GlaxoSmithKline (GSK) has exercised its option under a June 1996 agreement to develop and commercialize HGS-ETR1 jointly with HGS. Under the terms of the agreement, GSK and HGS will share e
'/>"/>

SOURCE Human Genome Sciences, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Testing for Human Papillomavirus
2. Bio-Matrix Scientifics Dr. ONeill Sees University of Pittsburghs Published Study on Culture Blood-Forming Stem Cells from Human Fat Tissue as Supporting Near Term Benefits of Banking Adipose (Fat) Derived Stem Cells
3. Phase II Results Show Once-Daily Dosing of Human GLP-1 Analog Liraglutide, Brings Patients to A1c Target
4. Apollos human proteins boost stem cell research
5. Advanced Cell Technology Develops First Human Embryonic Stem Cell Line without Destroying an Embryo
6. Modigene Announces Successful Completion of Pharmacokinetic & Pharmacodynamic Pre-Clinical Experiments for Proprietary Long-Acting Human Growth Hormone, Long-acting Interferon Beta and Long-acting Erythropoietin
7. Second Successful Quigley QR-443 Study Suggests Method of Action Relevant to Broad Range of Chronic Inflammatory Diseases - Human Study to Follow -
8. Research Documents Scalable Production, Survival Following Engraftment and Positive Impact on Cardiac Function in Infarcted Rats for Gerons Human Embryonic Stem Cell-Based Therapeutic for Heart Failure
9. Human Genome Sciences Reports That a Phase 2 Study of LymphoStat-B Showed Significant Reductions in Disease Activity in Patients with Active Systemic Lupus Erythematosus
10. NCI Researchers Discover Genes That Are Turned on at High Levels in Tumor-associated Blood Vessels of Mice and Humans
11. Research Indicates Gerons Human Embryonic Stem Cell-Based Therapeutic for Spinal Cord Injury Evades Direct Attack by the Human Immune System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... WHITEHOUSE STATION, N.J. , Sept. 19, 2014 Merck ... the United States and Canada , ... on Desafiando La Diabetes: Logra Tus Metas , an educational ... of their blood sugar -- a key treatment goal to help ... the United States are at a higher risk for ...
(Date:9/19/2014)... Five MinuteClinic walk-in medical clinics are opening inside select CVS/pharmacy stores ... opened in Memphis and Cordova ... in Springfield on September 24 and a ... open October 22.  MinuteClinic is the largest and fastest growing provider ... . The Memphis -area clinics join ...
(Date:9/19/2014)... Mass. , Sept. 19, 2014  Pressure ... today announced it has received and approved all ... HT48 instruments and has begun to manufacture the ... first instrument will be ready for shipment by ... built and released at a rate of about ...
Breaking Medicine Technology:Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 2Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 3Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 4Celebrity Chef Leticia Moreinos Schwartz Partners with Merck on Desafiando La Diabetes: Logra Tus Metas to Urge Hispanics With Type 2 Diabetes to Get to Their A1C Goal 5MinuteClinic Walk-in Medical Clinics Opening in Memphis 2MinuteClinic Walk-in Medical Clinics Opening in Memphis 3Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 2Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 3
... June 27 /CNW/ -,Aspreva Pharmaceuticals Corporation (NASDAQ: ASPV; ... a clinical trial,comparing CellCept (oral mycophenolate mofetil, MMF) ... of care, for,inducing treatment response in the induction ... rates were similar in both arms, the trial ...
... WIRE)--Jun 27, 2007 - PrimeCell(TM),Therapeutics LLC (http://www.primecelltherapeutics.com) ... pre-clinical,studies for a clinical trial to assess ... bone marrow stem cells into,spinal cord injury ... preliminary report at the 13th,Annual Meeting of ...
Cached Medicine Technology:Aspreva and Roche Announce Preliminary Results for Phase III Study,Evaluating CellCept in Lupus Nephritis 2Aspreva and Roche Announce Preliminary Results for Phase III Study,Evaluating CellCept in Lupus Nephritis 3Aspreva and Roche Announce Preliminary Results for Phase III Study,Evaluating CellCept in Lupus Nephritis 4Aspreva and Roche Announce Preliminary Results for Phase III Study,Evaluating CellCept in Lupus Nephritis 5Aspreva and Roche Announce Preliminary Results for Phase III Study,Evaluating CellCept in Lupus Nephritis 6Aspreva and Roche Announce Preliminary Results for Phase III Study,Evaluating CellCept in Lupus Nephritis 7Aspreva and Roche Announce Preliminary Results for Phase III Study,Evaluating CellCept in Lupus Nephritis 8Clinical Trial Suggests Bone Marrow Stem Cells Are Useful for,Spinal Cord Injury; PrimeCell Therapeutics Provided Pre-Clinical,Study 2
(Date:9/21/2014)... York, NY (PRWEB) September 21, 2014 ... designs, develops, implements and supports electronic medical records ... significantly benefited from federal healthcare legislation during the ... to do so during the five years to ... and Clinical Health Act established Medicare and Medicaid ...
(Date:9/21/2014)... 2014 Originally approved by the ... Flovent (fluticasone propionate) is a synthetic ICS therapy ... the maintenance treatment of asthma prophylactically in children ... formulations, Diskus and HFA, which received the FDA ... ingredient, fluticasone propionate, can bind to glucocorticoid receptors ...
(Date:9/21/2014)... September 21, 2014 More than ... been added over the past month to a ... serious cardiovascular injuries caused by the dialysis concentrate, ... updated on September 15th shows 2,089 cases filed ... District Court, District of Massachusetts. These claims were ...
(Date:9/21/2014)... 21, 2014 Developers and plugin specialist ... announced a new transition plugin entitled Transpack Vol. 3 ... high quality transitions that will add a level of ... CEO of Pixel Film Studios. “Blurring the line between ... game changer.” , Transpack Vol. 3 returns with over ...
(Date:9/21/2014)... Top10BestSEOHosting.com, a leading review website, has recently ... the most recommended hosting suppliers for the webmasters ... products. , “Don’t waste your time on ... great hosting companies to you,” the IT manager ... GreenGeeks are the most recommended suppliers for everyone. ...
Breaking Medicine News(10 mins):Health News:Electronic Medical Records Systems in the US Industry Market Research Report Now Available from IBISWorld 2Health News:Electronic Medical Records Systems in the US Industry Market Research Report Now Available from IBISWorld 3Health News:Electronic Medical Records Systems in the US Industry Market Research Report Now Available from IBISWorld 4Health News:Flovent Asthma Market Sales & SWOT Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 2Health News:Flovent Asthma Market Sales & SWOT Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 3Health News:Flovent Asthma Market Sales & SWOT Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 4Health News:Federal GranuFlo Litigation Adds Dozens of Cases Alleging Serious Cardiovascular Injuries, Bernstein Liebhard LLP Reports 2Health News:Federal GranuFlo Litigation Adds Dozens of Cases Alleging Serious Cardiovascular Injuries, Bernstein Liebhard LLP Reports 3Health News:Federal GranuFlo Litigation Adds Dozens of Cases Alleging Serious Cardiovascular Injuries, Bernstein Liebhard LLP Reports 4Health News:Pixel Film Studios Released Transpack Vol. 3 Plugin Exclusively for Final Cut Pro X 2Health News:Leading Review Website Top10BestSEOHosting.com Unveils The Best Hosting Suppliers In September 2
... step up health tourism investment along the lines of Kerala, ... // ,"Being a source of rare Himalayan herbs ... Lahe-Thapa, the Nepal Tourism Board's director of marketing and promotion, ... (in southern India), Thailand and Malaysia, we will be looking ...
... into overweight children than formula-fed babies, says a study. // ... US are overweight, according to government statistics. This accounts for ... years, reported an online edition of health magazine WebMD. ... studied 15,253 children between the ages of nine and 14 ...
... once again offered a valuable insight for one of the ... // Red wine has always hogged a fair share of ... brain. A recent study seems to suggest that Red wine ... looking for! ,The researchers, from Mount Sinai School ...
... Health Department has announced that it is adequately ... as well as // control measures, to counter ... Kerala, Thiruvananthapuram, Alappuzha, Ernakulum and Kozhikode have reported ... slackened response by the Health watch dogs, Ms. ...
... A Ukrainian has invented a condom that plays music ... Chausovsky developed the birth control device as a novelty, ... said. ,A miniature loudspeaker and motion sensor ... of musical tones during sex. ,The condom's ...
... into crosses, Y's and T's, Cornell researchers have created ... into any desired shape for biomedical applications. ,Hydrogels ... cross-linked to one another to create many small empty ... a sponge. If the spaces are filled with a ...
Cached Medicine News:Health News:Nepal Plans to Promote Health Tourism Based on Traditional Medicine 2Health News:Synthetic DNA Makes Better Hydrogels for Drug Delivery 2
... Heavy Duty is a pressure relief mattress overlay ... specifically to the BariKare® Bed., ,INDICATIONS , ... lbs., Large patients at risk or suffering from ... mattress that would benefit from a pressure relief ...
... bariatric bed system which helps provide comfort ... care setting, ,INDICATIONS: ,Patients weighing up ... 2) ,Healthcare frame accommodating one or two ... ,CONTRAINDICATION: ,Total weight in excess of ...
... The BariMaxx™ is a full-featured healthcare ... environment for the care and management of ... up to 1000 lbs. ,Large patients at ... weight in excess of 1000 lbs. (including ...
EC+ Extra Care Bariatric Bed...
Medicine Products: