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Human Genome Sciences Presents New Data Showing Anti-Tumor Activity And Safety Of Trail Receptor Antibodies In Combination With Chemotherapy
Date:10/24/2007

n more than 20 patients, a number of whom remained on treatment for more than five months before progression of disease."

About the Preclinical Results in Cholangiocarcinoma

Results were also presented from preclinical studies that evaluated the ability of HGS-ETR1 and HGS-ETR2 to kill cancer cells and inhibit tumor growth as single agents and in combination with chemotherapy agents: cisplatin, gemcitabine or 5-fluorouracil. Efficacy was measured using cell toxicity assays in cholangiocarcinoma cell lines (in vitro) and in a xenograft cholangiocarcinoma tumor model (in vivo).

The in vitro study showed that HGS-ETR1 or HGS-ETR2 combined with either a pre-treatment or a co-treatment chemotherapy regimen induced additive or synergistic cytotoxicity. Co-treatment with the triplet combination of cisplatin, gemcitabine and either HGS-ETR1 or HGS-ETR2 was more effective than either single agent alone in all cell lines, with most triplet combinations inducing greater than 90 percent cell toxicity. In a xenograft model of cholangiocarcinoma, the combination of HGS-ETR1, cisplatin and gemcitabine significantly inhibited tumor growth, including tumor regression observed at a dose of 8 mg/kg of cisplatin.

About the HGS TRAIL Receptor Antibodies

HGS-ETR1 and HGS-ETR2 are agonistic human monoclonal antibodies that directly induce cancer-cell death by specifically binding to and activating the proteins known as TRAIL receptors 1 and 2, respectively. Using genomic techniques, HGS originally identified the TRAIL receptor-1 and TRAIL receptor- 2 proteins. The HGS-ETR1 and HGS-ETR2 antibodies were generated by HGS through collaboration with Cambridge Antibody Technology. HGS is developing HGS-ETR1 and HGS-ETR2 as potential treatments for a broad range of cancers.

GlaxoSmithKline (GSK) has exercised its option under a June 1996 agreement to develop and commercialize HGS-ETR1 jointly with HGS. Under the terms of the agreement, GSK and HGS will share e
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SOURCE Human Genome Sciences, Inc.
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