Human Genome Sciences Presents New Data Showing Anti-Tumor Activity And Safety Of Trail Receptor Antibodies In Combination With Ch... (

HOME >> MEDICINE >> TECHNOLOGY

Human Genome Sciences Presents New Data Showing Anti-Tumor Activity And Safety Of Trail Receptor Antibodies In Combination With Chemotherapy

Date:10/24/2007

- Results of first reported clinical trial of any antibody to TRAIL receptor 2 in combination with chemotherapy, presented at AACR-NCI-EORTC

International Conference - - Preclinical study demonstrating synergy of TRAIL receptor antibodies with

chemotherapy highlighted by meeting organizers in press activities -

ROCKVILLE, Md., Oct. 24 /PRNewswire-FirstCall/ -- Human Genome Sciences, Inc. (Nasdaq: HGSI) today announced that HGS-ETR2 (lexatumumab) was safe and well tolerated in combination with four different standard chemotherapy regimens in a Phase 1b clinical trial in patients with a wide range of cancer types. Objective responses were reported for two patients, and stable disease was observed in 22 patients. The trial was the first reported human study of an antibody to TRAIL receptor 2 in combination with chemotherapy. The results were presented today at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in San Francisco.

(Logo: http://www.newscom.com/cgi-bin/prnh/20010612/HGSLOGO )

The company also presented preclinical data demonstrating that HGS-ETR1 (mapatumumab) and HGS-ETR2 in combination with chemotherapy synergistically enhanced anti-tumor activity in cholangiocarcinoma (cancer of the bile ducts). In a xenograft model of cholangiocarcinoma, the results demonstrated that HGS- ETR1 and either co-treatment or pre-treatment with cisplatin and gemcitabine were more effective than chemotherapy or HGS-ETR1 alone.

"The clinical and preclinical results presented today add to a growing body of data showing that our agonistic antibodies to TR
'/>"/>

SOURCE Human Genome Sciences, Inc.
Copyright©2007 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5
Related medicine technology :

1. Testing for Human Papillomavirus
2. Bio-Matrix Scientifics Dr. ONeill Sees University of Pittsburghs Published Study on Culture Blood-Forming Stem Cells from Human Fat Tissue as Supporting Near Term Benefits of Banking Adipose (Fat) Derived Stem Cells
3. Phase II Results Show Once-Daily Dosing of Human GLP-1 Analog Liraglutide, Brings Patients to A1c Target
4. Apollos human proteins boost stem cell research
5. Advanced Cell Technology Develops First Human Embryonic Stem Cell Line without Destroying an Embryo
6. Modigene Announces Successful Completion of Pharmacokinetic & Pharmacodynamic Pre-Clinical Experiments for Proprietary Long-Acting Human Growth Hormone, Long-acting Interferon Beta and Long-acting Erythropoietin
7. Second Successful Quigley QR-443 Study Suggests Method of Action Relevant to Broad Range of Chronic Inflammatory Diseases - Human Study to Follow -
8. Research Documents Scalable Production, Survival Following Engraftment and Positive Impact on Cardiac Function in Infarcted Rats for Gerons Human Embryonic Stem Cell-Based Therapeutic for Heart Failure
9. Human Genome Sciences Reports That a Phase 2 Study of LymphoStat-B Showed Significant Reductions in Disease Activity in Patients with Active Systemic Lupus Erythematosus
10. NCI Researchers Discover Genes That Are Turned on at High Levels in Tumor-associated Blood Vessels of Mice and Humans
11. Research Indicates Gerons Human Embryonic Stem Cell-Based Therapeutic for Spinal Cord Injury Evades Direct Attack by the Human Immune System

Post Your Comments:

(Date:5/23/2013)... May 23, 2013 More than half of ... benefit from chemotherapy and still have excellent outcomes. To ... one of the largest sources of online consumer information ... interactive Facebook page provide recently diagnosed women with information ... avoid chemotherapy. "We anticipate these innovative social ...

(Date:5/23/2013)... -- Texas, premier physician associations today announced the establishment of ... need to provide demonstrably better and more efficient patient ... "I am confident the Physician Services Organization for ... Stephen L. Brotherton , MD, president of the ... doctors are determined to make health care better and ...

(Date:5/23/2013)... -- Ameritox, the nation,s leader in pain medication monitoring, ... become part of its Urine Drug Monitoring (UDM) ... improve the clinical outcomes for injured workers. ... in the workers, compensation industry, has used UDM ... strategy for several years. By establishing a comprehensive ...

Breaking Medicine Technology:Agendia Launches Social Media Campaigns to Help Breast Cancer Patients with Chemotherapy Decisions 2 Agendia Launches Social Media Campaigns to Help Breast Cancer Patients with Chemotherapy Decisions 3 TMA Launches Physician Services Organization for Patient Care 2 TMA Launches Physician Services Organization for Patient Care 3 TMA Launches Physician Services Organization for Patient Care 4 Ameritox Joins with Progressive Medical in Urine Drug Monitoring Network to Help Improve Care of Injured Workers 2 Ameritox Joins with Progressive Medical in Urine Drug Monitoring Network to Help Improve Care of Injured Workers 3

[0] Agendia Launches Social Media Campaigns to Help Breast Cancer Patients with Chemotherapy Decisions [0] TMA Launches Physician Services Organization for Patient Care [0] Ameritox Joins with Progressive Medical in Urine Drug Monitoring Network to Help Improve Care of Injured Workers

... OmniComm Systems, Inc. (OTC Bulletin Board: OMCM ... announced that it will be hosting the autumn eClinical ... in Fort Lauderdale, Florida from November 03-05, 2010. The ... Life Science organizations. The informal ambiance provides support for ...

... Calif., Sept. 21 Bionovo, Inc. (Nasdaq: BNVI, BNVID), a ... in women,s health and oncology, today announced that Dr. Isaac ... at the JMP Securities Healthcare Conference at 4:00 p.m. ET ... at the New York Palace hotel in New York City. ...

Cached Medicine Technology:OmniComm Systems, Inc. Hosts Autumn 2010 eClinical Forum Meeting 2 OmniComm Systems, Inc. Hosts Autumn 2010 eClinical Forum Meeting 3 Bionovo to Present at the JMP Securities Healthcare Conference 2

OmniComm Systems, Inc. Hosts Autumn 2010 eClinical Forum Meeting Bionovo to Present at the JMP Securities Healthcare Conference

(Date:5/24/2013)... HealthDay Reporter , , FRIDAY, May 24 (HealthDay ... are remarkable. But it was a physical challenge in ... of her sport. "I was an 11-year-old girl ... scoliosis was diagnosed by my orthopedic surgeon," said Lewis, ... Research Society and the American Academy of Orthopaedic Surgeons ...

(Date:5/24/2013)... 24, 2013 ResortQuest Real Estate® is ... Dayna Feher team at the firm’s Bethany Beach location. ... resorts her home in 1975. Her real estate career ... all aspects of the real estate business - receptionist, ... 12 years, a licensed sales associate. , “I ...

(Date:5/24/2013)... 24, 2013 The Mirena IUD lawyers ... news that the FDA has received more than 59,229 complaints ... from the intrauterine birth control device known as the Mirena ... issues reported by the women “included ‘expulsion,’ where the IUD ... that occurring,” according to an ABC News article. “Abdominal pain ...

(Date:5/24/2013)... CHI-California Healthcare Institute today submitted ... congressional delegation, joined by over 40 biomedical companies, ... paid to the U.S. Food and Drug Administration ... cuts will not include user fees paid to ... Development and FDA Appropriations Bill. CHI is a ...

(Date:5/24/2013)... Started in 1982, AMTC’s SHINE event is ... marks AMTC’s 31st anniversary. SHINE is a ministry run by ... Lewis and her daughter, Carey Lewis Arban. , This summer’s ... and music professionals including the New York Film Academy, The ... are kings of Hollywood and Christian casting directors. They seek ...

Breaking Medicine News(10 mins):Health News:Top-Ranked Golfer Beats Scoliosis 2 Health News:Top-Ranked Golfer Beats Scoliosis 3 Health News:Tammy Mushrush Joins ResortQuest Real Estate® and the Dayna Feher Team 2 Health News:Sufferers of Alleged Mirena IUD Side Effects Lodge More Than 59,000 Complaints With FDA, Rottenstein Law Group LLP Notes 2 Health News:California Biomedical Industry Leaders Urge Congress to Take Action on FDA User Fees for FY2014 2 Health News:California Biomedical Industry Leaders Urge Congress to Take Action on FDA User Fees for FY2014 3 Health News:AMTC’s Summer SHINE Event Coming to Orlando’s Luxurious Gaylord Palms July 2-7, 2013 2

[0] Top-Ranked Golfer Beats Scoliosis [0] Tammy Mushrush Joins ResortQuest Real Estate® and the Dayna Feher Team [0] Sufferers of Alleged Mirena IUD Side Effects Lodge More Than 59,000 Complaints With FDA, Rottenstein Law Group LLP Notes [0] California Biomedical Industry Leaders Urge Congress to Take Action on FDA User Fees for FY2014 [0] AMTC’s Summer SHINE Event Coming to Orlando’s Luxurious Gaylord Palms July 2-7, 2013

... some states have cut breast cancer screening programs , TUESDAY, ... mammograms for women ages 40 to 49 has decreased since ... the U.S. Preventive Services Task Force, according to a new ... risk for breast cancer should start having mammograms every two ...

... at the Mayo Clinic campus in Florida have found ... lung cancers, is over-produced in pancreatic cancer and is ... genetically inhibiting PKC in laboratory animals led to a ... The discovery, reported in the March 1 issue of ...

... ... ... ... ...

... often think about hot flashes, hormone shifts and mood swings. ... of heart disease intensifies drastically around the time of natural menopause, ... This news may come as a surprise, but experts explain that ... that there are ways to lower your risk. ...

... ... at the Parallels Summit 2010 , ... Miami, FL (PRWEB) February 23, 2010 -- Worldwide cloud enablement leader, ... Parallels Summit 2010., , ,Highlighting excellence in the industry, the awards recognize the outstanding ...

... ... ... ... ...

Access to Mammograms Drops After Guidelines Change Mayo Clinic researchers find oncogene is important in pancreatic cancer growth and spread Monique da Silva Joins Ogilvy Public Relations Worldwide to Lead North America Healthcare Practice Changes during menopause increases risk of heart disease and stroke Winners are Grinners at the Inaugural Parallels Partner Awards Jiffy Lube(R) Well On Its Way to Raising Another $1 Million to Fight Heart Disease

Rhoton Curettes, titanium, length 191 mm, straight....

Castroviejo "HM" Micro Needle Holder with Tungsten-Carbide Inserts, with catch. Serrated....

Clinical micro clamps by Acland. Matte finish. It provides impressive security in use, both against slippage and against leakage due to controlled closing force and working grip surface....

Medicine Products:

Rhoton Curettes Micro Needle Holder Vascular Clamps ABB-11 Vascular Clamps B-1