Navigation Links
Human Genome Sciences Presents New Data Showing Anti-Tumor Activity And Safety Of Trail Receptor Antibodies In Combination With Chemotherapy
Date:10/24/2007

- Results of first reported clinical trial of any antibody to TRAIL receptor 2 in combination with chemotherapy, presented at AACR-NCI-EORTC

International Conference - - Preclinical study demonstrating synergy of TRAIL receptor antibodies with

chemotherapy highlighted by meeting organizers in press activities -

ROCKVILLE, Md., Oct. 24 /PRNewswire-FirstCall/ -- Human Genome Sciences, Inc. (Nasdaq: HGSI) today announced that HGS-ETR2 (lexatumumab) was safe and well tolerated in combination with four different standard chemotherapy regimens in a Phase 1b clinical trial in patients with a wide range of cancer types. Objective responses were reported for two patients, and stable disease was observed in 22 patients. The trial was the first reported human study of an antibody to TRAIL receptor 2 in combination with chemotherapy. The results were presented today at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in San Francisco.

(Logo: http://www.newscom.com/cgi-bin/prnh/20010612/HGSLOGO )

The company also presented preclinical data demonstrating that HGS-ETR1 (mapatumumab) and HGS-ETR2 in combination with chemotherapy synergistically enhanced anti-tumor activity in cholangiocarcinoma (cancer of the bile ducts). In a xenograft model of cholangiocarcinoma, the results demonstrated that HGS- ETR1 and either co-treatment or pre-treatment with cisplatin and gemcitabine were more effective than chemotherapy or HGS-ETR1 alone.

"The clinical and preclinical results presented today add to a growing body of data showing that our agonistic antibodies to TR
'/>"/>

SOURCE Human Genome Sciences, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Testing for Human Papillomavirus
2. Bio-Matrix Scientifics Dr. ONeill Sees University of Pittsburghs Published Study on Culture Blood-Forming Stem Cells from Human Fat Tissue as Supporting Near Term Benefits of Banking Adipose (Fat) Derived Stem Cells
3. Phase II Results Show Once-Daily Dosing of Human GLP-1 Analog Liraglutide, Brings Patients to A1c Target
4. Apollos human proteins boost stem cell research
5. Advanced Cell Technology Develops First Human Embryonic Stem Cell Line without Destroying an Embryo
6. Modigene Announces Successful Completion of Pharmacokinetic & Pharmacodynamic Pre-Clinical Experiments for Proprietary Long-Acting Human Growth Hormone, Long-acting Interferon Beta and Long-acting Erythropoietin
7. Second Successful Quigley QR-443 Study Suggests Method of Action Relevant to Broad Range of Chronic Inflammatory Diseases - Human Study to Follow -
8. Research Documents Scalable Production, Survival Following Engraftment and Positive Impact on Cardiac Function in Infarcted Rats for Gerons Human Embryonic Stem Cell-Based Therapeutic for Heart Failure
9. Human Genome Sciences Reports That a Phase 2 Study of LymphoStat-B Showed Significant Reductions in Disease Activity in Patients with Active Systemic Lupus Erythematosus
10. NCI Researchers Discover Genes That Are Turned on at High Levels in Tumor-associated Blood Vessels of Mice and Humans
11. Research Indicates Gerons Human Embryonic Stem Cell-Based Therapeutic for Spinal Cord Injury Evades Direct Attack by the Human Immune System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... 2014 Professional Compounding Centers of America ... awarding the three best scientific presentations at the ... . The Formulating Better Medicines for Children ... Athens, Greece , includes dozens of ... from which three winners will be selected by ...
(Date:8/21/2014)... PARK, Calif. , Aug. 21, 2014 ... in the emerging field of regenerative medicine, announced today ... Ricciardi to the Company,s newly expanded Board of Directors. ... comprises eight directors, three of whom are independent. ... of experience working with emerging growth companies. He is ...
(Date:8/20/2014)... , Aug. 20, 2014 The National ... the latest results achieved by the real-time, pseudoephedrine ... the National Precursor Log Exchange (NPLEx), automatically blocks ... track down meth offenders and make arrests. Data ... Kansas blocked the sale of ...
Breaking Medicine Technology:Professional Compounding Centers of America will award top poster-session winners at European Paediatric Formulation Initiative in Athens 2Asterias Biotherapeutics Appoints Two Independent Directors and Announces Completion of Series A Common Stock Distribution 2Asterias Biotherapeutics Appoints Two Independent Directors and Announces Completion of Series A Common Stock Distribution 3Asterias Biotherapeutics Appoints Two Independent Directors and Announces Completion of Series A Common Stock Distribution 4Kansas's Stop-Sale System Achieves Significant Results In Battle Against Meth 2
(Date:8/21/2014)... 21, 2014 (HealthDay News) -- Black mothers are less ... here,s one possible reason why: Hospitals in neighborhoods with ... those in areas with more white residents, a U.S. ... are much less common in medical centers where the ... U.S. Centers for Disease Control and Prevention reported Thursday. ...
(Date:8/21/2014)... Aug. 21, 2014 (HealthDay News) -- Being born at a ... type 2 diabetes, a new study suggests. The findings ... population that has a high prevalence of low birth weight, ... black women found that those with a low birth weight ... than those with a normal birth weight. The risk of ...
(Date:8/21/2014)... HealthDay Reporter THURSDAY, Aug. ... and antidepressants appears to best help people with severe ... out of five people suffering from severe depression for ... with cognitive therapy plus antidepressant medication, researchers found. ... better than drugs alone in helping people with mild ...
(Date:8/21/2014)... August 21, 2014 Transvaginal mesh ... Inc. continue to move forward in the federal ... District of West Virginia, Bernstein Liebhard LLP reports. ... 14th, the Court has established new stipulated evidence ... handling, division, storage and preservation. (In re C.R. ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 Seattle, ... at Eastlake Chiropractic and Massage Center ... Center’s growing team. Rina Lang, LMP and Mike ... wide range of massage techniques, and have developed their ... This is particularly important in a clinical environment ...
Breaking Medicine News(10 mins):Health News:Racial Disparities in Breast-Feeding May Start With Hospitals, Study Suggests 2Health News:Low Birth Weights May Put Black Women at Risk for Diabetes 2Health News:Talk Therapy Plus Meds May Be Best for Severe Depression 2Health News:Talk Therapy Plus Meds May Be Best for Severe Depression 3Health News:Transvaginal Mesh Lawsuits Move Forward in Federal C.R. Bard Litigation with Issuance of New Pretrial Order, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuits Move Forward in Federal C.R. Bard Litigation with Issuance of New Pretrial Order, Bernstein Liebhard LLP Reports 3Health News:Seattle’s Eastlake Chiropractic and Massage Center Is Pleased to Introduce Rina Lang and Mike Larios as New Members of Its Massage Therapy Team 2Health News:Seattle’s Eastlake Chiropractic and Massage Center Is Pleased to Introduce Rina Lang and Mike Larios as New Members of Its Massage Therapy Team 3
... Gardner HealthDay Reporter , TUESDAY, Nov. 23 (HealthDay News) ... by almost 44 percent in those at highest risk for contracting ... new study finds. The reduction in risk climbed to nearly ... 90 percent of the time, the researchers added. Truvada is ...
... (CSCs), the aggressive cells thought to be resistant to current ... via a pathway that mirrors normal stem cell development. Disrupting ... breast CSCs, a finding that suggests a new drug therapy ... Proceedings of the National Academy of Sciences (PNAS) ...
... HealthDay Reporter , TUESDAY, Nov. 23 (HealthDay News) -- Being ... on a child,s IQ and ability to pay attention, new research ... (40 weeks) to those born between 34 to 36 weeks ... more than twice the risk of having an IQ score below ...
... By Amanda Gardner HealthDay Reporter , MONDAY, ... who are overweight actually perceive themselves as being normal weight, ... body weight actually fret that they,re too fat, according to ... to be often correlated with race: Black and Hispanic women ...
... Engineers have developed a new type of microchip muscle stimulator ... paralysed leg muscles. It is the first time ... is small enough to be implanted into the spinal canal ... The implant is the size of a child,s fingernail. ...
... their vision with perceptual training, according to a study from ... implications for the health and mobility of senior citizens. ... early stages of visual processing," appears in the current online ... funded by a $3.5 million grant from the National Institute ...
Cached Medicine News:Health News:Daily Pill Lowers Odds for Infection With HIV 2Health News:Daily Pill Lowers Odds for Infection With HIV 3Health News:Daily Pill Lowers Odds for Infection With HIV 4Health News:Discovery halts breast cancer stem cells 2Health News: Children Born 'Late Pre-Term' More Prone to Low IQ 2Health News: Children Born 'Late Pre-Term' More Prone to Low IQ 3Health News:1 in 4 Overweight Women Think They're Normal Size: Study 2Health News:1 in 4 Overweight Women Think They're Normal Size: Study 3Health News:New spinal implant will help people with paraplegia to exercise paralyzed limbs 2Health News:Perceptual training improves vision of the elderly 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: