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Human Genome Sciences Initiates First Clinical Trial of Lead IAP Inhibitor HGS1029 in Advanced Solid Tumors
Date:5/30/2008

- Primary study objectives include evaluation of safety and tolerability,

as well as selection of a recommended dose for Phase 2 trials -

ROCKVILLE, Md., May 30 /PRNewswire-FirstCall/ -- Human Genome Sciences, Inc. (Nasdaq: HGSI) today announced that it has initiated dosing in a Phase 1 clinical trial to evaluate the safety and tolerability of its lead IAP inhibitor, HGS1029, as monotherapy in patients with advanced solid tumors.

(Logo: http://www.newscom.com/cgi-bin/prnh/20080416/HGSLOGO )

"We are pleased to initiate this first human study of HGS1029, and we look forward to studying our IAP inhibitors both alone and in combination with other anti-cancer agents, including our TRAIL receptor antibodies," said Gilles Gallant, B. Pharm., Ph.D., Vice President, Clinical Research - Oncology, HGS.

HGS acquired exclusive worldwide rights (excluding Japan) to develop and commercialize HGS1029 (formerly AEG40826) and other IAP inhibitors from Aegera Therapeutics, Inc. in December 2007. When IAP proteins are over-expressed in cancer cells, they may help cancer cells resist apoptosis, or programmed cell death, and resume growth. The IAP inhibitors developed by Aegera, including HGS1029, are members of a new class of designed small-molecule drugs that block the biological activity of IAP proteins, thus allowing apoptosis to proceed and causing the cancer cells to die. Preclinical studies have shown that HGS1029 has significant anti-tumor activity alone and in combination with other anti-cancer agents, including the HGS TRAIL receptor antibodies, against a number of cancer types.

About the Phase 1 Trial Design

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SOURCE Human Genome Sciences, Inc.
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