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Human Genome Sciences Completes Enrollment of First Phase 3 Albuferon(R) Trial Ahead of Schedule
Date:8/28/2007

t in ACHIEVE 2/3 is also progressing well, and will be completed later in 2007.

"At the doses we are evaluating in Phase 3, Albuferon requires half as many injections as the pegylated interferons, and Phase 2 results suggest that it may offer efficacy at least comparable to peginterferon alfa-2a, with comparable safety and possibly less impairment of quality of life," said John McHutchison, M.D., Coordinating Center Principal Investigator for both Phase 3 trials, Professor of Medicine, Duke University Medical Center, and Associate Director, Duke Clinical Research Institute, Durham, N.C. "We are pleased with both the quality and the rapid progress of enrollment, and we look forward to continuing the evaluation of Albuferon in Phase 3 trials."

About the Albuferon Phase 3 Development Program

The Albuferon Phase 3 clinical development program includes two randomized, open-label, active-controlled, multi-center, non-inferiority trials -- ACHIEVE 1 and ACHIEVE 2/3 -- to evaluate the efficacy, safety and impact on health-related quality of life of Albuferon in combination with ribavirin versus Pegasys (peginterferon alfa-2a) in combination with ribavirin.

"The rapid pace of ACHIEVE 1 enrollment demonstrates a high level of interest in Albuferon among clinical investigators, as well as the significant need for improved treatment options for patients with chronic hepatitis C," said Mani Subramanian, M.D., Ph.D., Senior Director of Clinical Research, Infectious Diseases, HGS.

Higher doses of Albuferon administered monthly, in combination with ribavirin, will be explored in a separate Phase 2b trial conducted by Novartis, which is expected to begin later in 2007.

About Albuferon

Albuferon is a novel long-acting form of interferon alpha created by HGS using its proprietary albumin fusion technology. Albuferon results from the genetic fusion of human albumin and interferon alpha. Human albumin is the most prevalent naturally occurring bl
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SOURCE Human Genome Sciences, Inc.
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