Navigation Links
Human Genome Sciences Completes Enrollment in Randomized Phase 2 Trial of HGS-ETR1 in Non-Small Cell Lung Cancer
Date:8/22/2008

inical data suggests that combining HGS-ETR1 with chemotherapy agents could be an effective approach to the treatment of a number of malignancies, including non-small cell lung cancer," said Gilles Gallant, B. Pharm., Ph.D., Vice President, Clinical Research - Oncology, HGS. "HGS-ETR1 is the most advanced of any product in development that targets the TRAIL apoptotic pathway. The NSCLC study is one of three ongoing HGS trials designed to evaluate combinations of HGS-ETR1 with chemotherapeutic agents for the treatment of specific cancers."

About the HGS-ETR1 Proof-of-Concept Trials

The HGS-ETR1 proof-of-concept phase includes three randomized trials to evaluate its potential in combination with chemotherapy for the treatment of specific cancers:

-- Randomization and initial dosing of patients in the NSCLC study have now been completed.

-- In July 2008, HGS initiated dosing in the safety lead-in to a randomized Phase 2 trial of HGS-ETR1 in combination with Nexavar (sorafenib) in patients with advanced hepatocellular cancer, which accounts for 80-90% of all liver cancers.

-- The Company expects to have initial data available in the third quarter of 2008 from a randomized Phase 2 trial of HGS-ETR1 in combination with Velcade (bortezomib) in advanced multiple myeloma. Patients in the multiple myeloma study will continue on treatment until the progression of disease.

These three trials, taken together, will support a decision on whether to advance HGS-ETR1 to Phase 3 development. It also is possible that a sufficiently positive result from any one of the trials could lead to a Phase 3 decision for that specific indication.

About Non-Small Cell Lung Cancer

Non-small cell lung cancer accounts for approximately 75-80% of all lung cancers. It is estimated that more than 170,000 new cases and more than 160,000 deaths occur annually in the United States alone. It is currently the leading cause of cancer death in the U.S. i
'/>"/>

SOURCE Human Genome Sciences, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Boston University and The Center for Human Genetics, Inc. Announce Change in Testing Services
2. ViaViente Demonstrates Cardiovascular Benefits in New Human Trial
3. Lixte Biotechnology Holdings Announces That Novel Compounds Being Developed as Potential Treatments for Brain Tumors Have Positive Activity in a Mouse Model of Human Pancreatic Cancer
4. ProteoTechs Exebryl-1(R) Enters Human Clinical Trials for the Treatment of Alzheimers Disease
5. Medarex Announces Allowance of Investigational New Drug Application for Wholly-Owned Fully Human Anti-PD-L1 Antibody, MDX-1105
6. deCODE and SGENE Consortium Discover Deletions in the Human Genome Linked to Risk of Schizophrenia
7. New Research on Pre-Eclampsia in Mice May Have Important Implications for Humans
8. Ekkyo Describes the First Benefits of Controlled Hyperthermia in Humans in "Lasers in Surgery and Medicine"
9. Vical Announces Breakthrough for Pandemic Influenza DNA Vaccines With Preliminary Human Data
10. Insmed Announces First Human Bioequivalence Data for a Follow-on Biologic by a U.S. Company
11. IDM Pharma Provides Update on Mifamurtide (L-MTP-PE) Regulatory Status Following June Meeting of European Committee for Medicinal Products for Human Use (CHMP)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... 2015   , Boston Scientific to ... consideration of up to $1.65 billion, with $1.6 billion in ... alternatives for AMS, Women,s Health business , ... business Endo International plc (NASDAQ: ... into a definitive agreement with Boston Scientific (NYSE: ...
(Date:3/2/2015)...  BioMed Realty Trust, Inc. (NYSE: BMR ... feet of space in the most dynamic and valuable ... the termination of Vertex Pharmaceuticals, leases on three properties ... 28, 2015. BioMed Realty will receive a $14 million ... reposition the properties to meet the growing demand for ...
(Date:3/1/2015)... , March 1, 2015  An innovative interventional ... migraine sufferers sustained relief of their headaches, according ... of Interventional Radiology ,s Annual Scientific Meeting ... State University New York Empire State College in ... sphenopalatine ganglion (SPG) blocks to give patients enough ...
Breaking Medicine Technology:Endo Announces Divestiture of American Medical Systems' Men's and Prostate Health Businesses to Boston Scientific 2Endo Announces Divestiture of American Medical Systems' Men's and Prostate Health Businesses to Boston Scientific 3BioMed Realty Gets Back 313,000 Square Feet Of Valuable Real Estate In Cambridge Innovation District 2BioMed Realty Gets Back 313,000 Square Feet Of Valuable Real Estate In Cambridge Innovation District 3Image-guided treatment shown to break the migraine cycle 2Image-guided treatment shown to break the migraine cycle 3Image-guided treatment shown to break the migraine cycle 4
... of Proprietary siRNA Molecule in Acute ... ... Inc., a,development-stage pharmaceutical company focused on discovering and,developing novel RNA interference-based ... its proprietary product,candidate, AKIi-5, a siRNA compound discovered and developed by ...
... 16 AstraZeneca (NYSE:,AZN) today announced that the ... SEROQUEL XR(TM) (quetiapine fumarate) Extended-Release,Tablets for maintenance treatment ... the FDA approved SEROQUEL XR for the acute ... experience high rates of symptom relapse, and as,a ...
Cached Medicine Technology:Quark Pharmaceuticals, Inc. Announces First Systemic siRNA Dosing in Humans 2Quark Pharmaceuticals, Inc. Announces First Systemic siRNA Dosing in Humans 3Quark Pharmaceuticals, Inc. Announces First Systemic siRNA Dosing in Humans 4SEROQUEL XR(TM) Receives Approval From FDA for Maintenance Treatment of Schizophrenia 2SEROQUEL XR(TM) Receives Approval From FDA for Maintenance Treatment of Schizophrenia 3SEROQUEL XR(TM) Receives Approval From FDA for Maintenance Treatment of Schizophrenia 4SEROQUEL XR(TM) Receives Approval From FDA for Maintenance Treatment of Schizophrenia 5SEROQUEL XR(TM) Receives Approval From FDA for Maintenance Treatment of Schizophrenia 6SEROQUEL XR(TM) Receives Approval From FDA for Maintenance Treatment of Schizophrenia 7SEROQUEL XR(TM) Receives Approval From FDA for Maintenance Treatment of Schizophrenia 8
(Date:3/2/2015)... 2015 Éminence Organic Skin Care, the ... excited to announce the launch of the Balance Collection, ... time-saving solution for those with combination skin. The Balancing ... divided jar to separate the products, consists of the ... Balancing Moisturizer Duo, also in a divided jar, contains ...
(Date:3/1/2015)... To help healthcare organizations ... practices compliantly and profitably, MDreferralPRO and Vericle ... The interoperability between a strategic referral management ... management system is necessary for a healthcare ... referral management and development solution relies on ...
(Date:3/1/2015)... Women’s Excellence is pleased to announce the addition of a ... There are over 75 terms and phrases available for viewing, with ... our patients a better understanding of what our Providers are talking ... With this resource, our patients are able to go back ... phrases that they may not remember or comprehend at the time ...
(Date:3/1/2015)... 01, 2015 Adults who are not ... for term or universal policies can now use the ... best life insurance companies for single adults can now ... http://quotespros.com/life-insurance.html . , The rate plans that nationwide ... tied to a number of life protection policies. The ...
(Date:3/1/2015)... 01, 2015 Ticket Down is a reputable ... at Soldier Field. Deadheads have been anxiously anticipating ... , Grateful Dead was formed 50 years ago back in ... as one until the untimely death of Jerry Garcia in ... genres including blues, reggae, rock, bluegrass, folk, space rock and ...
Breaking Medicine News(10 mins):Health News:Éminence Organic Skin Care Launches Innovative Collection for Combination Skin 2Health News:Éminence Organic Skin Care Launches Innovative Collection for Combination Skin 3Health News:Power Up Physician and Patient Referral Management While Qualifying for ARRA Incentives 2Health News:Power Up Physician and Patient Referral Management While Qualifying for ARRA Incentives 3Health News:Power Up Physician and Patient Referral Management While Qualifying for ARRA Incentives 4Health News:Best Life Insurance Companies for Single Adults Now Searchable at Insurance Website 2Health News:Grateful Dead Tickets at Soldier Field in Chicago: Ticket Down Slashes Grateful Dead Ticket Prices in Chicago at Soldier Field for 4th of July Weekend Celebration 2
... have found that Nepali rhesus is by all means ... currently been used in biomedical research. // The Nepali ... prevailing shortage of laboratory animals used for developing of ... of the current issue of the American Journal of ...
... introduction of a UN AIDS report, UN officials were prompted ... in Myanmar and Vietnam // , which is inadequate prevention ... was originally a HIV/AIDS haven, has shown remarkable decline in ... measures to combat AIDS go slack, there is a risk ...
... the warmth of summer, mosquitoes too are out to suck ... could mean a lethal injection of many harmful diseases//. ... that Delaware offers an ambient atmosphere for mosquito to breed. ... top 10 in the United States in human population density ...
... to 24-year-old adults in UK revealed that above half of them ... intoxicate, about 18 per cent of people from all ages in ... cent of people in UK, who were aged between 18-24 and ... – said doctors. ,In Scotland nearly 27 per cent ...
... have agreed to cooperate in sharing key intelligence inputs ... drugs trafficking and assist each other in disaster management. ... intelligence and information in these key security-related areas and ... of disaster management," a senior official told PTI Wednesday ...
... agitating medicos today on the future course of their anti-reservation// ... Court to resume duties immediately. ,A section of ... strike to honor the apex court direction, while others say ... was not addressed to medical students., ,Sources said heated ...
Cached Medicine News:Health News:Nepali Rhesus May be Used as an Alternate for HIV/AIDS Research 2Health News:Nepali Rhesus May be Used as an Alternate for HIV/AIDS Research 3
Phaco-emulsification systems CV series...
The unprecedented power, flexibility and versatility of the Series 20000 Legacy have made it the world's leading phacoemulsifier....
Foreign body removal system. Designed to aid in the removal of foreign bodies and corneal rust rings....
Foreign body removal system. Designed to aid in the removal of foreign bodies and corneal rust rings....
Medicine Products: