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Human Genome Sciences Announces Full Presentation of Quality-of-Life Results From Phase 2b Trial of Albuferon(R) for Hepatitis C
Date:11/5/2007

ork days compared with peginterferon alfa-2a, and also achieved statistically and clinically meaningful differences in many of the SF-36 quality-of-life domains."

Key Quality-of-Life Findings from the Phase 2b Study

Working patients in all Albuferon treatment groups recorded fewer days of missed work than was observed in the peginterferon alfa-2a treatment group. All Albuferon groups showed less impairment of health-related quality of life based on SF-36 physical and mental component summary scores.

Significantly fewer working patients taking Albuferon 900 mcg every two weeks reported missing 7 days or more of work during the month prior to their treatment visits at Weeks 12 and 24, vs. patients taking peginterferon alfa- 2a. At week 12, only 4.2% of patients taking Albuferon 900 mcg every two weeks had missed 7 or more days of work the previous month, compared with 18.1% of peginterferon alfa-2a patients (p<.05). At week 24, only 5.3% of Albuferon 900-mcg patients had missed 7 or more days of work the previous month, compared with 20.3% of peginterferon alfa-2a patients (p<.05). At Week 12, working patients taking Albuferon 900-mcg every two weeks reported missing an average of 1.1 days of work during the previous month, while peginterferon alfa-2a patients reported missing an average of 4.3 work days (p<.05). At Week 24, Albuferon 900-mcg patients had missed an average of 1.6 days of work during the previous month, while peginterferon alfa-2a patients had missed an average of 4.7 work days.

At Weeks 12 and 24, the treatment group taking Albuferon 900 mcg every two weeks also reported better scores for all eight SF-36 physical and mental health domains, as well as the physical and mental summary scores, compared with peginterferon alfa-2a. Statistically significant and clinically meaningful differences were observed in the mental health, bodily pain, vitality and social functioning domains. By the Week 12 follow-up visit after the end of tre
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SOURCE Human Genome Sciences, Inc.
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