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Huge Drop in Preterm Birth-Risk Among Women Taking Folic Acid One Year Before Conception
Date:1/31/2008

Largest U.S. Study of Pre-conceptional Folic Acid Supplementation Receives March of Dimes Award

DALLAS, Jan. 31 /PRNewswire-USNewswire/ -- New research suggests that women who take folic acid supplements for at least one year before they become pregnant can cut their risk of having a premature baby by half.

Researchers at the 28th Annual Society for Maternal-Fetal Medicine (SMFM) meeting -- The Pregnancy Meeting(TM)-- today unveiled a study linking pre-conceptional folate supplementation of at least one year to reduced early premature delivery rates of 50 to 70 percent, regardless of age, race or other factors. Of particular note is the drop in very early premature births, those babies who are at the greatest risk of complications such as cerebral palsy, mental retardation, chronic lung disease, and blindness.

The study is an observational analysis based on the self-reporting of folate supplementation by 38,033 participants in an earlier trial sponsored by the National Institutes of Health (NIH.) The current study only examined singleton pregnancies and excluded pregnancies in which there were medical or obstetrical complications such as preeclampsia, chronic hypertension, and congenital or chromosomal abnormalities.

"Thanks to the depth and breadth of the NIH study, which included an early pregnancy ultrasound of each participant, we had highly accurate evidence of the gestational ages of the preterm deliveries," said Radek Bukowski, M.D., Ph.D., assistant professor, Obstetrics and Gynecology, at the University of Texas Medical Branch at Galveston, the lead study author and SMFM member. "This evidence enabled us to determine that folate supplementation for at least one year is linked to a 70 percent decrease in very early preterm deliveries (20 to 28 weeks in gestational age) and up to a 50 percent reduction in early preterm deliveries of 28 to 32 weeks."

"We already knew that folic acid supplementation beginning
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SOURCE March of Dimes
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