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Howard Leonhardt to Present 25 Years of Experience With Stem Cell Transplantation at 28th Annual Interventional Cardiology Conference in Snowmass, Colo., on March 28
Date:3/26/2013

. Bioheart and Leonhardt Ventures have supported close to 40% of this total.
  • Pre-treating scar with microRNAs, stromal cell-derived factor-1 (SDF-1) and hydrogel can improve results.
  • Genetically modifying cells to over-express SDF-1 can double improvement results and the consistency of results. Myoblasts alone lead to 27% improvement, while SDF-1 myoblasts result in 54% improvement. 66% of patients received substantial new muscle formation with SDF-1 myoblasts compared to 33% with ordinary myoblasts.
  • New muscle formed with myoblasts is stretch-activated.
  • Injected cardiac stem cells or induced pluripotent stem (iPS) cells at the rim edge of scar and myoblasts in the center of scar in combination may be worth studying.
  • Electrical stimulation before, during and after stem-cell transplantation can dramatically improve results.
  • Nutrient hydrogel can help improve myoblast cell engraftment in scar tissue.
  • Repeat injection sessions can dramatically improve results. It is believed now up to 36 sessions of percutaneous injections of 300 million cells each may be needed for full myocardial scar recovery.
  • For more information on the 28th Annual International Symposium of Interventional Cardiology, see http://www.interventionalcardiol.com. To learn more about Bioheart's advances in regenerative medicine, visit http://www.bioheartinc.com.

    About Leonhardt Ventures: Since 1983 Leonhardt Ventures http://www.leonhardtventures.com has a strong history of inventing, developing, backing and bringing to market leadership products for treating heart and cardiovascular disease. Over 200,000 patients have been treated to date with Leonhardt inventions. In the 1980s, the group developed market leadership in patented polyurethane balloon catheters includ
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    SOURCE Bioheart, Inc.
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