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Howard Leonhardt to Present 25 Years of Experience With Stem Cell Transplantation at 28th Annual Interventional Cardiology Conference in Snowmass, Colo., on March 28
Date:3/26/2013

ssue is far superior to coronary infusion or other methods.
  • Targeted cell delivery is not needed. The cells naturally spread all over scar tissue if they are injected anywhere near the scar tissue and migrate to the injured tissue areas.
  • In trials, 84% of myoblast-treated heart-failure patients have improved; only 16% worsened.
  • 69% of non-treated control or placebo patients in trials have worsened.
  • 33% of myoblast-treated patients with only one injection session exhibited substantial improvement.
  • Myoblast-treated patients improved 95.7 meters over placebo patients (-4 meters decline) in exercise capacity in controlled clinical trials. No other stem cell type, drug or device has ever beat 53 meters improvement in a controlled trial; cardiac resynchronization therapy (CRT) pacers achieved an improvement of 20 meters, cardiac stem cells increased exercise capacity by 53 meters, while drugs were associated with a 4-meter decline.
  • It is expected that repeat myoblast transplantation will reduce by half hospitalizations from heart failure. Heart-failure hospitalizations and associated care are the single leading drain on Medicare in the USA.
  • Myoblast-transplanted patients have a lower incidence of serious arrhythmias six months and one year after treatment than non-treated patients. Premature ventricular contraction (PVC) data demonstrates 0.05% for myoblast-treated patients and 3% for non-treated patients.
  • 33% of myoblast-treated patients improve two heart failure classes.
  • 33% of myoblast-treated patients have greater than 15% improvement in left ventricular ejection fraction (LVEF) via dobutamine stress echo studies.
  • Pressure-volume (PV) loop studies have demonstrated myoblast-treated patients have substantial positive reverse re-modeling.
  • Close to $300 million has been spent to date on myoblast transplantation for heart failure research
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  • SOURCE Bioheart, Inc.
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