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How IT Helps Solve Pharma's R&D Problems: in silico Drug Discovery
Date:11/8/2010

the life sciences industry 26

Solutions to improve lead generation and predictive ADMET need to be priorities 27

Develop a sound service strategy as computational biologists and chemists are in high demand 27

APPENDIX 28

Ask the analyst 28

Definitions 28

Further reading 29

Methodology 29

Disclaimer 30

LIST OF TABLES Table 1: Definitions of key drug discovery processes 16

LIST OF FIGURESFigure 1: Deficit in global annual sales for the top 50 pharma companies due to patent expiries through 2014 6

Figure 2: The pharma industry's sales growth with flat-line to 2014 7

Figure 3: The growing cost of drug discovery and allocation of R&D investment by function (%), 1975-2008 8

Figure 4: Productivity continues to decline across the US, Europe and Japan , 1989-2008 9

Figure 5: Top priorities of life sciences executives 10

Figure 6: PhRMA R&D as a proportion of sales (%), 1975-2008 13

Figure 7: Percent of life sciences companies' IT budgets allocated to various phases of the drug lifecycle 13

Figure 8: The impact of in silico models on drug compound testing and drug time-to-market 14

Figure 9: Current drug discovery and development process 15

Figure 10: R&D process with in silico research incorporated 18

Figure 11: Matrix of vendors that provide in silico technologies and support 24

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