Navigation Links
Horizon Therapeutics Presents Phase 3 Study Results Identifying Risk Factors for Ulcer Development Among NSAID Users
Date:10/26/2009

strointestinal (GI) ulcer and/or prohibitive toxicity. Results showed that patients with mild-to-moderate pain treated with HZT-501 developed approximately 50 percent fewer NSAID-associated upper GI ulcers compared to patients treated with ibuprofen alone.

The statistical analysis looked at the combined 1,382 patients studied in the REDUCE-1 and REDUCE-2 primary study populations (HZT-501, N=930; ibuprofen, N=452). The predefined population for primary analyses of upper GI ulcers was all patients with at least one on-study endoscopy (EGD). The life table analysis estimate showed that fewer patients taking HZT-501 developed upper GI ulcers than those taking ibuprofen alone after 24 weeks (14.1% vs. 26.5%, p<0.0001). A multivariable proportional hazard regression analysis was done to assess potential risk factors for upper GI ulcer development in the combined studies. The following chart highlights the most prevalent risk factors derived from the analysis:



                   Analysis Factor                Relative Risk (95% CI)
                   ---------------                ---------------------
           Ibuprofen (without famotidine)           2.18 (1.64, 2.90)

                     Prior ulcer                    1.65 (1.01, 2.69)

                      Age >=65                      1.54 (1.10, 2.17)

                  Low-dose aspirin                  1.46 (1.00, 2.11)

                       Female                       1.15 (0.84, 1.57)

       Baseline erosions (GI erosions noted on
        baseline endoscopy at the start of the
        study)                                      1.15 (0.82, 1.62)


"By identifying these independent risk factors, physicians may be able to better assess a patient's risk for NSAID-associated GI toxicity," said Timothy P. Walbert, president and chief executive officer of Horizon Therapeutics. "For patients with chronic pain who are at increased GI risk, HZT-501 may be an importan
'/>"/>

SOURCE Horizon Therapeutics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Horizon Therapeutics HZT-501 Significantly Reduces Incidence of NSAID-Induced Upper Gastrointestinal Ulcers in Patients With Mild-to-Moderate Pain
2. Boston Scientific Welcomes Publication of HORIZONS AMI Trial Results in New England Journal of Medicine
3. Horizon Therapeutics Announces Two Pivotal HZT-501 Phase 3 Trials Meet Primary Endpoints
4. HORIZONS AMI Trial Demonstrates Superior Outcomes with TAXUS(R) Drug-Eluting Stents in Heart Attack Patients
5. Horizon Therapeutics Completes Enrollment in Phase 3 Trials for Lead Product Candidate HZT-501
6. GlaxoSmithKline and Theravance Announce Start of Large Phase 2B ICS and LABA Studies for Asthma in the Horizon Program
7. Horizon Therapeutics Initiates Long-Term Phase 3 Safety Study for Lead Product Candidate HZT-501
8. Inhibikase Therapeutics Discusses New Platform for Infectious Disease Pharmaceuticals at BIOCOM 2009
9. Cell Therapeutics, Inc. (CTI) to Present at 8th Annual BIO Investor Forum
10. Cell Therapeutics, Inc. Reports Outcome of Annual Meeting of Shareholders
11. Logical Therapeutics to Present Data on LT-NS001 at American College of Gastroenterology Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2015)... , March 3, 2015 Konica Minolta ... announced today a new, integrated portable X-ray ... solution is now available with a larger integrated console, ... mounted system offers a larger viewing area to simplify ... provides additional space for accessories and storage, along with ...
(Date:3/3/2015)... 3, 2015  Columbia Laboratories, Inc. (Nasdaq: ... Company"), a specialty pharmaceutical company focused on pharmaceuticals for ... the 27th Annual ROTH Conference, which will take place ... Dana Point, California . Management,s presentation ... a.m. Pacific Time (12:00 p.m. Eastern Time) in the ...
(Date:3/3/2015)... 2015  Web Industries, Inc., a leading provider ... Medical Device, Advanced Composites, Consumer Products, and Wire ... Medical Specialties Preferred Converter by 3M,s Medical Specialties ... to streamline their supply chains by using Web ... materials, intermediate converting services, and contract manufacturing and ...
Breaking Medicine Technology:Konica Minolta Medical Imaging and Shimadzu Medical Systems USA Introduce MobileArt Evolution EFX AeroDR-i with 17" Touch Monitor to Simplify Operation 2Konica Minolta Medical Imaging and Shimadzu Medical Systems USA Introduce MobileArt Evolution EFX AeroDR-i with 17" Touch Monitor to Simplify Operation 3Web Industries Receives 3M Preferred Converter Status 2
... advanced leukemia and myelodysplastic, syndrome patients presented ... N.J., Dec. 10 Celator Pharmaceuticals today,announced results ... a liposomal,formulation that incorporates a synergistic ratio of ... and myelodysplastic,syndromes. While dose escalation in the study ...
... Dec. 10 The US Food and,Drug Administration ... small,open, long-term, clinical studies in patients with gastro-esophageal ... study) or NEXIUM(R) (LOTUS study) treatment., AstraZeneca ... conclusion which states,"FDA continues to conclude that long-term ...
Cached Medicine Technology:Celator(R) Pharmaceuticals Reports CPX-351 Shows Anti-Cancer Activity in Leukemia Patients 2FDA Concludes There is No Increased Risk of Cardiac Events for Patients Treated with omeprazole and NEXIUM(R) (esomeprazole magnesium) 2FDA Concludes There is No Increased Risk of Cardiac Events for Patients Treated with omeprazole and NEXIUM(R) (esomeprazole magnesium) 3FDA Concludes There is No Increased Risk of Cardiac Events for Patients Treated with omeprazole and NEXIUM(R) (esomeprazole magnesium) 4
(Date:3/3/2015)... Daylight Savings Time may lead to your kids ... for parents. , Parents and their children may feel a ... they set their clocks forward one hour for Daylight Savings ... one hour earlier -- you will have already lost one ... about “sleep hygiene” for their kids and teens this week, ...
(Date:3/3/2015)... 03, 2015 Topical BioMedics, Inc., announces its ... streamed live on Tuesday, March 10th, 12pm – 1pm and ... and accessible 24/7. , The Pain Management ... for the March 10th workshop is “Opioid Addiction: An ... the U.S. represents 5% of the world’s population, yet consumers ...
(Date:3/3/2015)... MD (PRWEB) March 03, 2015 Today ... Association (ASHA) is using the occasion to applaud and ... campaign by the World Health Organization (WHO) for stemming ... campaign aims to encourage young people to practice safe ... audio technology, attending concerts or sporting events, or engaging ...
(Date:3/3/2015)... (PRWEB) March 03, 2015 The ... better predict antidepressant treatment outcomes for patients with ... than any of the individual genes that comprise ... investigators from the Mayo Clinic and Assurex Health, ... , The proprietary technology of the GeneSight ...
(Date:3/3/2015)... With a grant of more than $4.5 ... has been named a national coordinating center by the ... for Health: Improving Community Health Through Innovations in Financing ... health and reduce disparities through innovations in collaboration and ... of the center and up to 10 communities over ...
Breaking Medicine News(10 mins):Health News:Don’t Let Daylight Savings Disrupt Your Child’s Sleep 2Health News:Topical BioMedics Hosts March Pain Management Webinar 2Health News:Topical BioMedics Hosts March Pain Management Webinar 3Health News:Topical BioMedics Hosts March Pain Management Webinar 4Health News:Topical BioMedics Hosts March Pain Management Webinar 5Health News:ASHA Applauds Launch of New WHO Campaign 2Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 2Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 3Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 4Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 5Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 6Health News:Robert Wood Johnson Foundation Names Georgia Health Policy Center National Center for Bridging for Health Initiative 2
... have now proved using a specialized mouse model that ... neurons.// The results of this study have for the ... ,Also known as apoE, this cholesterol-carrying protein ... the major known genetic risk factor for Alzheimer's disease, ...
... published in the journal Carcinogenesis show that exercise can offer ... that had a round the clock access to wheels took ... that exercise and a restricted diet had a healthy effect ... ,The first study exposed mice to ultraviolet B ...
... Dental Health Foundation has found that more than 60 percent ... clean off food debris// struck in between their teeth. Items ... use, the survey said. ,More disturbingly, the survey ... teeth giving rise to oral health problems and bad breath. ...
... the form of health claims that green tea is no ... a model qualified health// claim says "Daily consumption of at ... a source of catechins may reduce a number of risk ... evidence is supportive, but not conclusive, for this claim. (Green ...
... (AIIMS) here is running short of faculty members and its ... informed Friday. ,Replying to a question, minister of state ... AIIMS was running with just 479 faculty members as against ... the house that during 2003-05, 20 faculty members had either ...
... rate in Madhya Pradesh, Bhopal Archbishop Pascal Topno has ... ,With 13,000 reported deaths every year during or ... is one of the highest in the country. ... Niketan Welfare Centre here, Topno urged them to tap ...
Cached Medicine News:Health News:Alzheimer's-linked apolipoprotein E produced by neurons, Gladstone study 2Health News:Green tea’s health claims questioned: FD 2Health News:Green tea’s health claims questioned: FD 3
Cushing bayonet....
Straight, blunt tips....
Angled, pointed, with attached cable for Valleylab and other brands generators....
Autoclavable reusable pencil for Aaron 800 & 1200 - comes with generator or 1/box....
Medicine Products: