Navigation Links
Horizon Therapeutics Presents Phase 3 Study Results Identifying Risk Factors for Ulcer Development Among NSAID Users
Date:10/26/2009

SAN DIEGO, Oct. 26 /PRNewswire/ -- Horizon Therapeutics, Inc., a privately held biopharmaceutical company, today presented an analysis from two pivotal Phase 3 trials (REDUCE-1 and REDUCE-2) evaluating its lead investigational compound HZT-501, a combination of ibuprofen with high-dose famotidine. The analysis, which was designed to identify risk factors for the development of non-steroidal anti-inflammatory drug (NSAID)-associated ulcers, was presented at the 74th American College of Gastroenterology (ACG) Annual Scientific Meeting.

"Upper gastrointestinal tract ulcers develop commonly in people taking NSAIDs and can occur without warning symptoms. Historically there have been limited data identifying the factors that predict an increased risk of finding ulcers in NSAID users," said Loren Laine, MD, University of Southern California Keck School of Medicine and lead investigator. "Data collected from the REDUCE-1 and REDUCE-2 trials provide insight into these risk factors. The statistically significant independent risk factors included the use of the NSAID ibuprofen without the histamine-2 receptor antagonist famotidine, previous ulcer disease and older age."

The two pivotal Phase 3 clinical trials, REDUCE-1 and REDUCE-2 (Registration Endoscopic Studies to Determine Ulcer Formation of HZT-501 Compared to Ibuprofen: Efficacy and Safety Studies), conducted via a Special Protocol Assessment (SPA) with the U.S. Food and Drug Administration (FDA), were randomized, double-blind, controlled trials that enrolled more than 1500 patients with mild-to-moderate pain. Patients were randomly assigned, in approximately a 2:1 ratio, to receive either HZT-501 (800 mg ibuprofen and 26.6 mg famotidine) or the NSAID ibuprofen (800 mg) alone orally three times daily for a 24-week treatment period or until patients developed either an endoscopically diagnosed upper ga
'/>"/>

SOURCE Horizon Therapeutics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Horizon Therapeutics HZT-501 Significantly Reduces Incidence of NSAID-Induced Upper Gastrointestinal Ulcers in Patients With Mild-to-Moderate Pain
2. Boston Scientific Welcomes Publication of HORIZONS AMI Trial Results in New England Journal of Medicine
3. Horizon Therapeutics Announces Two Pivotal HZT-501 Phase 3 Trials Meet Primary Endpoints
4. HORIZONS AMI Trial Demonstrates Superior Outcomes with TAXUS(R) Drug-Eluting Stents in Heart Attack Patients
5. Horizon Therapeutics Completes Enrollment in Phase 3 Trials for Lead Product Candidate HZT-501
6. GlaxoSmithKline and Theravance Announce Start of Large Phase 2B ICS and LABA Studies for Asthma in the Horizon Program
7. Horizon Therapeutics Initiates Long-Term Phase 3 Safety Study for Lead Product Candidate HZT-501
8. Inhibikase Therapeutics Discusses New Platform for Infectious Disease Pharmaceuticals at BIOCOM 2009
9. Cell Therapeutics, Inc. (CTI) to Present at 8th Annual BIO Investor Forum
10. Cell Therapeutics, Inc. Reports Outcome of Annual Meeting of Shareholders
11. Logical Therapeutics to Present Data on LT-NS001 at American College of Gastroenterology Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)...  Actavis plc (NYSE: ACT ) ... complete response letter from the U.S. Food and ... (NDA) for the fixed-dose combination (FDC) of nebivolol ... Photo - http://photos.prnewswire.com/prnh/20130124/NY47381LOGO ... of a complete response letter, Actavis remains committed ...
(Date:12/24/2014)... 24, 2014 /PRNewswire/  -- Tianyin Pharmaceutical Inc. (NYSE ... that specializes in the patented biopharmaceutical, modernized traditional ... ingredients (API) released unaudited preliminary financial results for ... Fiscal Year 2015 Ended September 30, 2014 ... compared with $14.7 million in 1Q14 with gross ...
(Date:12/24/2014)... , Dec. 24, 2014 Soligenix, Inc. ... biopharmaceutical company developing products that address unmet medical ... biodefense, announced today that on December 24, 2014 ... The Company raised approximately $2.3 million ... to use the net proceeds from the offering ...
Breaking Medicine Technology:Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 2Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 3Actavis Confirms Complete Response Letter for Nebivolol/Valsartan Fixed-Dose Combination for Hypertension 4TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 2TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 3TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 4TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 5TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 6TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 7TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 8TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 9TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 10TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 11TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 12Soligenix Announces Closing of Public Offering of Units 2Soligenix Announces Closing of Public Offering of Units 3
... Lower Body InjuriesCINCINNATI, May 5 In comparison to ... have lower body injuries, such as in their ankles ... which was conducted to determine if different body parts ... so that prevention strategies can be developed, was presented ...
... Disease Presented at Pediatric Academic Societies, Annual MeetingBALTIMORE, ... a recent study it sponsored, performed by the ... assessing risk factors for respiratory syncytial virus (RSV) ... 33 weeks gestational age [GA] or later. The ...
Cached Medicine Technology:The Injured Obese Child: Let's Give Him Some Ankle Support 2The Injured Obese Child: Let's Give Him Some Ankle Support 3MedImmune Presents New Data Demonstrating Increased Risk for Medically Attended RSV in Late-Preterm Infants 2MedImmune Presents New Data Demonstrating Increased Risk for Medically Attended RSV in Late-Preterm Infants 3
(Date:12/25/2014)... 25, 2014 Residents at ... recently showed their generous spirit by providing holiday ... County Parenting Network- Grandparents Raising Grandchildren program. , ... around the largest Christmas tree on the campus ... by residents of the Abernethy Village Association (AVA). ...
(Date:12/24/2014)... AlignLife of Wauwatosa loves helping those in the ... holiday season, AlignLife looks forward to their annual toy drive. ... Mahalko-Leonhardt, owner of AlignLife. "It brings our patients as well ... able to give kids toys for Christmas who would be ... of our patients." , The 70 toys were donated to ...
(Date:12/24/2014)... Connie Casad, MD, a well-known and respected gynecologist, ... years of practice experience in Dallas, Texas, has announced ... dietary detoxification. The second study is scheduled to begin ... test patients who just completed a 21-day detoxification regimen. ... conducting the study, Dr. Casad said, "About 10 years ...
(Date:12/24/2014)... 24, 2014 New studies reveal that women ... loss related depression (March 6, 2014, JAMA Otolaryngology*). And although ... loss (about 50 percent according to recent polls) facing hearing ... how a person feels and relates to the world. People ... are also made by way of:, , ...
(Date:12/24/2014)... UWDress.com, the famous women’s dress supplier, has presented its new ... wedding gown promotion. , For those who prefer ... way, the collection should be a great choice. The dresses ... they are available with custom service. , Now, all the ... to 75% off; most of them come in hot designs. ...
Breaking Medicine News(10 mins):Health News:Retirement Community Residents Make Impact During Holiday Season 2Health News:AlignLife of Wauwatosa Brings Joy to Less Fortunate Families 2Health News:Connie Casad, MD, Now Accepting Test Participants for January Dietary Detoxification Study 2Health News:Connie Casad, MD, Now Accepting Test Participants for January Dietary Detoxification Study 3Health News:Recent Studys Underscore the Fact That One of the Best Gifts to Give This Holiday Season is a Hearing Test 2Health News:Recent Studys Underscore the Fact That One of the Best Gifts to Give This Holiday Season is a Hearing Test 3Health News:Recent Studys Underscore the Fact That One of the Best Gifts to Give This Holiday Season is a Hearing Test 4Health News:Recent Studys Underscore the Fact That One of the Best Gifts to Give This Holiday Season is a Hearing Test 5Health News:Recent Studys Underscore the Fact That One of the Best Gifts to Give This Holiday Season is a Hearing Test 6Health News:Buy Cheap Long Sleeve Wedding Gowns At UWDress.com 2
Dengue, the mosquito-transmitted lethal disease that has claimed 15 lives and afflicted 1,000 people in West Bengal so far, has been declared an epidemic by the state government.// ,State Health Dir...
... discovered a new way to test the stem cells ... ,The researchers had used a non-invasive imaging ... after being injected into the body to treat animal ... ,In the study, researchers surgically induced acute ...
... alcohol-based hand sanitizer gel significantly reduces the spread of ... 292 families studied, half of the families, which used ... % reduction in the spread of illness related to ... sanitizer were excluded from the study. Half the families ...
... aortic valve in the heart is the valve that governs the ... which supplies blood to various organs of the body. // It ... rest of the body. ,The effective functioning of the heart ... valve can be defective in some cases, leading to a compromise ...
... India's Health Minister Anbumani Ramadoss Monday said that ... its national immunisation programme// as it has been ... ,Addressing the valedictory function of an Indian Council ... training workshop on laboratory diagnosis of leptospirosis at ...
... of the clinical study carried out by Professor Ian Reed ... Zealand has found that the drug Zometa manufactured by Novartis ... by Procter and Gamble. ,Paget's disease is a ... than the normal and the new bone replacement does not ...
Cached Medicine News:Health News:Alcohol based sanitizer found to reduce illness in families 2Health News:Percutaneous aortic valve replacement- a revolution in Cardiac Surgery 2
The original Zeppelin High-Speed Motordrill System has been developed to rapidly cut bone, plastic and metal with utmost precision. 120-150 psi - 90.000 rpm - 90g - autoclavable at <134 C....
... The Black Max is a ... for the rapid dissection of ... The Black Max not only ... also allows for the control ...
Legend Gold is the most powerful of the new motors. It runs at an impressive 76,000 rpm at 120 psi/8 bar. It is also smaller than the Midas Rex Classic motor, with an enhanced ergonomic design....
... Gold Touch motor is the first true high-speed, ... Gold Touch is comparable to Legend Gold and ... The telescoping lever design provides ergonomic positioning and ... Midas Rex Classic, the Legend Gold Touch is ...
Medicine Products: