Navigation Links
Horizon Therapeutics' HZT-501 Significantly Reduces Incidence of NSAID-Induced Upper Gastrointestinal Ulcers in Patients With Mild-to-Moderate Pain
Date:6/1/2009

--Data from Phase 3 REDUCE-1 and REDUCE-2 Studies Demonstrate that Novel Combination Treatment Decreases Risk of Developing GI Ulcers by Approximately 50 Percent--

--Data presented today at 56th Annual Digestive Disease Week Meeting in Chicago--

CHICAGO, June 1 /PRNewswire/ -- Horizon Therapeutics, Inc., a privately held biopharmaceutical company, today presented data at the 56th Annual Digestive Disease Week (DDW) meeting from two pivotal Phase 3 trials evaluating its lead compound HZT-501, which demonstrated that patients with mild-to-moderate pain treated with HZT-501 developed 50 percent less NSAID-induced upper gastrointestinal (GI) ulcers (gastric and/or duodenal ulcers) compared to patients treated with ibuprofen alone. HZT-501 is a novel, proprietary fixed-dose combination tablet containing the most prescribed non-steroidal anti-inflammatory drug (NSAID), ibuprofen, and famotidine, the most potent H2 antagonist.

"NSAIDs, such as ibuprofen, are among the most widely used drugs in the world," said Loren Laine, MD, professor of medicine, University of Southern California. "NSAIDs are effective at treating pain, but they also increase the risk of developing ulcers in the stomach or intestine and the risk of developing ulcer complications, such as bleeding. Patients at increased risk for gastrointestinal ulcers may benefit from protective co- therapy, although many such patients do not receive or adhere to this co-therapy."

The presentation at DDW included data from more than 1,300 evaluable patients who participated in the Registration Endoscopic Study to Determine Ulcer Formation of HZT-501 Compared to Ibuprofen: Efficacy and Safety Study, or REDUCE-1 and REDUCE-2. The primary objective of these studies was to evaluate the proportion of patients treated with HZT-501 (800 mg ibuprofen a
'/>"/>

SOURCE Horizon Therapeutics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Horizon Therapeutics Initiates Long-Term Phase 3 Safety Study for Lead Product Candidate HZT-501
2. GlaxoSmithKline and Theravance Announce Start of Large Phase 2B ICS and LABA Studies for Asthma in the Horizon Program
3. Horizon Therapeutics Completes Enrollment in Phase 3 Trials for Lead Product Candidate HZT-501
4. HORIZONS AMI Trial Demonstrates Superior Outcomes with TAXUS(R) Drug-Eluting Stents in Heart Attack Patients
5. Horizon Therapeutics Announces Two Pivotal HZT-501 Phase 3 Trials Meet Primary Endpoints
6. Boston Scientific Welcomes Publication of HORIZONS AMI Trial Results in New England Journal of Medicine
7. Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA
8. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
9. Amicus Therapeutics Announces Second Quarter 2007 Financial Results
10. TorreyPines Therapeutics Completes Patient Enrollment in Phase IIb Clinical Trial of Tezampanel for the Treatment of Acute Migraine Headache
11. CV Therapeutics Announces Eight Abstracts Accepted for Presentation at the European Society of Cardiology Congress 2007
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... 28, 2015  Perrigo Company plc ("Perrigo") (NYSE: ... the acquisition of leading OTC brands from GSK in ... transaction is a clear demonstration of Perrigo,s unique ability ... distribution network spanning 36 countries.  Perrigo ... commented, "We are excited to complete this transaction, which ...
(Date:8/28/2015)... Massachusetts y LONDRES, 28 de agosto ... AEX: PHIA) anunció hoy su participación en el  ... exhibirá sus soluciones cardiológicas más recientes y novedosas, ... Cardiovascular, que conectan a las personas y la ... de ayudar a diagnosticar, guiar los tratamientos y ...
(Date:8/27/2015)... DURECT Corporation (Nasdaq: DRRX ) announced ... upcoming healthcare conferences.  , James ... the Rodman & Renshaw Investment Conference on Thursday, September ... being held at the St. Regis Hotel in ... webcast of the presentation will be available by accessing ...
Breaking Medicine Technology:Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 2Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 3Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 4Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 2Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 3Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 4Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 5DURECT to Participate in Upcoming Healthcare Conferences 2
... , ALLEGAN, Mich., Nov. 19 Perrigo Company ... and CEO Joseph C. Papa will present at the Sidoti ... (EST) at the Grand Hyatt Hotel in New York City. ... supplier that develops, manufactures and distributes OTC and prescription pharmaceuticals, ...
... Nov. 19 Delcath Systems, Inc. (Nasdaq: DCTH ), ... (PHP(TM)) System, a minimally invasive drug delivery platform for the ... on the Company,s recent progress. , "Since we last communicated ... many significant milestones as we move into the first regulatory ...
Cached Medicine Technology:Delcath Systems Reports Substantial Progress 2Delcath Systems Reports Substantial Progress 3Delcath Systems Reports Substantial Progress 4
(Date:8/29/2015)... ... ... Dr. Tim Novelli, DC., Founder and President of the Patriot Project, is ... chiropractic field in the military. All too often VA hospitals treat patients with harmful ... to the VA program over a decade ago, the reality is that only 10% ...
(Date:8/29/2015)... , ... August 29, 2015 , ... ... include treating the localized area with stretching, soft tissue manipulation. Platelet rich plasma ... position have shown through research to improve treatment outcomes. This localized treatment ...
(Date:8/28/2015)... ... August 28, 2015 , ... An online provider of CPAP machines, ... purchase of CPAP equipment more affordable by offering shipping at no cost to you, ... products and orders of any size. My Cpap Store is located in Las Vegas, ...
(Date:8/28/2015)... Dallas, TX (PRWEB) , ... August 28, 2015 , ... ... Surgical Center is taking part with their subsidiary USPI Tenet Health. , The American ... to fight heart disease and stroke. They believe that together, a difference can be ...
(Date:8/28/2015)... ... August 28, 2015 , ... Loved ones ... personally be struggling with chemical dependency, may be able to find some hope ... results-driven holistic treatment center for addiction located in Western Michigan. Focusing on several ...
Breaking Medicine News(10 mins):Health News:The Patriot Project brings Chiropractic Care to the Armed Forces and their Families - Rapid Release Technology Joins the Effort to Recruit more Doctors to Pledge 2Health News:NEW APPROACH for Treatment of Recurrent Hamstring Strains and Hamstring Tendinosis is Available for the First Time in NYC 2Health News:NEW APPROACH for Treatment of Recurrent Hamstring Strains and Hamstring Tendinosis is Available for the First Time in NYC 3Health News:My Cpap Store Now Offering Delivery Special 0 Cost to You 2Health News:North Central Surgical Center’s Subsidiary Participates in Walk 2Health News:Best Drug Rehabilitation Releases New Video Outlining Patients' Personal Recovery Stories 2Health News:Best Drug Rehabilitation Releases New Video Outlining Patients' Personal Recovery Stories 3
... expand coverage to 30 million uninsured Americans, seek to control ... agreement in principle on the landmark overhaul to the U.S. ... said Thursday. , The agreement in principle, which would cover ... and how many Americans could receive it, would then go ...
... Get Vaccinated ... -- National Influenza Awareness Week Jan. 10-16, 2010 , ... Bakersfield, Calif. (Vocus) January 14, 2010 -- U.S. HealthWorks Medical Group, ... that it is offering H1N1 vaccines for $15 per shot for both walk-ins -- no ...
... , Priority needs are food, water, shelter, medical ... With estimates that as many as three million people ... Tuesday, the American Red Cross is releasing an additional $9 million ... $10 million to support relief efforts in Haiti . , ...
... over 40% compound year -over-year growth rate since 1999 due to increased ... Medifast, Inc. (NYSE: MED ) has been the subject ... of outright, deliberate, and possibly illegal market manipulation. Beginning February 17, ... Fraud Discovery Institute (FDI) posted on the FDI website a "report" authored ...
... , FARMINGTON HILLS, Mich. , Jan. 14 ... a free webinar for long-term healthcare professionals entitled "Top 5 ... 1 pm EST . Register at: www.attendanceondemand.com/campaigns/webinar/index.html ... healthcare providers control cost of labor, the most significant expense ...
... to trauma center, study finds , THURSDAY, Jan. 14 (HealthDay ... of trauma patients, to avoid a broken neck or other ... likelihood that gunshot and stabbing victims will die if they ... researchers, who report their findings in the January issue of ...
Cached Medicine News:Health News:Lawmakers Getting Closer to Health Care Reform 2Health News:Lawmakers Getting Closer to Health Care Reform 3Health News:U.S. HealthWorks in Bakersfield is Offering $15 H1N1 Vaccinations for both Walk-Ins and On-Site 2Health News:American Red Cross Releases $10 Million to Help Haiti 2Health News:American Red Cross Releases $10 Million to Help Haiti 3Health News:Medifast, Inc. Complaints Against FDI Pending With the United States Department of Justice, the United States Securities and Exchange Commission, the Maryland Securities Commissioner 2Health News:Medifast, Inc. Complaints Against FDI Pending With the United States Department of Justice, the United States Securities and Exchange Commission, the Maryland Securities Commissioner 3Health News:Medifast, Inc. Complaints Against FDI Pending With the United States Department of Justice, the United States Securities and Exchange Commission, the Maryland Securities Commissioner 4Health News:Medifast, Inc. Complaints Against FDI Pending With the United States Department of Justice, the United States Securities and Exchange Commission, the Maryland Securities Commissioner 5Health News:Free Webinar 'Top 5 Tools to Control Labor Costs' for Long-Term Healthcare Professionals 1:00 pm EST January 26, 2010 2Health News:Stabilizing Spine May Be Waste of Time in Gun, Knife Victims 2
... Now there is a more efficient ... first fully portable battery operated patient ... and surgical teams with a compact ... throughout the entire surgical process. Its ...
... CSZ safely provides effective air warming therapy ... patented design of our WarmAir® FilteredFlo® blankets, ... which supplies gently moving, clean air that ... contaminants to your patient or staff. All ...
Since 1964, in its plants of Sesto Fiorentino, Sbisà produces a wide and qualified range of instruments for ophthalmology and optometry....
Inquire...
Medicine Products: