Hope for 14 Million Rosacea Sufferers: Pyratine-XR(TM) Study to be Presented at South Beach...(ilable treatments for rosacea primarily ...),Health

Date:2/12/2009

ilable treatments for rosacea, primarily oral and topical antibiotics, which involve long-term tolerability and other health concerns. Pyratine-XR(TM) produced a progressive decrease in the symptoms associated with rosacea including redness and lesions. All subject self-assessments showed good tolerability and cosmetic acceptability.

After 48 weeks, there was overall clinical improvement in 80% of subjects, including reduction of erythema and papules. The investigators saw continual, statistically significant mean improvement with Pyratine-XR(TM) treatment, including a 90% improvement in lesions, 45% improvement in erythema and a 28% improvement in telangiectasia. The product was well tolerated, and in an earlier assessment of 24 patients, there was a 41% mean improvement in skin dryness as early as week four, with results continuing to improve over the 48- week period. Pyratine-XR(TM) produced a significant improvement in skin barrier function at weeks 4 through 48 as measured by a decrease in water loss from the skin.

"We are incredibly pleased with the results reported in this rosacea- specific study, with continual improvement in lesions, redness and spider veins. Unlike current therapies, Pyratine-XR(TM) was well tolerated by all patients, and offers hope to a myriad of individuals suffering from facial redness, acne lesions and spider veins, such as those afflicted with eczema, atopic dermatitis and rosacea. We are pleased that the study results are being presented by Dr. Nestor at this prestigious meeting," said Frank J. Massino, Chairman and CEO of Senetek PLC. "The clinical trials are extremely promising, and we anticipate a tremendous physician and patient response to Pyratine- XR(TM), which will officially launch at the American Academy of Dermatology's 67th Annual Meeting in San Francisco, March 6-10, 2009."

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