Navigation Links
Hope for 14 Million Rosacea Sufferers: Pyratine-XR(TM) Study to be Presented at South Beach Symposium

NAPA, Calif., Feb. 12 /PRNewswire-FirstCall/ -- Senetek PLC (OTC Bulletin Board: SNKTY), a life sciences company engaged in the development of technologies that target the science of healthy aging, announced today that positive study results from a clinical trial of Pyratine-XR(TM) in patients with rosacea will be presented February 13, 2009, at the 7th Annual South Beach Clinical Dermatology Symposium in Miami, Florida.

Dr. Mark Nestor, the Symposium chair, will be presenting "Cytokinins: Cutaneous Aging and Rosacea" at 4:45 PM.

Based on positive results demonstrated in previous studies of Pyratine-6(TM) (0.1% furfuryl tetrahydropyranyladenine) for the remediation of photodamaged skin and erythema, with resulting reduction in facial redness and fine wrinkles in as early as two weeks, Senetek initiated a clinical trial for assessing the effects of Pyratine-XR(TM) (0.125% furfuryl tetrahydropyranyladenine) in improving the clinical signs and symptoms of rosacea.

According to the National Rosacea Society, more than 14 million Americans have rosacea, yet only a small fraction are being treated. The chronic skin disease can affect adults and children of any skin type. While the cause is unknown and there is no cure, scientific advancements are now offering rosacea sufferers hope and a way to control the signs and symptoms of this potentially life-disruptive disorder.

Eighteen subjects with mild-to-moderate rosacea participated in a 48-week study at the University of California, Irvine, and were evaluated through physician assessments of inflammatory lesion count (papules and pustules), severity of erythema (redness) and telangiectasia (spider veins) and overall clinical improvement, as well as through patient assessments of signs and symptoms of rosacea and skin tolerance.

Data suggests that Pyratine-XR(TM) may offer important advantages over currently available treatments for rosacea, primarily oral and topical antibiotics, which involve long-term tolerability and other health concerns. Pyratine-XR(TM) produced a progressive decrease in the symptoms associated with rosacea including redness and lesions. All subject self-assessments showed good tolerability and cosmetic acceptability.

After 48 weeks, there was overall clinical improvement in 80% of subjects, including reduction of erythema and papules. The investigators saw continual, statistically significant mean improvement with Pyratine-XR(TM) treatment, including a 90% improvement in lesions, 45% improvement in erythema and a 28% improvement in telangiectasia. The product was well tolerated, and in an earlier assessment of 24 patients, there was a 41% mean improvement in skin dryness as early as week four, with results continuing to improve over the 48- week period. Pyratine-XR(TM) produced a significant improvement in skin barrier function at weeks 4 through 48 as measured by a decrease in water loss from the skin.

"We are incredibly pleased with the results reported in this rosacea- specific study, with continual improvement in lesions, redness and spider veins. Unlike current therapies, Pyratine-XR(TM) was well tolerated by all patients, and offers hope to a myriad of individuals suffering from facial redness, acne lesions and spider veins, such as those afflicted with eczema, atopic dermatitis and rosacea. We are pleased that the study results are being presented by Dr. Nestor at this prestigious meeting," said Frank J. Massino, Chairman and CEO of Senetek PLC. "The clinical trials are extremely promising, and we anticipate a tremendous physician and patient response to Pyratine- XR(TM), which will officially launch at the American Academy of Dermatology's 67th Annual Meeting in San Francisco, March 6-10, 2009."

About Senetek, PLC

Senetek PLC (OTC Bulletin Board: SNKTY) is a life sciences company engaged in the development of breakthrough technologies that target the science of healthy aging. The company's extensive research collaborations have resulted in a strong pipeline of patented compounds and products with broad therapeutic applications and a leading presence in dermatology. Senetek collaborates with established specialty pharmaceutical companies in the final development and marketing of its proprietary products, most recently resulting in the development of kinetin, the best-selling anti-aging product sold in the North American physician market. For more information, visit the company's website at

About Dr. Mark S. Nestor

Mark S. Nestor, M.D., Ph.D. is a board-certified dermatologist and dermatologic surgeon, and director of the Center for Cosmetic Enhancement in Aventura, Florida. Dr. Mark Nestor currently serves as President of the American Society for Photodynamic Therapy, and as a Volunteer Associate Professor of the University of Miami, Miller School of Medicine. He is the immediate Past President of the International Society of Cosmetic and Laser Surgeons.

Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. Vermillion Presents Critical Data From Its OVA1 Clinical Trial
2. SynergEyes, Inc. Raises $13.3 Million in Series C Financing
3. DNA Therapeutics Closes 2.2 Million EUR Series A Financing Round
4. Omeros Receives $3.1 Million Milestone Payment from The Stanley Medical Research Institute for Schizophrenia Program
5. Phico Therapeutics Receives GBP1 Million Award From the Wellcome Trust to Take Anti-MRSA Nasal Product Through Early Clinical Trials
6. Cardio3 BioSciences Raises EUR13.7 Million in Series B Fundraising and Grant Funding
7. Michael J. Fox Foundation Awards $2.9 Million for Two New Parkinsons Disease Clinical Trials
8. Michael J. Fox Foundation Awards $2.7 Million to Four Industry Teams for Pre-Clinical Parkinsons Disease Research
9. Micromet Expands Committed Equity Financing Facility to $75 Million
10. German Innovation for HIV/AIDS Diagnostics has Been Used 2.5 Million Times in 2008
11. Radius Raises Additional $15 Million, Increasing Second Private Equity Financing Round to $82.5 Million
Post Your Comments:
(Date:11/25/2015)...  The total global healthcare industry is expected to grow ... Latin America has the highest projected growth at ... Japan ), is second with growth projected at 11.5%. ... healthcare expenditure. In 2013-2014, total government funded healthcare was nearly ... to 41.2% in 2013-2014. In real terms, out of pocket ...
(Date:11/25/2015)... Nov. 25, 2015  The American Academy of ... (ACOG), and the March of Dimes cheered today,s ... Our Infants Act of 2015 (S.799), which ... newborns born exposed to drugs, such as opioids, ... introduction, all three organizations have worked together leading ...
(Date:11/25/2015)... Nov. 25, 2015 AAIPharma Services Corp./Cambridge ... of at least $15.8  Million to expand its ... NC . The expansion will provide additional ... the growing demands of the pharmaceutical and biotechnology ... expansion will provide up to 40,000 square feet ...
Breaking Medicine Technology:
(Date:11/27/2015)... ... November 27, 2015 , ... A team of Swiss doctors has ... it. Surviving Mesothelioma has just posted the findings on the website. Click here ... the cases of 136 mesothelioma patients who were treated with chemotherapy followed by EPP ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... Lizzie’s Lice ... The company is offering customers 10% off of their purchase of lice treatment product. ... at full price. According to a company spokesperson. “Finding lice is a sure way ...
(Date:11/27/2015)... ... November 27, 2015 , ... MPWH, the No.1 Herpes-only dating community in the world, ... Table 1-1 ). More than 3.7 billion people under the age of 50 – ... according to WHO's first global estimates of HSV-1 infection . , "The data shocks ...
(Date:11/27/2015)... ... ... A simply groundbreaking television series, "Voices in America", which is hosted by ... of issues that are presently affecting Americans. Dedicated to providing the world with a ... the subjects consumers focus on, one episode at a time. , In the ...
(Date:11/27/2015)... ... November 27, 2015 , ... CBD College is proud to announce ... (CAAHEP) awarded accreditation to its Diagnostic Medical Sonography program. CBD College is honored to ... of twelve colleges and universities in the state of California make the cut. CBD ...
Breaking Medicine News(10 mins):