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HistoRx Earns Two Additional Patents on Standardization of Results from Digital Pathology Instruments
Date:10/6/2011

BRANFORD, Conn., Oct. 6, 2011 /PRNewswire/ -- HistoRx, the leader in quantitative immunohistochemistry, advances its proprietary position in digital pathology through the recent issuance of US patents covering key features necessary for achievement of reproducible, standardized image analysis results.  The U.S. Patent and Trademark Office has granted two new patents protecting the company's methods for standardization of digital microscopy instruments, methods required to generate high-quality reproducible clinical diagnostic data that precisely relates to biomarker concentrations in tissue sections.

For patient tissue specimens stained for a biomarker such as HER2, HistoRx believes that physicians and patients expect the same quantitative result regardless of the digital microscopy instrument used.  To achieve this, HistoRx evaluated sources of variability in digital scanning microscopy instrumentation that affect results.  One source of variability is the light source; a second is the path traveled by the light through each instrument.  By correcting for each of these, HistoRx achieved exceptionally high levels of reproducibility for an assay previously thought to be incapable of true standardization: with AQUA® technology, the same slide of breast cancer specimens stained for HER2 analyzed across five instruments standardized by this method attained a coefficient of variance of less than 5% (where typical variances are ~20%).

"These patents reinforce the value of HistoRx's unique approach to achieving objectivity and reproducibility in anatomic pathology," said Mark Gustavson, Ph.D., Director of Operations at HistoRx and one of the inventors.  "You cannot have clinical accuracy without analytical precision."

US Patent 7,978,258, issued to HistoRx on July 12, 2011, is entitled "Automatic Exposure Time Selection for Imaging Tissue" and pertains to methods for determining appropriate exposure time for acquiring d
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SOURCE HistoRx, Inc.
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