Navigation Links
High Blood Pressure Medicines Show Promise For Treating Heart Disease

ROCKVILLE, Md., Oct. 19 /PRNewswire-USNewswire/ -- Two medications commonly used to treat high blood pressure appear to be effective in treating a common type of heart disease known as stable ischemic heart disease, according to a new comparative effectiveness review funded by HHS' Agency for Healthcare Research and Quality. A version of the analysis was posted in the October 20 online version of the Annals of Internal Medicine.

Treatment featuring the two medications -- inhibitors of angiotensin-converting enzyme, or ACE inhibitors, and angiotensin receptor blockers, or ARBs -- can lead to a reduction in death, risk of heart attack, risk of stroke and fewer hospitalizations for heart failure for patients suffering from stable ischemic heart disease, researchers found. However, the drugs have risks of their own. Risks associated with ACE inhibitors include a persistent cough, sudden fainting, too much potassium in the blood, and dangerously low blood pressure (hypotension). Risks associated with ARBs include too much potassium in the blood and low blood pressure.

"Stable ischemic heart disease is a major cause of death in the United States, so these findings are very encouraging," said AHRQ Director Carolyn M. Clancy, M.D. "This comparative effectiveness report will be a useful tool for patients to help them work with their clinicians to make choices on treatment."

Stable ischemic heart disease occurs when the flow of oxygen-rich blood to the heart is reduced because of narrowed or blocked arteries. Symptoms of stable ischemic heart disease include decreased tolerance of exercise and severe chest pain on exertion (known as angina), which afflicts about 9 million U.S. adults. Long-term risks of stable ischemic heart disease include heart failure and heart attack. Overall, heart disease is among the nation's most common and deadly illnesses, afflicting nearly 80 million Americans and killing nearly 2,400 every day.

Standard treatment of stable ischemic heart disease consists of a modification of diet, exercise and medications including aspirin, anti-cholesterol drugs, nitroglycerin and beta blockers. These can keep the disease from worsening. However, while standard treatment usually alleviates chest pain, it is not universally successful in reducing risk of heart failure or heart attack.

For patients with advanced stable ischemic heart disease, treatment can include heart surgery (coronary artery bypass graft, in which surgeons use a blood vessel harvested from the chest, leg or arm to reroute blood flow around narrowed heart arteries) or angioplasty (a procedure in which a catheter is used to inflate a balloon inside the plaque-narrowed artery and a mesh tube called a stent is usually inserted to keep the artery open).

ACE inhibitors and ARBs, which are commonly prescribed to combat high blood pressure, also are used for treatment of a heart attack and chronic heart failure. Captopril (sold as Capoten), the first ACE inhibitor to be taken orally, has been commonly available in the United States since the early 1980s. ARBs, first approved for use in the United States in the mid-1990s, often are prescribed when a patient has adverse effects to ACE inhibitors, but ACE inhibitors are used more commonly.

The AHRQ report found that patients with stable ischemic heart disease who take an ACE inhibitor in addition to standard treatment can reduce the likelihood of several negative outcomes, including death from heart attack or heart failure, non-fatal heart attacks, hospitalization for heart failure, and revascularization (surgeries that reroute blood to the heart). Patients who take an ARB in addition to standard medications can reduce their risk of death from a heart-related cause, heart attack or stroke.

While some patients and clinicians pursue a course of treatment using both ACE inhibitors and ARBs, the report found that combined treatment does not show any benefit over an ACE inhibitor alone and that risks include fainting, diarrhea, low blood pressure and kidney problems.

The report found that existing studies provide few data on the medications' benefits or harms in specific populations such as people of different genders, ethnicity, diabetic status or those who have or don't have high blood pressure.

AHRQ's new report, Comparative Effectiveness of Angiotensin-Converting Enzyme Inhibitors or Angiotensin II Receptor Blockers Added to Standard Medical Therapy for Treating Stable Ischemic Heart Disease, is the newest research review from the Agency's Effective Health Care Program. That program, authorized by the Medicare Prescription Drug, Improvement and Modernization Act, represents an important federal effort to compare alternative treatments for health conditions and make the findings public. The program is intended to help patients, doctors, nurses, pharmacists and others choose the most effective treatments. The new report's findings will soon be available in plain-language summary guides for patients, clinicians and policymakers. Summary guides on numerous clinical topics, as well as other information and background on the Effective Health Care Program, can be found at

SOURCE Agency for Healthcare Research & Quality

SOURCE Agency for Healthcare Research & Quality
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. PNH Patients Treated with Soliris(TM) Experienced Dramatic Reduction in Blood Clots During Clinical Trials
2. ImmuneRegen BioSciences, Inc. Demonstrates Radilex(TM) Increases Disease-Fighting White Blood Cells
3. Cleveland Clinic Researchers Identify Mechanism Behind Platelet Function and Potentially Fatal Blood Clot Formation
4. Largest Study to Date Shows Significant Reductions in Risks of Blood Clots and Reintervention With CYPHER(R) Sirolimus-eluting Coronary Stent Compared to Taxus Stent
5. Nebivolol Lowers Blood Pressure in Mild-to-Moderate Hypertensive Patients as Demonstrated in a Study Published in the Journal of Clinical Hypertension
6. American Heart Association Comment Saving Lives in Type 2 Diabetics: Could It Be as Easy as Lowering Blood Pressure?
7. BioMosaics Glypican-3 Blood & Tissue Tests Receive CE Marking in Europe
8. Uncontrolled Blood Pressure Highest Among Hispanics, Prompting New Hypertension Project in Miami
9. AspenBio Pharma Reports Strong Results with Appendicitis Triage Blood Test from Large Multiple Hospital Study
10. Microlifes Home Blood Pressure Monitors Proven Accurate Even for Critical Patients
11. WaveSense Blood Glucose Meter One of Few Brands to Pass Rigorous TNO Tests
Post Your Comments:
(Date:6/23/2016)...  MedSource announced today that it has selected ... of choice.  This latest decision demonstrates MedSource,s commitment ... clients by offering a state-of-the-art electronic data capture ... as the EDC platform of choice in exchange ... has long been a preferred EDC platform by ...
(Date:6/23/2016)... June 23, 2016 Research and ... Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), ... Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is projected ... CAGR of 6.1% in the forecast period 2016 to ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... Forecast to 2022" report to their offering. ... date financial data derived from varied research sources to present ... impact on the market during the next five years, including ... sub markets, regional and country level analysis. The report provides ...
Breaking Medicine Technology:
(Date:6/25/2016)... Beach, CA (PRWEB) , ... June 25, 2016 , ... ... UCLA with Magna Cum Laude and his M.D from the David Geffen School of ... Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at the ...
(Date:6/24/2016)... ... 2016 , ... A recent article published June 14 on E ... goes on to state that individuals are now more comfortable seeking to undergo not ... as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Sessions in Dallas that it will receive two significant new grants to support ... as PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists ...
(Date:6/24/2016)... ... ... makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum ... by 2020 and then adjusting it yearly to increase at the same rate as the ... wage floor does not erode again, and make future increases more predictable. , The company ...
(Date:6/24/2016)... Vegas, Nevada (PRWEB) , ... June 24, 2016 ... ... Las Vegas client, The Grove Investment Group (TGIG), has initiated cultivation and processing ... Grove, in Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of ...
Breaking Medicine News(10 mins):