Navigation Links
High Blood Pressure May Heighten Effects of Alzheimer's Disease
Date:11/28/2007

CHICAGO, Nov. 28 /PRNewswire/ -- Having hypertension, or high blood pressure, reduces blood flow in the brains of adults with Alzheimer's disease, according to a new study presented today at the annual meeting of the Radiological Society of North America (RSNA).

"While hypertension is not a cause of Alzheimer's disease, our study shows that it is another hit on the brain that increases its vulnerability to the effects of the disease," said study co-author Cyrus Raji, scientist and M.D. and Ph.D. candidate at the University of Pittsburgh where the study was conducted.

Hypertension is a condition in which the blood circulates through the arteries with too much force. According to the National Heart, Lung and Blood Institute, approximately 50 million Americans have hypertension. People with hypertension are at elevated risk for heart attack, stroke and aneurysm. Recently, there has been mounting evidence tying cardiovascular health to brain health.

"This study demonstrates that good vascular health is also good for the brain," said co-author Oscar Lopez, M.D., professor of neurology and psychiatry at the University of Pittsburgh. "Even in people with Alzheimer's disease, it is important to detect and aggressively treat hypertension and also to focus on disease prevention."

For the study, the researchers used arterial spin-labeled magnetic resonance imaging (MRI), which can measure blood flow in the brain, to image 68 older adults. Arterial spin-labeled MRI is a novel, noninvasive technique that requires no external contrast agent.

The patient group included 48 normal individuals, including 38 with hypertension and 10 without; 20 Alzheimer's patients, including 10 with hypertension and 10 without; and 20 adults with mild cognitive impairment, 10 with hypertension and 10 without. Mild cognitive impairment, which affects brain functions such as language, attention and reasoning, is a transition stage between normal aging deficits in the brain and greater levels of dementia.

The MRI results showed that in all patient groups blood flow in the brain was substantially decreased in patients with hypertension compared to those without. Cerebral blood flow was lowest among the Alzheimer's patients with hypertension, but the normal group with hypertension showed significantly lower cerebral blood flow than the normal group without hypertension.

"These results suggest that by changing blood flow to the brain, hypertension -- treated or untreated -- may contribute to the pathology of Alzheimer's," Raji said.

Co-authors are C. Lee, M.D., W. Dai, Ph.D., J.Becker, Ph.D., L. Kuller, M.D., H. Gach, Ph.D., et al.

AT A GLANCE

-- Hypertension reduces cerebral blood flow in people with Alzheimer's

disease.

-- Arterial spin-labeled MRI is a novel, noninvasive imaging technique

that can measure cerebral blood flow.

-- Approximately 50 million Americans have hypertension.

Note: Copies of RSNA 2007 news releases and electronic images will be available online at RSNA.org/press07 beginning Monday, Nov. 26.

RSNA is an association of more than 41,000 radiologists, radiation oncologists, medical physicists and related scientists committed to excellence in patient care through education and research. The Society is based in Oak Brook, Ill. (RSNA.org)

Editor's note: The data in these releases may differ from those in the printed abstract and those actually presented at the meeting, as researchers continue to update their data right up until the meeting. To ensure you are using the most up-to-date information, please call the RSNA Newsroom at 1-312-949-3233.


'/>"/>
SOURCE Radiological Society of North America
Copyright©2007 PR Newswire.
All rights reserved

Related medicine technology :

1. PNH Patients Treated with Soliris(TM) Experienced Dramatic Reduction in Blood Clots During Clinical Trials
2. ImmuneRegen BioSciences, Inc. Demonstrates Radilex(TM) Increases Disease-Fighting White Blood Cells
3. Cleveland Clinic Researchers Identify Mechanism Behind Platelet Function and Potentially Fatal Blood Clot Formation
4. Largest Study to Date Shows Significant Reductions in Risks of Blood Clots and Reintervention With CYPHER(R) Sirolimus-eluting Coronary Stent Compared to Taxus Stent
5. Nebivolol Lowers Blood Pressure in Mild-to-Moderate Hypertensive Patients as Demonstrated in a Study Published in the Journal of Clinical Hypertension
6. American Heart Association Comment Saving Lives in Type 2 Diabetics: Could It Be as Easy as Lowering Blood Pressure?
7. BioMosaics Glypican-3 Blood & Tissue Tests Receive CE Marking in Europe
8. Uncontrolled Blood Pressure Highest Among Hispanics, Prompting New Hypertension Project in Miami
9. AspenBio Pharma Reports Strong Results with Appendicitis Triage Blood Test from Large Multiple Hospital Study
10. Microlifes Home Blood Pressure Monitors Proven Accurate Even for Critical Patients
11. WaveSense Blood Glucose Meter One of Few Brands to Pass Rigorous TNO Tests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2016)... 27 Avril 2016   ... de +5% sur le trimestre, soutenu par une ... Croissance de +16% des ventes aux ... Mauna Kea Technologies (Euronext : MKEA, FR0010609263 ; OTCQX : MKEAY), ... annonce aujourd,hui son chiffre d,affaires pour le premier ...
(Date:4/27/2016)... , April 27, 2016 Transparency ... "Skincare Devices Market - Global Industry Analysis, Size, Share, ... the report, the global skincare devices market was valued ... to expand at a CAGR of 10.1% from 2015 ... Browse the full Skincare Devices Market (Treatment Device ...
(Date:4/27/2016)... Kan. , April 27, 2016  Bayer ... , a senior from the University of Florida ... of the Bayer Excellence in Communication Award (BECA). ... schools, which were awarded a total of $70,000 ... the last four years, Bayer has provided a ...
Breaking Medicine Technology:
(Date:4/30/2016)... CA (PRWEB) , ... April 30, 2016 , ... “Aging well is a challenge for all of us, but there ... NCMA’s Dr. Parul T. Kohli . “Research is showing more and more that there are ... of disease and disability as we age.” Top priorities Dr. Kohli’s recommends for her patients include;, ...
(Date:4/29/2016)... ... 2016 , ... Since launching its annual volunteer campaign on ... footwear industry, has broken all previous participation records in its first two weeks ... during the months of April and May, the 2016 Footwear Cares initiative is ...
(Date:4/29/2016)... ... April 29, 2016 , ... The American workforce ... stability, even security. Most importantly, employees are the single most important asset in ... workers so unhappy? , Just under half of American workers are emotionally checked ...
(Date:4/29/2016)... ... April 29, 2016 , ... A new study by a ... diaphragmatic hernia have better survival rates if surgery is performed early. Approximately one ... the diaphragm fails to form completely, letting abdominal organs into the chest cavity ...
(Date:4/29/2016)... , ... April 29, 2016 , ... ... Canadian Celiac Association (CCA), is pleased to announce the launch of the ... nutritional articles, recipes, and more. The purpose of the GFCP Scoop ...
Breaking Medicine News(10 mins):