Navigation Links
HemoShear Announces Advancement of Predictive Drug Safety Systems
Date:7/18/2013

CHARLOTTESVILLE, Va., July 18, 2013 /PRNewswire/ -- HemoShear, LLC, a leading developer of human-relevant systems for drug development and discovery, today announced an important milestone in the development of systems that predict safety of new drugs and chemicals. Published in the American Journal of Physiology – Cell Physiology, the manuscript entitled "Hemodynamic flow improves rat hepatocyte morphology, function and metabolic activity in vitro" reports HemoShear's success in applying the core principles of its technology to replicate liver biology on the laboratory bench.  Development of non-human species systems is an important step towards systems that use human cells to predict drug and chemical effects in humans. 

(Logo: http://photos.prnewswire.com/prnh/20120416/PH86899LOGO )

HemoShear's work is valuable to the pharmaceutical industry because drug-induced liver injury, which is often not detected in pre-clinical animal and cell-culture studies, remains the most frequent cause of drug-induced toxicity and toxicity-related failures in clinical trials.  By accurately replicating organ and disease biology in the laboratory, HemoShear's human-relevant systems will reduce the risk of costly failures in clinical trials and accelerate development of safe and effective drugs in humans. 

Ajit Dash, M.D., Ph.D., HemoShear's Senior Director of Liver Systems, explains the significance of HemoShear's achievement.  "In contrast to traditional methods that do not provide critical physiological cues to restore human cell biology, HemoShear's principles of combining primary cells and fluid circulation patterns restore the most important biological functions of hepatocytes, which are necessary for prediction of drug metabolism and safety," said Dr. Dash.

"Our work on the rat system has enabled significant progress in developing a human liver surrogate system, which is currently being validated with known drugs.  HemoShear has already validated a physiologically accurate vascular system and vascular disease conditions.  By gaining access to our liver and vascular systems and diseases, our pharmaceutical partners can save millions of dollars by avoiding drugs that are doomed to fail, while redirecting precious resources to drug candidates that are more likely to succeed in humans," said Brian Wamhoff, Ph.D., HemoShear's co-founder and Vice President of R&D.

HemoShear's publication may be found at the following address:   
http://www.ncbi.nlm.nih.gov/pubmed/23485712

Dash A, Simmers MB, Deering TG, Berry DJ, Feaver RE, Hastings NE, Pruett TL, Lecluyse EL, Blackman BR, Wamhoff BR. Hemodynamic Flow Improves Rat Hepatocyte Morphology, Function and Metabolic Activity in vitro. Am J Physiol Cell Physiol. 2013 Mar 13 [Epub ahead of print]

About HemoShear, LLC

By applying physiologically accurate hemodynamics and biological transport to primary cell cultures, HemoShear creates human-relevant systems that accurately replicate the biology of organ systems and diseases for applications throughout drug discovery and development. Working in strategic partnerships with pharmaceutical, biotechnology and medical device companies, HemoShear generates meaningful data to increase confidence in decision-making, reduce risk of costly failures and identify efficacious therapies. HemoShear's science leads to new medicines and improves human health.  

For information about HemoShear, please visit www.hemoshear.com.


'/>"/>
SOURCE HemoShear, LLC
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. HemoShear to Present Translational Findings from its Vascular and Liver Human Relevant Systems
2. HemoShear Relocates and Expands Operations to Historic Martha Jefferson Property in Charlottesville, Virginia
3. HemoShear Adds Industry Veterans Mehmood Khan and Fred Brown to Board of Managers
4. HemoShear Unveils In Vitro Steatosis System at Annual Meeting of the Association for the Study of Liver Diseases
5. HemoShear Publishes Key Review on Human-Relevant Organotypic Systems
6. Cardium Announces Reverse Stock Split
7. STAAR Surgical Announces Second Quarter 2013 Results Release Date And Conference Call And Webcast
8. RXi Pharmaceuticals Announces CEO Interview
9. Bureau Veritas Announces Sargam Laboratory Private Limited Name Change
10. Comco Plastics Inc. Announces Its Expansion & Separation From The NYTEF Group.
11. Hill-Rom Announces Preliminary Fiscal 2013 Third Quarter Results and Search for New CFO; Adjusted Earnings Per Share Expected to be in Line with Guidance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... -- Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in ... . ... ... ... Astellas is ...
(Date:6/23/2016)...  Guerbet announced today that it has been named ... . One of 12 suppliers to receive ... support of Premier members through exceptional local customer service ... to lower costs. ... outstanding customer service from Premier," says Massimo Carrara ...
(Date:6/23/2016)... -- Research and Markets has announced the ... (United States, China, Japan, Brazil, United Kingdom, Germany, France, ... Surgical Procedure Volumes: ... provides surgical procedure volume data in a geographic context. ... analysis of growth drivers and inhibitors, including world population ...
Breaking Medicine Technology:
(Date:6/27/2016)... ... 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to Best ... individuals in the United States and Canada wear eyeglasses. Once considered to be a ... and make a fashion statement. Even celebrities use glasses as a way of creating ...
(Date:6/26/2016)... ... ... Kasmer, a legally blind and certified personal trainer is helping to develop a weight loss ... plans to fix the two major problems leading the fitness industry today:, ... , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily ... of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures ... . Simply select a ProHand generator and drag it above media or text in ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Conventional wisdom ... of success. In terms of the latter, setting the bar too high can result ... more than just slow progress toward their goal. , Research from PsychTests.com ...
(Date:6/24/2016)... ... June 24, 2016 , ... The ... in Dallas that it will receive two significant new grants to support its ... PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists for ...
Breaking Medicine News(10 mins):