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HemaQuest Pharmaceuticals, Inc. Presents Promising Clinical Results at 52nd Annual Meeting of the American Society of Hematology (ASH)
Date:12/7/2010

ORLANDO, Fla., Dec. 7, 2010 /PRNewswire/ -- HemaQuest Pharmaceuticals, Inc. (HemaQuest), a biotechnology company focused on developing small molecule therapeutics to treat hemoglobin-associated diseases, presented encouraging results at the ASH meeting in Orlando, Florida from its first two clinical trials evaluating its lead product candidate, HQK-1001, an orally administered Small Chain Fatty Acid Derivative (SCFAD) in patients with sickle cell disease and beta thalassemia.

In the sickle cell disease clinical trial, a total of 24 patients were randomized and treated once daily at one of three dose levels (10, 20 or 30 mg/kg) of HQK-1001 or placebo for two six-week cycles of therapy with a two-week treatment break between cycles. HQK-1001 was well-tolerated with no significant drug-related adverse events. In addition, increases in fetal hemoglobin levels, the key pharmacodynamic marker, were documented in patients treated at all HQK-1001 dose levels but not in the placebo-treated patients. There was also a trend of increasing rises of fetal hemoglobin levels with increased dose up to the maximum tested dose level of 30 mg/kg. Analysis of additional pharmacodynamic markers in selected patients demonstrated induction of fetal globin as manifested by increases in fetal hemoglobin containing red blood cells (F-cells) and fetal globin mRNA in the HQK-1001 treated patients.

In the beta thalassemia clinical trial, a total of 21 patients with beta thalassemia intermedia, including Hb E thalassemia, were randomized and treated once daily with HQK-1001 at one of four dose levels (10, 20, 30 or 40 mg/kg) or placebo for eight weeks. HQK-1001 was well-tolerated with no significant drug-related adverse events. Rises in fetal hemoglobin levels were observed in HQK-1001-treated patients, with the most consistent and largest effects observed at the 20 mg/kg dose level.

HemaQuest President and CEO John Longenecker, PhD, said, "These clinical trials provide
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SOURCE HemaQuest Pharmaceuticals
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