Navigation Links
Hanmi and Kinex Announced Korean FDA Allowance of the KX01 IND Application
Date:11/6/2012

BUFFALO, N.Y. and SEOUL, South Korea, Nov. 6, 2012 /PRNewswire/ -- Kinex Pharmaceuticals and Hanmi Pharmaceutical announced today that the Korean FDA (KFDA) has accepted Hanmi's Investigational New Drug (IND) application for KX-01, Kinex's dual src/pretubulin inhibitor, in the oncologic setting. The data package included Kinex's preclinical and clinical data for KX-01, as well as Hanmi's preclinical gastric cancer data.

KX01 differentiates itself as an inhibitor that targets the kinase substrate pocket and therefore offers an excellent efficacy as well as safety profile. In addition, KX01 has potent inhibitory activity against pre-tubulin. KX01 has been shown to be very effective against a broad range of cancers in both in vitro experiments and in animal cancer models. Importantly, the compound has synergistic/additive activities with a number of first line chemotherapeutic agents. A completed Phase I study, in patients with end-stage cancer, showed a desirable safety profile and stable disease or clinical response in approximately 25% of the patients. Proof-of-concept studies are ongoing. The composition of matter of KX01 is covered by issued patents.

Dr. Gwan-Sun Lee, President and CEO of Hanmi said, "This is another important milestone in our successful partnership with Kinex. This also demonstrates our growing focus and commitment to oncology therapeutics."

"This is a major step forward," added Dr. Jeewoong Son, Senior VP and Head of Innovation R&D, at Hanmi. "The close collaboration between our scientific teams has helped define our initial development strategy. Kinex is a great partner and continues to show strong support. We will continue focus our efforts on unmet oncology needs together."

"Kinex is pleased to be working with such a committed partner," commented Dr. Lyn Dyster, SVP of Operations. "Hanmi's ability to work with their local regulatory bodies to advance the KX01 development program in Korea is a critical step in our overall development strategy."

Dr. Rudolf Kwan, CMO of Kinex stated, "The acceptance of Hanmi's IND by the Korean FDA is a crucial piece of our mutual development plans and will generate important clinical data for both parties soon. Kinex will also pursue additional development pathways to broaden KX-01's potential utility."

Kinex is also developing oral forms of Paclitaxel and Irintotecan, both are in clinical stages of development, through a licensing agreement with Hanmi Pharmaceuticals. Kinex is also developing KX02 for brain tumors with Xiangxue Pharmaceuticals based in Guangzhou, China.

About Kinex Pharmaceuticals, LLC

Kinex Pharmaceuticals, headquartered in Buffalo, New York, USA, is using its proprietary technologies Mimetica and Opal to discover and develop novel drugs for oncology and immune-modulatory diseases. More information of Kinex Pharmaceuticals can be found at www.kinexpharma.com or contact Mr. Patrick Gallagher, pgallagher@kinexpharma.com,  716-898-8626

Kinex Pharmaceuticals, LLC, Caution Regarding Forward-looking Information

Under the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995, Kinex Pharmaceuticals cautions investors that any forward-looking statements or projections made by Kinex Pharmaceuticals, including those made in this announcement, are subject to risks and uncertainties that may cause actual results to differ materially from those projected

About Hanmi Pharmaceutical, Co., Ltd

Established in 1973 in Korea, Hanmi Pharmaceuticals now is one of the top 5 pharmaceutical companies in terms of revenue, and the most R&D focused company with the highest R&D investment for several years. Hanmi has been successful for a few decades with high flexibility, continuously changing its market/development strategy from first generics to IMD & FDC (Incrementally Modified Drug and Fixed Dose Combination) to new drug development including innovative small molecules and biologics. During the period of significant changes, Hanmi made multiple strategic collaboration relationships with multinational companies and biotech companies.

For further information about Hanmi Pharmaceuticals, please refer to www.hanmipharm.com


'/>"/>
SOURCE Kinex Pharmaceuticals
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Xiangxue Pharmaceuticals to Acquire Rights for a Promising Drug Candidate from Kinex Pharmaceuticals for the Greater China Territory
2. Kinex Pharmaceuticals Receives Substantial Strategic Investment
3. Kinex Pharmaceuticals Appoints Mr. Patrick Gallagher Vice President of Business Development and Investor Relations
4. Gen-Probe Withdraws from Previously Announced Investor Presentations
5. Genesis Biopharma Announces Termination of Previously Announced Proposed Public Offering
6. LTCLINK-Tank Competition Announced To Introduce Your Emerging Product to the Aging Care Continuum
7. Delcath Announced Changes To Board Of Directors
8. Speakers Announced for the 2012 International Iridoid Research Symposium
9. Bausch + Lomb Announces Extension of Early Tender Date for Its Previously Announced Tender Offer for Its 9 7/8% Senior Notes due 2015 (CUSIP Nos. 071707AN3, U07190AA6 and 071707AP8)
10. Online Pharmacy Domain Policy Changes Announced by ICANN Registrar Internet.bs Corp.
11. Bausch + Lomb Announces Final Results for Its Previously Announced Tender Offer for Its 9 7/8% Senior Notes due 2015 (CUSIP Nos. 071707AN3, U07190AA6 and 071707AP8)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2017)... June 19, 2017  Hill-Rom Holdings, Inc. (NYSE: HRC), will ... webcast on Friday, July 28, 2017, beginning at 7:30 a.m. ... Only Dial-in information: To participate in the conference call, dial ... the call at least 10 minutes prior to the start ... Webcast: A simultaneous ...
(Date:6/14/2017)... -- The Bio Supply Management Alliance (BSMA) has announced ... and the Biomedical Manufacturing Network to advance the ... California by providing a platform for imparting ... development. The primary focus of this alliance is to ... as small and mid-sized biomedical companies. ...
(Date:6/10/2017)... K. Burchfield, DPM, is recognized by Continental Who,s Who as a ... Alabama . Dr. Burchfield serves as ... over 20 years of experience, as well as expertise in the ... "The podiatry professional ... to welcome you to his practice," the company,s website states. "We ...
Breaking Medicine Technology:
(Date:6/20/2017)... IN (PRWEB) , ... June 20, 2017 , ... ... benefits advisory organization, announces recipients of its annual “UBBIE” Awards (pronounced you-bee) for ... who have demonstrated significant achievements toward their involvement with UBA, the clients they ...
(Date:6/20/2017)... ... June 20, 2017 , ... ... services, has published a new eBook titled “ 5 Questions to Ask Before ... Research Analyst on the Genetic Test Evaluation (GTE) team, the book explores the ...
(Date:6/20/2017)... ... 2017 , ... EdChoice and the American Enterprise Institute each ... economic development in economically distressed urban areas. The first report presents a case ... the economic development of the city of Santa Ana, California. The second report ...
(Date:6/20/2017)... , ... June 20, 2017 , ... ... help content solutions for the enterprise, is proud to announce Touchpoints ... e-commerce, ticketing systems, company websites, and more to provide a seamless customer experience. ...
(Date:6/20/2017)... BC (PRWEB) , ... June 20, 2017 , ... As ... community on the link between stroke and gum disease. Those with bleeding gums in ... If left untreated, this condition can lead to heart disease, stroke and diabetes. Drs. ...
Breaking Medicine News(10 mins):