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Halozyme's rHuPH20 With Recombinant Human Insulin Demonstrates Glycemic Control Comparable to Lispro
Date:11/12/2010

SAN DIEGO, Nov. 12, 2010 /PRNewswire-FirstCall/ -- Halozyme Therapeutics, Inc. (Nasdaq: HALO) today announced Phase 2 results demonstrating that Insulin-PH20 (recombinant human insulin with rHuPH20) produced glycemic control comparable to lispro, a widely prescribed prandial (mealtime) insulin analog. The overall safety and adverse event profiles for the two agents were comparable and both treatments were well tolerated. Insulin-PH20 achieved the primary endpoint of non-inferiority for glycemic excursions relative to lispro alone in this study conducted in a take-home diabetes treatment setting. This study represents the first reported experience in a clinical trial where patients received Halozyme's recombinant human hyaluronidase enzyme, rHuPH20, three times daily for 12 weeks for a total of over 10,000 doses of enzyme with insulin. Halozyme presented these results today at the Diabetes Technology Society meeting in Bethesda, Md.

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"Halozyme has demonstrated that the combination of its PH20 enzyme with recombinant human insulin accelerates the pharmacokinetic profile to that of the currently marketed prandial analogs. The combination produces treatment effects and a safety profile comparable to the analog insulin lispro," stated Doug Muchmore, M.D., vice president of endocrinology clinical development. "The glycemic excursion results, occurrence of hypoglycemia, and reported adverse events were comparable for the two test t
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SOURCE Halozyme Therapeutics, Inc.
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