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Halozyme's Ultrafast Insulin Demonstrates Reduced Variability of Insulin Absorption for Type 1 Diabetes Patients Using Insulin Pumps
Date:6/24/2011

SAN DIEGO, June 24, 2011 /PRNewswire/ -- Halozyme Therapeutics, Inc. (Nasdaq: HALO) today announced final results from a study in type 1 diabetes patients who receive their insulin treatment with a pump demonstrating that Aspart-PH20, a formulation of Halozyme's rHuPH20 (recombinant human hyaluronidase) with the active ingredient in NovoLog®, reduces the variability of insulin absorption and reduces post-meal glycemic excursions compared to NovoLog alone. Halozyme is presenting these findings in a late-breaking poster titled: "Addition of Human Hyaluronidase to Rapid Analog Insulin Reduces the Absolute Variability of Early Insulin Absorption across Infusion Set Life" at the American Diabetes Association 71st Scientific Sessions on Sunday, June 26 in San Diego.  

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"These additional results from Halozyme's first pump study demonstrate that the faster pharmacokinetic and glucodynamic findings are significantly more consistent and less variable for the Aspart-PH20 combination than for NovoLog alone in the pump setting," stated Doug Muchmore, M.D., vice president of endocrinology clinical development at Halozyme. "More consistent and rapid insulin absorption over the life of the infusion set with the addition of rHuPH20 may help patients using insulin pumps achieve tighter glucose control, better manage their disease and obtain improved outcomes."

The double-blind crossover design Phase 1 clinical trial compared Aspart-PH20 to as
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SOURCE Halozyme Therapeutics, Inc.
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