Navigation Links
Halozyme Therapeutics Presents Pre-Clinical Studies of Systemic Delivery of Pegylated rHuPH20 Enyzme in Prostate Cancer Models at American Association for Cancer Research Conference
Date:4/15/2008

ry of findings is as follows:

-- Prostate carcinoma cells assembled large pericellular coats in vitro

that collapsed in the presence of the hyaluronidase enzyme, rHuPH20.

Similar pericellular matrices containing HA were also assembled in vivo

following inoculation of tumors around the bone in mice.

-- PEGrHuPH20 significantly reduced tumor IFP in a dose dependent fashion,

achieving more than 85% reduction in IFP following IV administration.

Peritumoral HA remained depleted over 3 days after a single dose of

enzyme.

-- Consistent with the histologic collapse of pericellular HA surrounding

the tumor cells, tumor water content significantly decreased over 3

days, consistent with changes detected in the tumor by MRI and IFP

monitoring.

-- Furthermore, a 3.5-fold selective increase in tumor vascular volume was

achieved within 8 hours post-dosing as a result of vascular

decompression of blood vessels within the tumor, which was confirmed by

histology and ultrasound.

"These findings represent significant advancements towards our goal of understanding the role of HA in the tumor microenvironment and mechanism of action of PEGrHuPH20" said Gregory Frost, PhD, Halozyme's Vice President and Chief Scientific Officer. "By selectively decompressing tumor vessels, we may significantly improve tumor exposure and responses to chemotherapy regimens. These findings have facilitated our efficacy studies in combination with selected chemotherapy agents, which will be presented later this year as part of our overall development strategy for this new compound."

About Halozyme Therapeutics, Inc.

Halozyme is a biopharmaceutical company developing and commercializing products targeting the extracellular matrix for the drug delivery, oncology and dermatology markets. The company's portfolio of products and product candidates is based
'/>"/>

SOURCE Halozyme Therapeutics, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Halozyme Therapeutics Announces Peer-Reviewed Publications of the INFUSE-LR Clinical Trial Results and Clinical Practice Experience With Hylenex
2. Halozyme Therapeutics Completes Enrollment in Chemophase Phase I/IIa Clinical Trial for Superficial Bladder Cancer
3. Nektar Therapeutics to Present Positive Data at Upcoming Medical and Scientific Meetings
4. Echo Therapeutics Announces Positive Results with the Prelude(TM) SkinPrep System, the Next-Generation Skin Permeation Medium for its Symphony(TM) Transdermal Continuous Glucose Monitoring System
5. Recent siRNA Research Publications Support Silence Therapeutics Combined Development Approach
6. European Regulatory Agency Accepts Cell Therapeutics, Inc.s Marketing Authorization Application for XYOTAX(TM) for Lung Cancer for Review
7. CV Therapeutics Anti-Ischemic Therapy Ranexa(R) Significantly Reduces Cardiac Chest Pain Symptoms and Recurrent Ischemia in MERLIN-TIMI 36 Patients With Angina
8. Michael J. Fox Foundation Commits up to $10 Million for Pre-Clinical Drug Development Under Therapeutics Development Initiative
9. Synvista Therapeutics Presents New Preclinical Data Demonstrating the Value of Haptoglobin Genotype Testing In Diabetes at ACC Scientific Sessions
10. Cell Therapeutics, Inc. (CTI) Announces Enrollment Complete in Phase III EXTEND (PIX301) Clinical Trial of Pixantrone in Patients With Second or Greater Relapse of Diffuse Large B Cell NHL
11. Dynamis Therapeutics, Inc. Discovers RAGE Inhibitor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... May 5, 2015  ANI Pharmaceuticals, Inc. ("ANI") (NASDAQ: ... three months ended March 31, 2015 and reaffirmed its ... for 2015. First Quarter 2015 Highlights Include: ... increase of 72% as compared to $10.9 million for ... adjusted non-GAAP EBITDA of $11.5 million, an increase of 170% ...
(Date:5/5/2015)... May 5, 2015 Tissue ... Group"), the regenerative medical devices company, announces that ... regional distribution contract for DermaPure® which is used ...      (Logo: http://photos.prnewswire.com/prnh/20150505/743321) , ... since Tissue Regenix received notice of Local Coverage ...
(Date:5/5/2015)... , May 5, 2015  Stryker Orthopaedics announced ... Ponte Vedra, FL.  Since becoming the ... Champions Tour" over one year ago, the company has ... Tour combined, with its onsite activation the Stryker Mobility ... on the importance of joint health. Proving to be ...
Breaking Medicine Technology:ANI Pharmaceuticals Reports First Quarter 2015 Financial Results 2ANI Pharmaceuticals Reports First Quarter 2015 Financial Results 3ANI Pharmaceuticals Reports First Quarter 2015 Financial Results 4ANI Pharmaceuticals Reports First Quarter 2015 Financial Results 5ANI Pharmaceuticals Reports First Quarter 2015 Financial Results 6ANI Pharmaceuticals Reports First Quarter 2015 Financial Results 7ANI Pharmaceuticals Reports First Quarter 2015 Financial Results 8ANI Pharmaceuticals Reports First Quarter 2015 Financial Results 9Tissue Regenix Group plc: US Regional Distribution Agreement Signed 2Stryker Returns to TPC Sawgrass for THE PLAYERS Championship Alongside Former Tournament Winners Fred Funk and Hal Sutton 2Stryker Returns to TPC Sawgrass for THE PLAYERS Championship Alongside Former Tournament Winners Fred Funk and Hal Sutton 3
... following is a statement of Matthew L. Myers, ... http://photos.prnewswire.com/prnh/20080918/CFTFKLOGO ) (Logo: http://www.newscom.com/cgi-bin/prnh/20080918/CFTFKLOGO ... and Drug Administration for taking appropriate enforcement action ... various violations of the Federal Food, Drug and ...
... Sept. 9 The U.S. Food and Drug ... Chloride (pralidoxime chloride), a drug used to treat ... agents). The drug is approved to be administered ... (Logo:   http://photos.prnewswire.com/prnh/20090824/FDALOGO ) ...
Cached Medicine Technology:FDA Takes Appropriate Action to Regulate Electronic Cigarettes and Protect Public Health 2FDA Approves Pediatric Use of Chemical Poisoning Treatment 2
(Date:5/5/2015)... Tulsa, Oklahoma (PRWEB) May 05, 2015 ... have the money for a fitness membership? Don’t know ... all of these obstacles in order to help members ... greatest life. Live Streaming Fitness, an educational, caused-based wellness ... that offers live streaming fitness classes led by certified ...
(Date:5/5/2015)... Specialty makeup brand Beauty For ... on a collection of summer-oriented cosmetics and personal-care ... the debut five-piece summer collection, Beauty For Real ... ; the retailer's fast-growing intimates, swim and lounge ... uses models of various sizes and doesn't digitally ...
(Date:5/5/2015)... 2015 HealthSlide, Inc ., ... solutions for hospitals nationwide, has announced the launch ... CIOs and CTOs can access the calculator on ... both initial and ongoing savings of switching to ... nation’s hospitals pay an average of $300,000 a ...
(Date:5/5/2015)... May 05, 2015 After conducting a ... solutions firm B. E. Smith, West Holt Medical ... as chief executive officer. A skilled healthcare executive with ... assume his new duties on June 1st. , “Brad ... well as a keen understanding and success in building ...
(Date:5/5/2015)... Atlantic Information Services, Inc. (AIS), ... Health Plans, and other industry-leading health care business ... newsletter, AIS’s Value-Based Care News. Written for health ... companies and their advisers, AIS’s Value-Based Care News ... payments, coordinated care, global payments and other innovative ...
Breaking Medicine News(10 mins):Health News:Live Streaming Fitness Creates Industry Shift by Bringing Fitness, Nutrition and Cooking Classes to Smart Devices 2Health News:Live Streaming Fitness Creates Industry Shift by Bringing Fitness, Nutrition and Cooking Classes to Smart Devices 3Health News:BLKBOXLabs Finds Real Beauty in Beauty For Real and American Eagle Outfitters’ Aerie-Branded Beauty Line 2Health News:BLKBOXLabs Finds Real Beauty in Beauty For Real and American Eagle Outfitters’ Aerie-Branded Beauty Line 3Health News:HealthSlide Launches ROI Cost Calculator 2Health News:West Holt Medical Services Hires New Chief Executive Officer 2Health News:West Holt Medical Services Hires New Chief Executive Officer 3Health News:New AIS Newsletter Features Expert Insights and Strategies on Value-Based Care Arrangements 2
... ... ... the tennis season now firmly underway, leading voucher codes site Savoo has ... shortest tennis skirts at Wimbledon this tournament., , ,Savoo.co.uk found that Maria Sharapova topped the ...
... ... decreasing labor costs in all 10 of its facilities in the Chicago area. OnShift enabled ... ... OnShift, ( www.OnShift.com ), developers of nurse scheduling and employee communication software, recently announced it ...
... ... discount. , ... can now declare their independence from tobacco cigarettes with a new e-cigarette system offered exclusively ... exciting new developments for smokers who want an alternative to inhaling a lit tobacco ...
... ... the database cover the full spectrum of medical needs including everything from allergic shots ... ... directory of doctors for all medical needs. Regardless of the medical condition potential ...
... Programme for Research and Training in Tropical Diseases (TDR) ... the African Network for Drugs and Diagnostics Innovation, which ... on the African continent. They discuss the ... approach to support health product research and development (R&D) ...
... DC -- Should we spend more money urging ... or should those dollars and effort be used for discovering ... published online June 29 in issue 14 of the ... Mandelblatt, MD, MPH, of the Lombardi Comprehensive Cancer Center at ...
Cached Medicine News:Health News:All Eyes on Hemlines, Not Henman, at Wimbledon This Year 2Health News:Lexington Health Care Chooses OnShift for Nurse Scheduling and Employee Communications in all Facilities 2Health News:Lexington Health Care Chooses OnShift for Nurse Scheduling and Employee Communications in all Facilities 3Health News:Electronic Cigarettes and the Declaration of Independence 2Health News:DrFinders Releases Searchable Online Directory of Doctors for All Medical Needs 2Health News:Researchers suggest new paradigm for breast cancer screening 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: