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Halozyme Therapeutics Presents Pre-Clinical Studies of Systemic Delivery of Pegylated rHuPH20 Enyzme in Prostate Cancer Models at American Association for Cancer Research Conference
Date:4/15/2008

ry of findings is as follows:

-- Prostate carcinoma cells assembled large pericellular coats in vitro

that collapsed in the presence of the hyaluronidase enzyme, rHuPH20.

Similar pericellular matrices containing HA were also assembled in vivo

following inoculation of tumors around the bone in mice.

-- PEGrHuPH20 significantly reduced tumor IFP in a dose dependent fashion,

achieving more than 85% reduction in IFP following IV administration.

Peritumoral HA remained depleted over 3 days after a single dose of

enzyme.

-- Consistent with the histologic collapse of pericellular HA surrounding

the tumor cells, tumor water content significantly decreased over 3

days, consistent with changes detected in the tumor by MRI and IFP

monitoring.

-- Furthermore, a 3.5-fold selective increase in tumor vascular volume was

achieved within 8 hours post-dosing as a result of vascular

decompression of blood vessels within the tumor, which was confirmed by

histology and ultrasound.

"These findings represent significant advancements towards our goal of understanding the role of HA in the tumor microenvironment and mechanism of action of PEGrHuPH20" said Gregory Frost, PhD, Halozyme's Vice President and Chief Scientific Officer. "By selectively decompressing tumor vessels, we may significantly improve tumor exposure and responses to chemotherapy regimens. These findings have facilitated our efficacy studies in combination with selected chemotherapy agents, which will be presented later this year as part of our overall development strategy for this new compound."

About Halozyme Therapeutics, Inc.

Halozyme is a biopharmaceutical company developing and commercializing products targeting the extracellular matrix for the drug delivery, oncology and dermatology markets. The company's portfolio of products and product candidates is based
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SOURCE Halozyme Therapeutics, Inc.
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