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Halozyme Therapeutics Announces Positive Findings With Pegylated Enzyme in Prostate Cancer Models
Date:7/22/2008

e span by 225% while docetaxel alone increased life span by 59% relative to control. Furthermore, the survival benefit produced by the combination treatment was significantly better than docetaxel alone (p=0.003).

Xenograft Du145luc results

-- Tumor volume growth unaffected by combination treatment, as expected. Human Du145luc prostate tumor cells do not produce hyaluronan, and no change in interstitial fluid pressure was observed following PEGPH20 treatment. Therefore, treatment with an HA-reducing treatment regimen would not be expected to provide a therapeutic benefit. Results demonstrated no meaningful difference in tumor volume between the docetaxel alone and PEGPH20 plus docetaxel treatment groups. In addition, unlike the HA-producing PC3 tumors, tumor growth curves in the control and the PEGPH20 groups were virtually superimposable. These findings support the proposed mechanism of action that only HA-producing tumors would be most susceptible to PEGPH20.

PC3-M-luc bone metastases results

-- Survival benefit demonstrated. Two different combination dosage regimens of PEGPH20 plus docetaxel demonstrated improved survival compared to the control group. For this model, tumor cells are injected directly into the left ventricle and migrate to bone tissue.

Hyaluronan is a dominant constituent of the extracellular matrix in subsets of many solid tumor types, including prostate, breast, ovarian, pancreatic, and gastric, where it may increase the resistance to chemotherapeutic agents. Previous studies presented by Halozyme (Thompson et al. Proceedings AACR Annual Meeting, Volume 49, April 2008) demonstrated significant reductions of HA around the tumor, IFP, and tumor water content after intravenous administration of PEGPH20. Elevated tumor IFP is believed to limit the response to cytotoxic treatment regimens in many solid tumors. Removal of peritumoral HA and the lowering of IFP may potentially lead to improved responses to chemothera
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SOURCE Halozyme Therapeutics, Inc.
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